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Immunotherapy before and after surgery benefits NSCLC patients

People with operable non-small cell lung cancers may fare better over the next few years by receiving immunotherapy treatments before and after surgery instead of only before surgery, according to a new analysis by Johns Hopkins Kimmel Cancer Center investigators.

9 Sep 2024

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrated a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.

9 Sep 2024

Ifinatamab deruxtecan shows promising results in advanced small cell lung cancer

The antibody–drug conjugate ifinatamab deruxtecan (I-DXd) showed clinically meaningful responses in pretreated patients with extensive-stage small cell lung cancer (ES-SCLC), according to an interim analysis of the Phase 2 IDeate-Lung01 study.

9 Sep 2024

Age-related fibroblast changes in males drive aggressive melanoma

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

6 Sep 2024

A fluorescent probe for studying serotonin in depression models

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is highly sensitive and selective toward serotonin.

6 Sep 2024

Understanding the cooperation of transcription factors in gene expression

Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells.

6 Sep 2024

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.

6 Sep 2024

Artificial lymphoid organ-chips created to predict vaccine responses in humans

Researchers at the Institut Pasteur in France have developed artificial "lymphoid organ-chips" that recreate much of the human immune system's response to booster vaccines

6 Sep 2024

UC's Eric Vick receives major grants to advance research into combination therapy for leukemia

The University of Cincinnati Cancer Center's Eric Vick, MD, PhD, has been awarded a nearly $215,000 Career Development Award from the Leukemia and Lymphoma Society (LLS) and a $50,000 American Society of Clinical Oncology (ASCO) Young Investigator Award to continue research into a combination therapy treatment for acute myeloid leukemia (AML).

6 Sep 2024

Study reveals key signaling pathways driving lung cancer metastasis

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of cancer in lung adenocarcinoma, a leading cause of cancer deaths around the world.

6 Sep 2024

Novel monoclonal antibody appears effective at neutralizing numerous SARS-CoV-2 variants

A monoclonal antibody appears effective at neutralizing the numerous variants of SARS-CoV-2, as well as related viruses in animals that could pose a threat if they were to begin spreading in people.

6 Sep 2024

Tiny magnetic nanorobots show promise for treating brain aneurysms

Researchers have created nanoscale robots which could be used to manage bleeds in the brain caused by aneurysms.

6 Sep 2024

Study reveals how sex hormones regulate immune system functions

Findings indicate that testosterone therapy in trans men alters immune system responses, suggesting implications for disease susceptibility and treatment.

6 Sep 2024

Arthritis medications could reverse COVID lung damage

Arthritis drugs already available for prescription have the potential to halt lingering lung problems that can last months or years after COVID-19 infections, new research from the University of Virginia School of Medicine and Cedars-Sinai suggests.

6 Sep 2024

Cancer drug offers life-changing results for severe lupus patient

The team at Charité – Universitätsmedizin Berlin is astounded by the huge improvement seen in a female patient with severe systemic lupus erythematosus (SLE) after being treated with the cancer medication teclistamab. Not long ago, the 23-year-old was wheelchair-bound due to the autoimmune disease.

6 Sep 2024

Scientists reveal how DNA methylation drives astrocytes to become stem cells, unlocking new potential for brain repair

Researchers have discovered that DNA methylation is crucial for reprogramming astrocytes into stem cells in the adult mouse brain, especially after ischemic injury, with potential implications for regenerative medicine.

6 Sep 2024

Aging immune system fuels cancer growth

A novel study by researchers at the Icahn School of Medicine at Mount Sinai addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults.

6 Sep 2024

B Cell News and Research

Immunotherapy before and after surgery benefits NSCLC patients

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

Ifinatamab deruxtecan shows promising results in advanced small cell lung cancer

Age-related fibroblast changes in males drive aggressive melanoma

A fluorescent probe for studying serotonin in depression models

Understanding the cooperation of transcription factors in gene expression

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

Artificial lymphoid organ-chips created to predict vaccine responses in humans

UC's Eric Vick receives major grants to advance research into combination therapy for leukemia

Study reveals key signaling pathways driving lung cancer metastasis

Novel monoclonal antibody appears effective at neutralizing numerous SARS-CoV-2 variants

Tiny magnetic nanorobots show promise for treating brain aneurysms

Study reveals how sex hormones regulate immune system functions

Arthritis medications could reverse COVID lung damage

Cancer drug offers life-changing results for severe lupus patient

Scientists reveal how DNA methylation drives astrocytes to become stem cells, unlocking new potential for brain repair

Aging immune system fuels cancer growth

Study links monoclonal B-cell lymphocytosis to elevated melanoma risk

New immune cell 'atlas' may aid in the diagnosis and treatment of children with life-threatening diseases

AI reveals new drug targets for cancers with limited treatment options

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