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Researchers identify how RecA protein helps broken DNA find way to bridge the gap

Every time a human or bacterial cell divides it first must copy its DNA. Specialized proteins unzip the intertwined DNA strands while others follow and build new strands, using the originals as templates. Whenever these proteins encounter a break - and there are many - they stop and retreat, allowing a new cast of molecular players to enter the scene.

14 Dec 2012

Scientists discover how Yersinia pestis avoids setting off immune system's early infection-alarm

The plague-causing bacteria Yersinia pestis evades detection and establishes a stronghold without setting off the body's early alarms.

14 Dec 2012

High-risk leukemia patients respond to novel drug

A third of adult leukemia patients given the novel drug quizartinib during a phase II study have achieved a composite response of either complete remission, or remission with incomplete platelet recovery or incomplete hematologic recovery, report US researchers.

14 Dec 2012

National Cheng Kung University kicks off 23rd International Conference on Genome Informatics

National Cheng Kung University kicked off GIW 2012 -- the 23rd International Conference on Genome Informatics -- at International Conference Hall Dec. 12, attracting more than 140 scholars from 10 countries including Japan, Korea, China, Singapore, Canada, America, Germany, and Australia.

14 Dec 2012

Novel antibodies can aid in early diagnosis of Sjogren's Syndrome

Patients suffering from the painful autoimmune disease, Sjogren's Syndrome, will soon be able to be properly diagnosed much earlier, thanks to the discovery of novel antibodies by researchers at the University at Buffalo and Immco Diagnostics, Inc. The breakthrough, described in a paper in the December issue of Clinical Immunology, will allow patients to be treated sooner when they are much more likely to benefit.

14 Dec 2012

Biological factors, cell behaviour drive tumour growth contributing to therapy failure and relapse

Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Centre have found a way to follow single tumour cells and observe their growth over time. By using special immune-deficient mice to propagate human colorectal cancer, they found that genetic mutations, regarded by many as the chief suspect driving cancer growth, are only one piece of the puzzle. The team discovered that biological factors and cell behaviour - not only genes - drive tumour growth, contributing to therapy failure and relapse.

14 Dec 2012

Administration of N2O + ISO appears to have negative effect on fetal development

An anesthetic regimen typically used during surgery on pregnant mothers appears to have a negative effect on the development of the fetus, according to a new study on mice conducted by neurobiologists from the National Center for Toxicological Research, in Arizona.

14 Dec 2012

Knocking out PKNP gene is the Achilles' heel of some cancers

Medical researchers at the University of Alberta have discovered that knocking out a particular "partner" gene is the Achilles' heel of some cancers.

14 Dec 2012

Cedars-Sinai scientist to study Charcot-Marie-Tooth disease

A Cedars-Sinai physician-scientist has been awarded a $3 million grant from the California Institute for Regenerative Medicine to study with new stem cell technology Charcot-Marie-Tooth disease, the most common inherited neurological disorder and which damages nerves that control muscles.

14 Dec 2012

TUBB5 gene responsible for microcephaly: IMP study

Neurobiologists at the Research institute of Molecular Pathology (IMP) in Vienna have discovered one of the key genes required to make a brain. Mutations in this gene, called TUBB5, cause neurodevelopmental disease in children.

14 Dec 2012

Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene.

14 Dec 2012

Lyncean Technologies announces first sale of Compact Light Source

Palo Alto-based Lyncean Technologies, Inc., today announced its first sale of a Compact Light Source, a miniature synchrotron X-ray source employing state-of-the-art laser-beam and electron-beam technology.

14 Dec 2012

SLU researchers to study physiological and biochemical functions in lupus

Two researchers at Saint Louis University's division of rheumatology in the department of internal medicine have been awarded a $1.8 million NIH grant to study the physiological and biochemical functions in lupus, an autoimmune disease, and develop possible new medications for its treatment.

14 Dec 2012

University of Sheffield experts recreate randomly distributed stem cell sticky spots

Randomly distributed sticky spots which are integral to the development of stem cells by maximising adhesion and acting as internal scaffolding have been artificially recreated by experts from the University of Sheffield for the first time.

14 Dec 2012

MicroRNA-218 especially low in medulloblastoma

Between the blueprint of the genome and the products of its expression lie microRNAs, which can boost or lower the rate at which genes become stuff. In fact, many cancers use microRNA to magnify the expression of faulty genes or shrink the expression of helpful genes that would otherwise suppress tumors. A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low.

14 Dec 2012

Computer simulation can predict risk of irregular heart rhythms and sudden cardiac death

A computer model of the heart wall predicted risk of irregular heart rhythms and sudden cardiac death in patients, paving the way for the use of more complex cardiac models to calculate the consequences of genetic, lifestyle and other changes to the heart.

14 Dec 2012

Scientists discover FAIM molecule as potential biomarker for bone marrow cancer

Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow.

14 Dec 2012

EZH2 protein enables advanced prostate cancers to spread without stimulation by male hormones

Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs.

14 Dec 2012

NovaDigm announces data from NDV-3 vaccine Phase 1 study on Candida and Staph infections

NovaDigm Therapeutics, a company developing innovative vaccines for fungal and bacterial infections, today announced the publication of data from its first-in-human Phase 1 study of its NDV-3 vaccine program in the journal Vaccine.

13 Dec 2012

Arginase, IDO could hold clues to help 79 million Americans with prediabetes

Two enzymes that are elevated in prediabetes could hold clues to helping the 79 million Americans with the condition avoid serious vascular complications and maybe even identify those most at risk for full-blown diabetes, researchers say.

13 Dec 2012

B Cell News and Research

Researchers identify how RecA protein helps broken DNA find way to bridge the gap

Scientists discover how Yersinia pestis avoids setting off immune system's early infection-alarm

High-risk leukemia patients respond to novel drug

National Cheng Kung University kicks off 23rd International Conference on Genome Informatics

Novel antibodies can aid in early diagnosis of Sjogren's Syndrome

Biological factors, cell behaviour drive tumour growth contributing to therapy failure and relapse

Administration of N2O + ISO appears to have negative effect on fetal development

Knocking out PKNP gene is the Achilles' heel of some cancers

Cedars-Sinai scientist to study Charcot-Marie-Tooth disease

TUBB5 gene responsible for microcephaly: IMP study

Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

Lyncean Technologies announces first sale of Compact Light Source

SLU researchers to study physiological and biochemical functions in lupus

University of Sheffield experts recreate randomly distributed stem cell sticky spots

MicroRNA-218 especially low in medulloblastoma

Computer simulation can predict risk of irregular heart rhythms and sudden cardiac death

Scientists discover FAIM molecule as potential biomarker for bone marrow cancer

EZH2 protein enables advanced prostate cancers to spread without stimulation by male hormones

NovaDigm announces data from NDV-3 vaccine Phase 1 study on Candida and Staph infections

Arginase, IDO could hold clues to help 79 million Americans with prediabetes

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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