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Research roundup: Making sense (or not) of health insurance; what a full Medicaid expansion could look like; recession and coverage

Each week, KHN reporter Alvin Tran compiles a selection of recently released health policy studies and briefs.

3 Aug 2013

IQWiG dossier assessment finds no added benefit of lixisenatide

Lixisenatide (trade name: Lyxumia) has been approved in Germany since February 2013 for the treatment of type 2 diabetes mellitus in combination with oral blood-glucose lowering drugs or basal insulin when these, together with diet and exercise, do not provide adequate glycaemic control. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products, the German Institute for Quality and Efficiency in Health Care examined whether this new drug offers an added benefit over the current standard therapy.

3 Aug 2013

Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Specific mutations (N676K) in the FLT3 receptor can contribute to the development of acute myeloid leukemia. The FLT3 receptor regulates cell growth, while activating gene mutations promote the uncontrolled proliferation of white blood cells. These findings were reported in the specialist journal Blood by a group of scientists from the Helmholtz Zentrum München and the Hospital of the Ludwig Maximilians University in Munich as part of a clinical research collaboration with the German Cancer Consortium.

3 Aug 2013

Combating antibiotic resistance: an interview with Ron Najafi, CEO NovaBay Pharmaceuticals

Approximately 80 years ago the first antibiotic was discovered by Sir Alexander Fleming, for which he was justifiably awarded the Nobel Prize in medicine.

2 Aug 2013

ASH to award 2013 William Dameshek Prize to Andrew S. Weyrich

The American Society of Hematology will present the 2013 William Dameshek Prize to Andrew S. Weyrich, PhD, of The University of Utah for his seminal research on the cellular and molecular causes of blood clots.

2 Aug 2013

Longer looks: mayo's demands; 140 character death watch; posting hospital prices

Every week reporter Ankita Rao selects interesting reading from around the Web.

2 Aug 2013

Researchers now have more complete picture of mTORC1 pathway that can lead to cancer, diabetes

Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose. Disrupting this chain may offer a new approach to treating disease.

2 Aug 2013

Research: Larger lungs are associated with increased chance of survival

Transplant teams have long tried to match the size of donor lungs to the size of the recipient as closely as possible, concerned that lungs of the wrong size could lead to poor lung function and poor outcomes.

2 Aug 2013

Study shows blocking dietary sugar in tumor cells may reduce cancer risk and progression

Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine. The study, conducted in fruit flies and published in the journal Cell, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including pancreatic, breast, liver, and colon cancers

2 Aug 2013

Researchers reveal location of human blood stem cells that may improve bone marrow transplants

McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.

2 Aug 2013

New technique accelerate tissue repair, reduce costs for chronic wound management

In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing in five patients with venous ulcers.

2 Aug 2013

Children who have first elevated BP not likely to receive recommended follow-up check-up

Children who have a first elevated blood pressure at the doctor's office are not likely to receive the recommended follow-up blood pressure readings within a month, according to a study published today in Pediatrics.

2 Aug 2013

Study reveals epigenetic mechanisms contribute to chronic disease susceptibility prior to birth

If you think stress is killing you, you may be right, but what you don't know is that stress might have harmed your health even before you were born. In a new report appearing in the August 2013 issue of The FASEB Journal, Harvard researchers find that epigenetic disruptions, which are associated with chronic disease later in life, are already common at birth.

2 Aug 2013

Verinata Health receives New York's Laboratory Permit for CLIA-certified verifi prenatal test

Illumina, Inc. (NASDAQ: ILMN) today announced that Verinata Health, an Illumina company, received the Clinical Laboratory Permit from the New York State Department of Health for its CLIA-certified, CAP-accredited laboratory.

2 Aug 2013

UCLA researchers develop treatment approach for breast cancer metastasized to brain

Researchers at UCLA's Jonsson Comprehensive Cancer Center (JCCC) have successfully combined cellular therapy and gene therapy in a mouse model system to develop a viable treatment strategy for breast cancer that has metastasized, or spread, to the patient's brain.

2 Aug 2013

Deletion of a protein improves ability to fight bacteria in mice with CGD

Deletion of a protein in white blood cells improves their ability to fight the bacteria staphylococcus aureus and possibly other infections in mice with chronic granulomatous disease (CGD), according to a National Institutes of Health study. CGD, a genetic disorder also found in people, is marked by recurrent, life-threatening infections. The study's findings appear online in The Journal of Clinical Investigation.

2 Aug 2013

Researchers identify new culprit that likely plays big role in severity of asthma

MD-A new culprit has been identified that likely plays a big role in the severity of asthma-a small protein chemokine called CCL26. These findings were published in the Journal of Leukocyte Biology and represent the first demonstration that CCL26 is a potent regulator of the migration of asthmatic eosinophils, commonly observed in asthmatic airways. Results from this discovery may lead to new drug targets for the treatment of asthma.

2 Aug 2013

Study: Ultrasound treatments may prevent acute kidney injury

Ultrasound treatments may prevent acute kidney injury that commonly arises after major surgery, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that this simple and noninvasive therapy may be an effective precaution for patients at risk.

2 Aug 2013

Study: New therapeutic approach to treat prostate cancer

A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer. Conducted at Cincinnati Children's Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study appears in the journal's Aug. 2 edition.

2 Aug 2013

Portable device for point-of-care diagnostic testing to detect cancer at earliest stages

Reaching a clinic in time to receive an early diagnosis for cancer -- when the disease is most treatable -- is a global problem. And now a team of Chinese researchers proposes a global solution: have a user-friendly diagnostic device travel to the patient, anywhere in the world.

2 Aug 2013

Blood News and Research

Research roundup: Making sense (or not) of health insurance; what a full Medicaid expansion could look like; recession and coverage

IQWiG dossier assessment finds no added benefit of lixisenatide

Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Combating antibiotic resistance: an interview with Ron Najafi, CEO NovaBay Pharmaceuticals

ASH to award 2013 William Dameshek Prize to Andrew S. Weyrich

Longer looks: mayo's demands; 140 character death watch; posting hospital prices

Researchers now have more complete picture of mTORC1 pathway that can lead to cancer, diabetes

Research: Larger lungs are associated with increased chance of survival

Study shows blocking dietary sugar in tumor cells may reduce cancer risk and progression

Researchers reveal location of human blood stem cells that may improve bone marrow transplants

New technique accelerate tissue repair, reduce costs for chronic wound management

Children who have first elevated BP not likely to receive recommended follow-up check-up

Study reveals epigenetic mechanisms contribute to chronic disease susceptibility prior to birth

Verinata Health receives New York's Laboratory Permit for CLIA-certified verifi prenatal test

UCLA researchers develop treatment approach for breast cancer metastasized to brain

Deletion of a protein improves ability to fight bacteria in mice with CGD

Researchers identify new culprit that likely plays big role in severity of asthma

Study: Ultrasound treatments may prevent acute kidney injury

Study: New therapeutic approach to treat prostate cancer

Portable device for point-of-care diagnostic testing to detect cancer at earliest stages

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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