Animal Model News and Research

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Elevated level of α-synuclein aggregates in stool samples can indicate early form of Parkinson’s

The so-called isolated REM-sleep behavior disorder is a condition that can provide an indication of Parkinson's disease well in advance.

16 Feb 2023

Novel experimental platform optically records neuronal activity during brain-wide fMRI in rodents

When we daydream or revisit memories, a large group of regions within our brain "lights up," or becomes more active.

16 Feb 2023

New mouse model demonstrates clear differences in virulence among mpox virus clades

Scientists from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health have removed a major roadblock to better understanding of mpox (formerly, monkeypox).

14 Feb 2023

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Those with Usher Syndrome -- the leading hereditary cause for simultaneous deafness and blindness, for which there is no treatment -- may have a new reason for hope now that researchers have confirmed the first-ever nonhuman primate model of their disease.

13 Feb 2023

Ingestible sensor could offer an alternative to invasive procedures used to diagnose motility disorders

Engineers at MIT and Caltech have demonstrated an ingestible sensor whose location can be monitored as it moves through the digestive tract, an advance that could help doctors more easily diagnose gastrointestinal motility disorders such as constipation, gastroesophageal reflux disease, and gastroparesis.

13 Feb 2023

Researchers find a way to block anaphylaxis caused by peanut allergies

Researchers from Indiana University School of Medicine have found a way to block anaphylaxis caused by peanut allergies.

9 Feb 2023

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

About 196 million women worldwide suffer from endometriosis, a condition that typically causes pelvic pain and infertility.

25 Jan 2023

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

A recent PNAS journal study has sought to address the above-stated drawback and developed a new strategy that involves a self-assembling scaffold of proliferating cell nuclear antigen (PCNA). This technique can develop nanoparticles containing evenly incorporated heterotypic antigens.

24 Jan 2023

Powerful microscopy tool sheds light on the origins of arterial biomass in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a rare and incurable disease of the lung arteries that causes early death.

20 Jan 2023

Therapeutic small molecule can restore visual functions after optic nerve injury

Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide.

20 Jan 2023

$3 million NIH grant to support research on Alzheimer's disease

Researchers at the Beckman Institute for Advanced Science and Technology will use a unique combination of imaging techniques to study Alzheimer's disease on a scale that's never been done before.

19 Jan 2023

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Researchers successfully demonstrated that lab-grown retinal organoids made new synaptic connections, theoretically establishing their potential to treat blindness due to retinal degenerative diseases.

13 Jan 2023

UC research could lead to possible treatments for scoliosis in the future

How cells shape complex tissues and organs during embryo development, which makes us what we are, has many mysteries.

11 Jan 2023

Is platelet-rich plasma therapy beneficial in treating chronic respiratory disease?

Researchers conducted a literature review to determine whether platelet-rich plasma therapy could help slow disease progression through lung regeneration in patients with chronic respiratory disease.

4 Jan 2023

Targeting defective tau proteins may be needed to treat Alzheimer’s patients

In November, researchers reported the drug lecanemab slowed the progression of Alzheimer's disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to be able to affect the course of this relentless, incurable disease.

26 Dec 2022

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Studies on diseases that affect the human brain are usually based on animal models which cannot reproduce the complexity of human neuropathies.

22 Dec 2022

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Pancreatic cancer is one of the deadliest types of cancer - in the U.S., it is estimated that over 88 percent of people will die from the disease within five years of their diagnosis.

20 Dec 2022

Use of anti-inflammatory drugs by children may be associated with dental enamel defects

A study conducted at the University of São Paulo in Brazil and described in an article published in the journal Scientific Reports shows that anti-inflammatory drugs commonly taken by children may be associated with dental enamel defects (DEDs), currently seen in about 20% of children worldwide.

20 Dec 2022

Probiotic bacterium prevents neurodegeneration in animal model of ALS

A probiotic bacterium called Lacticaseibacillus rhamnosus HA-114 prevents neurodegeneration in the C. elegans worm, an animal model used to study amyotrophic lateral sclerosis (ALS).

20 Dec 2022

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models, according to a new study by Weill Cornell Medicine investigators.

16 Dec 2022

Animal Model News and Research

Elevated level of α-synuclein aggregates in stool samples can indicate early form of Parkinson’s

Novel experimental platform optically records neuronal activity during brain-wide fMRI in rodents

New mouse model demonstrates clear differences in virulence among mpox virus clades

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Ingestible sensor could offer an alternative to invasive procedures used to diagnose motility disorders

Researchers find a way to block anaphylaxis caused by peanut allergies

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

Powerful microscopy tool sheds light on the origins of arterial biomass in pulmonary arterial hypertension

Therapeutic small molecule can restore visual functions after optic nerve injury

$3 million NIH grant to support research on Alzheimer's disease

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

UC research could lead to possible treatments for scoliosis in the future

Is platelet-rich plasma therapy beneficial in treating chronic respiratory disease?

Targeting defective tau proteins may be needed to treat Alzheimer’s patients

Cellular models based on reprogrammed human cells could boost development of efficient therapies

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Use of anti-inflammatory drugs by children may be associated with dental enamel defects

Probiotic bacterium prevents neurodegeneration in animal model of ALS

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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