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Targeting SALL4 protein with druglike molecules could halt tumor growth, say researchers

Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.

18 Jun 2013

Vanda presents additional data from tasimelteon Phase III studies at ENDO 2013

Vanda Pharmaceuticals Inc. presented additional data today at ENDO 2013, the Endocrine Society's 95th Annual Meeting, demonstrating that tasimelteon can entrain (synchronize) both melatonin and cortisol rhythms.

18 Jun 2013

Santarus, Pharming Group announce FDA acceptance of RUCONEST BLA

Santarus, Inc. and Pharming Group NV today announced that the U.S. Food and Drug Administration has accepted for filing the Biologics License Application for the investigational drug RUCONEST (recombinant human C1 esterase inhibitor) 50 IU/kg.

18 Jun 2013

Researchers to study benefits, side effects of four widely used therapies in adults with type 2 diabetes

UT Southwestern Medical Center researchers are seeking 150 adults with type 2 diabetes to take part in the local arm of a major national clinical trial that will compare benefits and side effects of four widely used therapies to lower blood-sugar levels.

18 Jun 2013

Two MRI measurements of abdominal aorta associated with future cardiovascular events

In a study of more than 2,000 adults, researchers found that two MRI measurements of the abdominal aorta - the amount of plaque in the vessel and the thickness of its wall - are associated with future cardiovascular events, such as a heart attack or stroke. Results of the study are published online in the journal Radiology.

18 Jun 2013

Researchers use patient-specific stem cells to correct deficient insulin-producing cells

A team from the New York Stem Cell Foundation Research Institute and the Naomi Berrie Diabetes Center of Columbia University has generated patient-specific beta cells, or insulin-producing cells, that accurately reflect the features of maturity-onset diabetes of the young.

18 Jun 2013

New study identifies possible treatment to block deposition of calcium in arterial wall

HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin.

18 Jun 2013

HPV antibodies may help identify individuals at increased risk of HPV-related oropharynx cancer

Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, which is a portion of the throat that contains the tonsils.

18 Jun 2013

Drug increases amount of energy burned by fat tissue and promotes weight loss

A drug that mimics the activity of thyroid hormone significantly increases the amount of energy burned by fat tissue and promotes weight loss, an animal study of metabolism finds. The results were presented Sunday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

Study shows clear correlation between infection levels and risk of developing mood disorders

New research shows that every third person who is diagnosed for the first time with a mood disorder has been admitted to hospital with an infection prior to the diagnosis.

18 Jun 2013

Mannitol could prevent aggregation of toxic proteins in the brain, says Tel Aviv University researcher

Mannitol, a sugar alcohol produced by fungi, bacteria, and algae, is a common component of sugar-free gum and candy. The sweetener is also used in the medical field - it's approved by the FDA as a diuretic to flush out excess fluids and used during surgery as a substance that opens the blood/brain barrier to ease the passage of other drugs.

18 Jun 2013

Men with low-risk prostate cancers can choose watchful waiting for better quality of life, study says

Many men with low-risk, localized prostate cancers can safely choose active surveillance or "watchful waiting" instead of undergoing immediate treatment and have better quality of life while reducing health care costs, according to a study by researchers at Dana-Farber Cancer Institute and Massachusetts General Hospital.

18 Jun 2013

RetroNectin reagent now available for gene therapy clinical research

In an effort to aid progress in gene therapy clinical research, representatives of Clontech laboratories, Inc. and its parent company Takara Bio Inc. announce the availability of clinical grade RetroNectin reagent for direct supply to biomedical researchers.

17 Jun 2013

Final results of PUFs clinical study of Covidien's Pipeline device published in June issue of Radiology

Covidien, a leading global provider of healthcare products, today announced that the final results of the PUFs (Pipeline for Uncoilable or Failed Aneurysms) clinical study of its Pipeline embolization device have been published in the June issue of Radiology.

17 Jun 2013

European Commission amends marketing authorisation for Celgene's REVLIMID

Celgene International Sàrl was today notified that the European Commission has amended the marketing authorisation for REVLIMID. This decision means that REVLIMID is now approved to treat patients with transfusion-dependent anaemia due to low or intermediate-1 risk myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality when other therapeutic options are insufficient or inadequate.

17 Jun 2013

Mount Sinai researchers present several new studies at ENDO 2013

Researchers from the Icahn School of Medicine at Mount Sinai will present several new studies at ENDO 2013, The Endocrine Society's Annual Meeting & Expo from June 15-18 in San Francisco.

17 Jun 2013

Researchers identify genetic mutation responsible for MDP Syndrome

National Paracycling Champion Tom Staniford has an extremely rare condition which, until now, has puzzled his doctors. He is unable to store fat under his skin - yet has type 2 diabetes - and suffered hearing loss as a child. Now, thanks to advances in genome sequencing, an international research team led by the University of Exeter Medical School has identified Tom's condition and pinpointed the single genetic mutation that causes it.

17 Jun 2013

New research reports that UnaG protein could lead to new liver test

Many scientists dream of making a single discovery that provides fundamental insight into nature, may be used to help save human lives, and can assist in the preservation of an endangered species. In new research reported in the journal Cell, a Japanese team is on the verge of accomplishing this nearly impossible feat.

17 Jun 2013

Biozoom exercises option to acquire 19.9% of Opsolution

Biozoom exercised its option, under a joint venture agreement, to acquire 19.9% of Opsolution, a research and development company dedicated to advancing spectroscopic technology.

15 Jun 2013

Mayo researchers find rheumatic condition gout may be due to flare-ups in other joints

The painful rheumatic condition gout is often associated with the big toe, but it turns out that patients at highest risk of further flare-ups are those whose gout first involved other joints, such as a knee or elbow, Mayo Clinic has found.

15 Jun 2013

Blood News and Research

Targeting SALL4 protein with druglike molecules could halt tumor growth, say researchers

Vanda presents additional data from tasimelteon Phase III studies at ENDO 2013

Santarus, Pharming Group announce FDA acceptance of RUCONEST BLA

Researchers to study benefits, side effects of four widely used therapies in adults with type 2 diabetes

Two MRI measurements of abdominal aorta associated with future cardiovascular events

Researchers use patient-specific stem cells to correct deficient insulin-producing cells

New study identifies possible treatment to block deposition of calcium in arterial wall

HPV antibodies may help identify individuals at increased risk of HPV-related oropharynx cancer

Drug increases amount of energy burned by fat tissue and promotes weight loss

Study shows clear correlation between infection levels and risk of developing mood disorders

Mannitol could prevent aggregation of toxic proteins in the brain, says Tel Aviv University researcher

Men with low-risk prostate cancers can choose watchful waiting for better quality of life, study says

RetroNectin reagent now available for gene therapy clinical research

Final results of PUFs clinical study of Covidien's Pipeline device published in June issue of Radiology

European Commission amends marketing authorisation for Celgene's REVLIMID

Mount Sinai researchers present several new studies at ENDO 2013

Researchers identify genetic mutation responsible for MDP Syndrome

New research reports that UnaG protein could lead to new liver test

Biozoom exercises option to acquire 19.9% of Opsolution

Mayo researchers find rheumatic condition gout may be due to flare-ups in other joints

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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