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CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

First produced only in the past decade, human induced pluripotent stem cells are capable of developing into many or even all human cell types. In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases-and eventually in treating them.

31 Jul 2013

AstraZeneca, FibroGen partner to develop, commercialize anemia drug candidate FG-4592

AstraZeneca and FibroGen today announced that they have entered into a strategic collaboration to develop and commercialize FG-4592, a first-in-class oral compound in late stage development for the treatment of anemia associated with chronic kidney disease and end-stage renal disease.

31 Jul 2013

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

The deadly condition known as pulmonary arterial hypertension (PAH), which afflicts up to 150,000 Americans each year, may be reversible by using an inhalable gene therapy, report an international team of researchers led by investigators at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

31 Jul 2013

Study: About 50% of fibromyalgia patients have nerve damage

About half of a small group of patients with fibromyalgia - a common syndrome that causes chronic pain and other symptoms - was found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy (SFPN). Unlike fibromyalgia, which has had no known causes and few effective treatments, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured.

31 Jul 2013

Male and female rats show different patterns of kidney gene expression throughout their lives

Male and female rats show different patterns of kidney gene expression throughout their lives, a study in the open access journal Biology of Sex Differences reveals. The finding could help explain some of the gender differences observed in human renal disease, and lead to improved biomarkers of kidney function.

31 Jul 2013

Combination of tPA with infusion of antiplatelet drug dissolves blood clots safely

The combination of the clot-busting drug tPA with an infusion of the antiplatelet drug eptifibatide dissolves blood clots safely and more quickly than tPA alone, a study led by University of Cincinnati (UC) researchers has found.

31 Jul 2013

NPS MedicineWise finds little or no clinical benefit in switching to rivaroxaban for stroke prevention

With oral anticoagulant rivaroxaban set to be subsidised under the Pharmaceutical Benefits Scheme (PBS) for preventing stroke, NPS MedicineWise is urging people to talk to their doctor before stopping or making any changes to their anticoagulant medicines.

30 Jul 2013

METH use can make person more susceptible to fungal lung infection

Methamphetamine use can make a person more susceptible to the lung infection cryptococcosis, according to a study published in mBio-, the online open-access journal of the American Society for Microbiology.

30 Jul 2013

New CardioChek Plus analyzer delivers rapid test results for lipids and glucose

Polymer Technology Systems, Inc. (PTS, Inc.), the U.S.-based manufacturer of the CardioChek family of point-of-care diagnostic products, introduced the CardioChek Plus analyzer today at the annual American Association for Clinical Chemistry (AACC) in Houston.

30 Jul 2013

Interferon-free treatment for genotype-1b hepatitis C patients: an interview with Professor Wulf Boecher, Boehringer Ingelheim

Genotype 1 is, worldwide, the most prevalent genotype of the hepatitis C virus. It accounts for around seventy percent of all hepatitis C infections.

30 Jul 2013

Researchers uncover genetics behind what makes some people susceptible to Takayasu arteritis

Researchers have uncovered the genetics behind what makes some people susceptible to Takayasu arteritis, a debilitating disease that can lead to poor circulation, easy tiredness in the legs and arms, organ damage and stroke.

30 Jul 2013

Hope for treatment of childhood infections may come straight from the gut: Therapeutic poop

Call it therapeutic poop, if you will, but the best hope yet for an effective treatment of childhood infections with the drug-resistant bacterium C. difficile may come straight from the gut, according to recent research.

30 Jul 2013

Different types of happiness have surprisingly different effects on human genome

A good state of mind - that is, your happiness - affects your genes, scientists say. In the first study of its kind, researchers from UCLA's Cousins Center for Psychoneuroimmunology and the University of North Carolina examined how positive psychology impacts human gene expression.

30 Jul 2013

State highlights: Mass. insurers back out of disabled adults experiment

Massachusetts health insurers' reluctance to join a national experiment to improve care for disabled lower-income adults has forced the state to scale back the program even before it starts. Massachusetts is among the first states to roll out the national program, but half the insurers that were expected to participate backed out because they feared losing money. That will mean fewer options for patients when enrollment opens for the voluntary "One Care" program in October (Conaboy, 7/29).

30 Jul 2013

NIH expands CRIC study to identify risk factors for progression of early stage CKD

Researchers from the Chronic Renal Insufficiency Cohort study are embarking on another five years of work to identify risk factors for progression of early stage chronic kidney disease, better understand the importance of reduced kidney function in older persons, and learn what role CKD may play in other illnesses that require hospitalization. CRIC is supported by the National Institutes of Health.

30 Jul 2013

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

The joints of children with the most common form of chronic inflammatory arthritis contain immune cells that resemble those of 90-year-olds, according to a new study led by researchers at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.

30 Jul 2013

Hepatitis C (HCV) testing for baby boomers: an interview with Dr. Donald Jensen, Director, Center for Liver Diseases, University of Chicago

The USPSTF agreed with the CDC that since most patients (75%) who are currently infected with hepatitis C were born between 1945 - 1965, and since risk-based screening has not been successful in identifying these individuals, that a one time age-based hepatitis C blood test was necessary.

29 Jul 2013

Saudi and UK scientists provide detailed picture of MERS coronavirus

Saudi and UK scientists provide the most detailed picture yet of the clinical and laboratory characteristics of Middle East Respiratory Syndrome (MERS) coronavirus, revealing a wide range of clinical symptoms and an extremely high death rate among patients with co-existing medical conditions.

29 Jul 2013

Study explores whether reducing smoke toxicant exposure affects biomarkers of biological effect

British American Tobacco has published the protocol for a clinical study designed to determine whether using reduced-toxicant prototype cigarettes that reduce smokers' exposure to smoke toxicants impacts biological effect (ISRCTN81286286).

29 Jul 2013

Incidence of blood cancer is significantly higher in regions near facilities that release benzene

The incidence of a particular type of blood cancer is significantly higher in regions near facilities that release the chemical benzene into the environment. That is the conclusion of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. This and other studies like it will be critical to identifying and enacting public health policies to decrease or prevent cancer.

29 Jul 2013

Blood News and Research

CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

AstraZeneca, FibroGen partner to develop, commercialize anemia drug candidate FG-4592

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

Study: About 50% of fibromyalgia patients have nerve damage

Male and female rats show different patterns of kidney gene expression throughout their lives

Combination of tPA with infusion of antiplatelet drug dissolves blood clots safely

NPS MedicineWise finds little or no clinical benefit in switching to rivaroxaban for stroke prevention

METH use can make person more susceptible to fungal lung infection

New CardioChek Plus analyzer delivers rapid test results for lipids and glucose

Interferon-free treatment for genotype-1b hepatitis C patients: an interview with Professor Wulf Boecher, Boehringer Ingelheim

Researchers uncover genetics behind what makes some people susceptible to Takayasu arteritis

Hope for treatment of childhood infections may come straight from the gut: Therapeutic poop

Different types of happiness have surprisingly different effects on human genome

State highlights: Mass. insurers back out of disabled adults experiment

NIH expands CRIC study to identify risk factors for progression of early stage CKD

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

Hepatitis C (HCV) testing for baby boomers: an interview with Dr. Donald Jensen, Director, Center for Liver Diseases, University of Chicago

Saudi and UK scientists provide detailed picture of MERS coronavirus

Study explores whether reducing smoke toxicant exposure affects biomarkers of biological effect

Incidence of blood cancer is significantly higher in regions near facilities that release benzene

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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