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Vitamin B deficiency may cause vascular cognitive impairment

A deficiency of B-vitamins may cause vascular cognitive impairment, according to a new study. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University used an experimental model to examine the metabolic, cognitive, and microvascular effects of dietary B-vitamin deficiency.

2 Sep 2008

Novel imaging reagents and technology that non-invasively locates, quantifies specific cells in the body

Magnetic resonance imaging (MRI) isn't just for capturing detailed images of the body's anatomy. Thanks to novel imaging reagents and technology developed by Carnegie Mellon University scientist Eric Ahrens, MRI can be used to visualize - with "exquisite" specificity - cell populations of interest in the living body. The ability to non-invasively locate and track cells, such as immune cells, will greatly aid the study and treatment of cancer, inflammation, and autoimmune diseases, as well as provide a tool for advancing clinical translation of the emerging field of cellular regenerative medicine, by tracking stem cells for example.

21 Aug 2008

Bone marrow stem cells used to protect gastrointestinal tissue from autoimmune attack

Massachusetts General Hospital (MGH) investigators have found that infusions of a particular bone marrow stem cell appeared to protect gastrointestinal tissue from autoimmune attack in a mouse model.

20 Aug 2008

NanoViricides reports HIVCide-I significantly superior to current anti-HIV three drug cocktail standard

NanoViricides, Inc. said that additional biological tests and data analysis have shown that animals treated with its lead anti-HIV drug candidate, HIVCide-I, demonstrated a substantially greater reduction in viral load -- number of infectious virus particles per milliliter of blood -- when compared to the animals given the anti-HIV "combo cocktail" in a preliminary animal study. An important objective of anti-HIV treatment is to minimize the viral load.

11 Aug 2008

Scientists stop age-related decline in an entire organ

As people age, their cells become less efficient at getting rid of damaged protein - resulting in a buildup of toxic material that is especially pronounced in Alzheimer's, Parkinson's disease, and other neurodegenerative disorders.

10 Aug 2008

How short RNAs influence many proteins

During the last decade, microRNAs have emerged somewhat surprisingly as key players in the way genes are regulated. These short snippets of RNA do their work by interacting with messenger RNAs, which act as blueprints for protein creation.

6 Aug 2008

Cannabinoid cell surface receptor plays a tumor-suppressing role in human colorectal cancer

CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. It now may serve as a new path for cancer prevention or treatment.

3 Aug 2008

Eroded telomeres are behind dyskeratosis congentia aging syndrome

Each time a cell divides, the protective caps at the ends of chromosomes shorten - and when these caps are gone, so are we. Now, by using an unconventional strategy to shorten telomeres in mice, researchers at Rockefeller University have not only created the first faithful mouse model for studying a rare yet fatal premature aging syndrome, but they have revealed the molecular defect behind the disease.

30 Jul 2008

Laboratory and mouse studies show targeted drug blocks the growth of breast cancer cells that spread to the brain

Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cells can inhibit the growth of breast cancer cells that migrate to the brain.

29 Jul 2008

Research sheds light on the molecular basis of SIDS

Sudden Infant Death Syndrome (SIDS) is a condition that unexpectedly and unexplainably takes the lives of seemingly healthy babies aged between a month and a year.

3 Jul 2008

Zinc finger technology brings personalized HIV therapy a step closer

Researchers at the University of Pennsylvania School of Medicine and collaborators are using minute, naturally occurring proteins called zinc fingers to engineer T cells to one day treat AIDS in humans.

30 Jun 2008

Transplants of mononuclear human umbilical cord blood may help Lou Gehrig's patients

A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood (MNChUCB) cells may help patients suffering from Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.

24 Jun 2008

New discovery could lead to new treatments for Alzheimer's

Rutgers researcher Karl Herrup and colleagues at Case Western Reserve University have discovered that a protein that suppresses cell division in brain cells effectively "puts the brakes" on the dementia that comes with Alzheimer's disease (AD). When the brakes fail, dementia results.

24 Jun 2008

Discovery of an important factor in the development of B-cell lymphomas

Researchers at National Jewish Medical and Research Center have discovered an important factor in the development of B-cell lymphomas, one of the fastest growing forms of cancer. The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas.

24 Jun 2008

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature Medicine publishes the findings in its online June 22 edition.

23 Jun 2008

Polyphenolics derived from red grapes may help treat Alzheimer's disease

Mount Sinai researchers have discovered that polyphenolics derived from red grape seeds may be useful agents to prevent or treat Alzheimer's disease (AD).

17 Jun 2008

Peregrine Pharmaceuticals awarded two new U.S. patents for targeted anti-aminophospholipid agents

Peregrine Pharmaceuticals, Inc. today reported the issuance of two U.S. patents that significantly broaden the company's intellectual property leadership in the field of targeted anti-aminophospholipid agents.

16 Jun 2008

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

One of the most vexing problems in treating cancer is the propensity of tumors to develop resistance to a wide range of anticancer drugs. Over 70 percent of ovarian cancer patients, for example, have drug-resistant tumors at the time of their initial diagnosis, and virtually all patients who relapse have drug-resistant tumors.

15 Jun 2008

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Researchers at Mayo Clinic, with their national and international collaborators, have discovered how a class of agents now in testing to treat Alzheimer's disease work, and say they may open up an avenue of drug discovery for this disease and others.

11 Jun 2008

Discovery of gene linked to adult-onset obesity

Researchers at the University of Minnesota have discovered a gene that may provide a clue as to why obesity rates increase with age. The research was published today in the Proceedings of the National Academy of Sciences.

11 Jun 2008

Mouse Model News and Research

Vitamin B deficiency may cause vascular cognitive impairment

Novel imaging reagents and technology that non-invasively locates, quantifies specific cells in the body

Bone marrow stem cells used to protect gastrointestinal tissue from autoimmune attack

NanoViricides reports HIVCide-I significantly superior to current anti-HIV three drug cocktail standard

Scientists stop age-related decline in an entire organ

How short RNAs influence many proteins

Cannabinoid cell surface receptor plays a tumor-suppressing role in human colorectal cancer

Eroded telomeres are behind dyskeratosis congentia aging syndrome

Laboratory and mouse studies show targeted drug blocks the growth of breast cancer cells that spread to the brain

Research sheds light on the molecular basis of SIDS

Zinc finger technology brings personalized HIV therapy a step closer

Transplants of mononuclear human umbilical cord blood may help Lou Gehrig's patients

New discovery could lead to new treatments for Alzheimer's

Discovery of an important factor in the development of B-cell lymphomas

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

Polyphenolics derived from red grapes may help treat Alzheimer's disease

Peregrine Pharmaceuticals awarded two new U.S. patents for targeted anti-aminophospholipid agents

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Discovery of gene linked to adult-onset obesity

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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