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A drug for heart conditions improves efficacy of melanoma therapies

A collaborative study undertaken by the Navarrabiomed Biomedical Research Center (Pamplona, Navarre), the Institute of Neurosciences CSIC-UMH (Sant Joan d'Alacant, Valencian Community) and IRB Barcelona (Barcelona, Catalonia) shows that the administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this disease.

10 Aug 2023

New mechanism discovered for brain repair after ischemic stroke

Patients often experience functional decline after an ischemic stroke, especially due to the brain's resistance to regenerate after damage.

10 Aug 2023

New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy.

10 Aug 2023

Scientists develop "universal pan-mammalian clock" to accurately estimate age in mammals

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

10 Aug 2023

Study provides clues to how harmful T cells cause heart disease

Scientists can finally hunt down a harmful kind of human T cell, thanks to new research led by scientists at La Jolla Institute for Immunology (LJI) and the Medical College of Georgia (MCG) at Augusta University.

10 Aug 2023

Autism spectrum disorder may be linked to imbalance of neurons in the brain

Using human "mini-brain" models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions.

10 Aug 2023

Scientists develop novel animal model of neurobrucellosis

Neurobrucellosis is a severe long-term complication of brucellosis, one of the most common bacterial zoonotic diseases.

10 Aug 2023

Preventing the next pandemic: swine influenza genomic surveillance essential, study shows

Researchers explored the evolutionary dynamics of swine influenza A virus (swIAV) populations in Asia's southern and eastern regions.

10 Aug 2023

Study explores the diverse expression patterns of T cell priming markers across cancers

A recent study explored transcriptomics of T-cell priming markers (TPMs) across different cancers.

10 Aug 2023

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

Researchers review existing data on the molecular basis of senescence and neurodegeneration in age-related brain diseases.

10 Aug 2023

Study detects biomarker changes nearly 30 years before symptom onset of Alzheimer’s disease

A new paper has shown how Alzheimer’s disease pathology comes into being over a period of almost three decades.

10 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Gene linked to Alzheimer's may also have fertility benefits

Previous research has revealed that the Apolipoprotein-ε4 (APOE-ε4) allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease.

9 Aug 2023

Stem cell transplants may be a promising therapeutic against Alzheimer's, study shows

In the ongoing search for a cure for Alzheimer's disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system.

9 Aug 2023

SARS-CoV-2 induces mitochondrial dysfunction in multiple organs

Since the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus, researchers have been trying to determine why this virus creates such negative long-term effects compared with most coronaviruses.

9 Aug 2023

CDK9 inhibitors: A promising new treatment for hematological malignancies

A new research perspective was published in Oncotarget's Volume 14 on August 7, 2023, entitled, "CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies."

9 Aug 2023

GABA transfer between skin cells promotes melanoma initiation

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.

9 Aug 2023

Hmga1 protein could be an important therapeutic target for osteoporosis

New research published in The FASEB Journal indicates that increasing the expression of a particular gene may help to prevent bone loss associated with postmenopausal osteoporosis.

9 Aug 2023

New treatment approach shows promise in reversing hormone resistance in breast cancer

A collaborative study between LSU Health New Orleans School of Medicine, the University of Rochester and Cellestia Biotech AG, a biopharmaceutical company headquartered in Basel, Switzerland, provides compelling evidence that combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases Rx effectiveness in experimental models of estrogen-receptor positive (ER+) and triple-negative breast cancers (TNBC), respectively.

9 Aug 2023