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Engineered ICCs can improve pancreatic islet transplantation and cure diabetes mellitus

A study published in the current issue of Cell Transplantation, now freely available on-line, reports that a team of researchers in South Korea have successfully engineered islet cell clusters (ICCs) that will improve pancreatic islet transplantation and offer promise for curing diabetes mellitus.

28 Nov 2012

Injecting Wnt7a protein could prevent Duchenne muscular dystrophy

Scientists have discovered that injecting a novel human protein into muscle affected by Duchenne muscular dystrophy significantly increases its size and strength, findings that could lead to a therapy akin to the use of insulin by diabetics.

28 Nov 2012

Researchers discover alternative mechanism for Ras protein activation

The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human oncogene.

28 Nov 2012

The Neuro clinician-scientists to further research on HIV/AIDS, Parkinson's

Clinician-scientists take a unique, integrated approach that is essential to advancing science and medicine. Problems encountered in the clinic inspire research and new findings from the labs are directly applied to patients' needs.

28 Nov 2012

Study broadens understanding of how cells regulate X chromosome inactivation

In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and member of the UNC Lineberger Comprehensive Cancer Center, broadens the understanding of how cells regulate silencing of the X chromosome in a process known as X-inactivation.

28 Nov 2012

Intramyocardial injection of organ-derived stem cells after AMI improves left ventricle function

A study published in the current issue of Cell Transplantation, now freely available on-line, has found that when mesenchymal cells derived from skeletal muscle (SM-MSCs) or adipose tissue (ADSCs) were injected into the heart muscle (myocardium) of separate groups of laboratory rats that had suffered a myocardial infarction, rats in both groups experienced significantly improved left ventricle function and smaller infarct size after cell therapy.

28 Nov 2012

Gadd45g protein essential in initiating development of male sex organs

Scientists at the Institute of Molecular Biology (IMB) in Mainz have identified a protein essential for initiating the development of male sex organs. Loss of the gene Gadd45g results in complete sex reversal of male mice, making them appear female.

28 Nov 2012

Carnosic acid promotes eye health

Herbs widely used throughout history in Asian and early European cultures have received renewed attention by Western medicine in recent years. Scientists are now isolating the active compounds in many medicinal herbs and documenting their antioxidant and anti-inflammatory activities. In a study published in the journal Investigative Ophthalmology & Visual Science, Stuart A. Lipton, M.D., Ph.D. and colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) report that carnosic acid, a component of the herb rosemary, promotes eye health.

28 Nov 2012

Merrimack’s MM-302 Phase I results and MM-DX-929 preclinical data to be presented at SABCS

Merrimack Pharmaceuticals, Inc. today announced that Phase I data evaluating the novel agent MM-302 for the treatment of advanced HER2+ breast cancer and preclinical data on potential imaging and biomarker-based diagnostics will be presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium (SABCS), Dec. 4-8, 2012 in San Antonio, Texas.

28 Nov 2012

THI to launch saliva-based TeloTest in first quarter 2013

Telome Health, Inc. (THI), developer of the TeloTest diagnostic test that measures average telomere length, announces the planned launch of the saliva-based TeloTest in the first quarter of 2013. Related telomere tests, including percentage of short telomeres, would follow.

28 Nov 2012

Topically applied simvastatin enhances wound recovery in diabetic mice

Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additional disease outcomes such as diabetic foot ulcer, a significant cause of morbidity in the growing population of diabetic patients. A new study has found that topically applied simvastatin accelerates wound healing in diabetic mice, suggesting important implications for humans with diabetes.

28 Nov 2012

Study identifies gene signature associated with resistance to cancer therapies

Agendia, an innovative molecular cancer diagnostics company and leader in personalized medicine, today announced the publication in the November 21st issue of the prestigious scientific journal "Cell" of a study that identifies a gene signature that is associated with resistance to a broad range of cancer therapies in multiple cancer types.

