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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Huntington’s disease symptoms reduced by new peptide-polymer therapy

Scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington's disease, an incurable, debilitating illness that causes nerve cells to break down in the brain.

3 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

Study identifies cellular and molecular roots of individual brain connectivity differences

Researchers link microscopic protein structures and cellular interactions to individual differences in brain connectivity, offering new insights into brain function and variability.

3 Nov 2024

Clues from the Mary Rose: Bone chemistry reveals age and handedness of Tudor sailors

Researchers used Raman spectroscopy to study bone chemistry in sailors from the Mary Rose, revealing aging patterns and potential handedness impacts on clavicles.

3 Nov 2024

New pathway discovery explains MRSA's high-level antibiotic resistance

Researchers have discovered a new cell division pathway in MRSA that enables high-level resistance to β-lactam antibiotics, marking a critical insight into the persistence of these 'superbugs'.

3 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

Critical protein linked to spillover potential of animal viruses

Scientists investigating animal viruses with potential to infect humans have identified a critical protein that could enable spillover of a family of organisms called arteriviruses.

1 Nov 2024

Research uncovers new mechanism in protein aggregation linked to Parkinson's disease

A team of researchers at Kumamoto University has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease.

1 Nov 2024

Study links brain proteins to individual differences in functional connectivity

A long-standing goal of neuroscience is to understand how molecules and cellular structures on a microscale give rise to communication between brain regions at the macroscale.

1 Nov 2024

Glaucoma medication may help prevent Alzheimer's-related tau build-up

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer's disease.

1 Nov 2024

Research uncovers potential role of polyphosphate in neurodegenerative diseases

Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other neurodegenerative diseases.

1 Nov 2024

Heart attack triggers sleep increase to aid recovery

A heart attack can trigger a desire to get more sleep, allowing the heart to heal and reduce inflammation - and this happens because the heart sends special signals to the brain, according to a new Mount Sinai study.

1 Nov 2024

Research reveals role of IGFBP3 in human lung development

Researchers of the University of Barcelona and the August Pi y Sunyer Biomedical Research Institute (IDIBAPS) have shown that the IGFBP3 protein plays a relevant role in human lung development.

1 Nov 2024

Targeting necroptosis could halt nerve cell loss in Alzheimer's

Alzheimer's disease is characterized by a progressive loss of nerve cells leading to a decline in memory and cognition.

1 Nov 2024

New research reveals how Hepatitis E virus can lead to kidney disease

The hepatitis E virus affects the liver. But infected liver cells secrete a viral protein that reacts with antibodies in the blood and may form complexes that can damage the filter structure of the kidneys, as researchers from the University of Zurich and the University Hospital Zurich have proven for the first time.

1 Nov 2024

Brain actively engages with immune system to maintain health

The brain constantly engages in dialogue with the body's immune system. Such communication appears aimed at ensuring a delicate balance between defending against injury and infection and guarding healthy tissue.

1 Nov 2024

Researchers identify 4-gene signature to predict neonatal sepsis before symptoms

The study uncovers gene expression signatures that predict neonatal sepsis, highlighting the potential for early intervention to reduce mortality in infants.

31 Oct 2024

VALANX Biotech and Fina Biosolutions Introduce ClickCRM for Rapid Conjugate Vaccine Development

VALANX Biotech (VALANX), a biotech company developing novel technology for site-specific protein conjugation in drug and diagnostics discovery, and Fina Biosolutions LLC (FinaBio), experts in conjugate vaccine development and conjugate chemistry, today announced the signing of a joint IP and licensing agreement.

From VALANX Biotech 31 Oct 2024

Mapping tumor microenvironments: Uncovering spatial subclones for improved cancer treatment

Researchers investigate the spatial organization of cancer cells and the tumor microenvironment.

31 Oct 2024

Deep learning techniques transform protein structure prediction

In the rapidly advancing field of computational biology, a newly peer-reviewed review explores the transformative role of deep learning techniques in revolutionizing protein structure prediction.

30 Oct 2024