28 Nov 2012

Amarantus demonstrates excellent diffusion profile of MANF in the striatum of rat brains

Amarantus BioSciences, Inc., a biotechnology company developing new disease-modifying treatments and diagnostics for Parkinson's disease and Traumatic Brain Injury centered on its proprietary anti-apoptosis therapeutic protein MANF, today announced that the Company has successfully completed experiments demonstrating that MANF has an excellent diffusion profile in the striatum of rat brains.

27 Nov 2012

Kinexus releases new antibody microarray kit

Kinexus Bioinformatics Corporation, a world leader in functional proteomics research, announced today the release of its first Kinex antibody microarray kit with its latest generation KAM-850 chip.

27 Nov 2012

Arginase might play a role in development of cardiovascular disease in type II diabetics

In a new study published in the scientific journal Circulation, scientists at Karolinska Institutet and Karolinska University Hospital in Sweden show that an enzyme called arginase might have a key part to play in the development of cardiovascular disease in patients who already have type II diabetes.

27 Nov 2012

Specific combination of two pharmaceutical substances show promise against multiple sclerosis

A new substance class for the treatment of multiple sclerosis and other neurodegenerative diseases now promises increased efficacy paired with fewer side effects. To achieve this, a team of scientists under the leadership of Prof. Gunter Fischer and Dr. Frank Striggow have combined two already approved pharmaceutical substances with each other using a chemical linker structure.

27 Nov 2012

Liver disease therapies: an interview with Eric Halioua, CEO of Promethera Biosciences

Liver disease is a very broad family of diseases. There are two main categories of liver disease:

27 Nov 2012

Weill Cornell Medical College dean wins Argentina's Dr. Luis Federico Leloir Prize

Dr. Laurie H. Glimcher, the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College and provost for medical affairs of Cornell University, is a winner of the Dr. Luis Federico Leloir Prize of International Cooperation in Science, Technology and Innovation from Argentina's Ministry of Science, Technology and Productive Innovation.

27 Nov 2012

New way to protect neurons that express mutant huntingtin proteins

By using a model, researchers at the University of Montreal have identified and "switched off" a chemical chain that causes neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis and dementia. The findings could one day be of particular therapeutic benefit to Huntington's disease patients. "We've identified a new way to protect neurons that express mutant huntingtin proteins," explained Dr. Alex Parker of the University of Montreal's Department of Pathology and Cell Biology and its affiliated CRCHUM Research Centre.

27 Nov 2012

Renowned biotech researcher to receive TJU's Lennox K. Black International Prize

Thomas Jefferson University will honor the renowned biotech researcher whose discoveries led to a slew of innovative drugs that revolutionized treatment including Herceptin-one of the first gene-based medications for breast cancer-with its prestigious Lennox K. Black International Prize for Excellence in Biomedical Research.

27 Nov 2012

B Cell News and Research

Engineered ICCs can improve pancreatic islet transplantation and cure diabetes mellitus

Injecting Wnt7a protein could prevent Duchenne muscular dystrophy

Researchers discover alternative mechanism for Ras protein activation

The Neuro clinician-scientists to further research on HIV/AIDS, Parkinson's

Study broadens understanding of how cells regulate X chromosome inactivation

Intramyocardial injection of organ-derived stem cells after AMI improves left ventricle function

Gadd45g protein essential in initiating development of male sex organs

Carnosic acid promotes eye health

Merrimack’s MM-302 Phase I results and MM-DX-929 preclinical data to be presented at SABCS

THI to launch saliva-based TeloTest in first quarter 2013

Topically applied simvastatin enhances wound recovery in diabetic mice

Study identifies gene signature associated with resistance to cancer therapies

Amarantus demonstrates excellent diffusion profile of MANF in the striatum of rat brains

Kinexus releases new antibody microarray kit

Arginase might play a role in development of cardiovascular disease in type II diabetics

Specific combination of two pharmaceutical substances show promise against multiple sclerosis

Liver disease therapies: an interview with Eric Halioua, CEO of Promethera Biosciences

Weill Cornell Medical College dean wins Argentina's Dr. Luis Federico Leloir Prize

New way to protect neurons that express mutant huntingtin proteins

Renowned biotech researcher to receive TJU's Lennox K. Black International Prize

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Evaluating new approaches for rare disease genomics

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