Cell Nucleus News and Research

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Researchers identify neurons essential for normal sleep

Two decades ago, Clifford B. Saper, MD/PhD, Chairman of the Department of Neurology at Beth Israel Deaconess Medical Center, and colleagues discovered a set of nerve cells they thought might be the switch that turns the brain off, allowing it to sleep.

8 Oct 2018

New method for studying the cell nucleus could improve disease detection

Researchers at New York University have found a way to measure the physical properties of the nucleus and its constituents in live human cells.

5 Oct 2018

RNA sequencing method uncovers new insights into biological events in heart disease

Scientists using a powerful new technology that sequences RNA in 20,000 individual cell nuclei have uncovered new insights into biological events in heart disease.

5 Oct 2018

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Researchers from Karolinska Institutet and Kancera AB have developed a molecule that makes cancer cells sensitive to radiotherapy. In a study published in Nature Communications, the researchers describe a new way to block cancer cells' ability to repair their DNA and thus stop the survival of cancer cells.

25 Sep 2018

Columbia University announces winners of 2018 Louisa Gross Horwitz Prize

Columbia University has decided to award the Louisa Gross Horwitz Prize 2018.

24 Sep 2018

Study shows how the drive to eat overpowers the brain’s signal to stop

University of Michigan researchers have studied two groups of brain cells that compete for the control of feeding behaviour and found that cells that drive the urge to eat overpower the ones that signal to stop.

21 Sep 2018

Study: Neural signal that urges to eat overpowers the one that says to stop

Almost everyone knows the feeling. You're at a restaurant or a holiday meal, and your stomach is telling you it's full, so logically you know you should stop eating.

21 Sep 2018

Finding epigenetic signature appears to predict inflammation risk in serious type of IBD

With an estimated 1.6 million people in the U.S. dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective.

20 Sep 2018

New study focuses on two-way gene switches controlling gene activity

Led by ICREA research professors at the Centre for Genomic Regulation, Luciano Di Croce and Marc A. Marti-Renom, the study focused on a set of genes with what's known as bivalent promoters - two-way genetic 'control switches' that are poised either to turn on in early development and rapidly drive high levels of gene activity, or to switch off and shut down the gene completely.

20 Sep 2018

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Cells need for reactions on environmental changes and a balanced system of signaling cascades within the cell. Proteins outside of the cell, on the cellular surface, inside the cellular membrane, and within the cell orchestrate many fine-tuned signaling pathways, which result in adequate reactions on the environmental conditions or changes in the organism itself.

19 Sep 2018

Researchers use larval zebrafish model to reveal role of locus coeruleus in anesthesia

The application of general anesthesia in clinical therapy has been an indispensable part of modern medicine for more than a century. However, due to the complexity of the brain and the extensive actions of general anesthetic drugs, neural mechanisms underlying general anesthesia have remained a mystery.

19 Sep 2018

Manipulating nuclear pore number could lead to new way of treating cancer

Researchers at the Salk institute have found a way to manipulate the number of nuclear pores present in the perimeter of the nucleus.

19 Sep 2018

Penn researchers find common thread linking almost all TNR expansion diseases

In a class of roughly 30 neurological disorders that includes ALS, Huntington's Disease and Fragile X Syndrome, the relevant mutant gene features sections of repeating base pair sequences known as short tandem repeats, or STRs. Healthy people have STRs of normal lengths distributed across their DNA.

19 Sep 2018

Scientists discover new molecules that work together to remove unwanted DNA

Scientists have discovered a new family of molecules that work together to precisely remove unwanted DNA during reproduction in single-celled, freshwater organisms called ciliates.

19 Sep 2018

Tweaking nuclear pores could provide new avenue to battle against cancer

If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of nuclear pores.

19 Sep 2018

MAPK pathway mediates normal kidney development, reveals study

The prevalence of kidney diseases is growing rapidly due to an aging population and an increased incidence of diseases like diabetes.

14 Sep 2018

Scientists identify how viral protein promotes fatal disease caused by Nipah and Hendra viruses

Researchers have identified how a viral protein, which plays a major role in causing deadly Nipah and Hendra virus infections, targets a critical function in human cells to suppress immune responses and promote fatal disease.

12 Sep 2018

Male and female brains are affected differently by repeated binge drinking

Gene expression in an area of the brain linked to addiction is affected differently by repeated binge drinking in males and females, finds a new study published today in Frontiers in Genetics.

10 Sep 2018

New study gives insight into metabolic interactions that occur throughout the body

A recent paper published in the scientific journal Cell gives an unprecedented insight into the metabolic interactions that occur throughout the body over 24 hours.

7 Sep 2018

Research team identifies new therapeutic target for castration-resistant prostate cancer

A collaborative research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor expression in prostate cancer cells, identifying a new therapeutic target for one of the deadliest forms of cancer among men.

7 Sep 2018

Cell Nucleus News and Research

Researchers identify neurons essential for normal sleep

New method for studying the cell nucleus could improve disease detection

RNA sequencing method uncovers new insights into biological events in heart disease

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Columbia University announces winners of 2018 Louisa Gross Horwitz Prize

Study shows how the drive to eat overpowers the brain’s signal to stop

Study: Neural signal that urges to eat overpowers the one that says to stop

Finding epigenetic signature appears to predict inflammation risk in serious type of IBD

New study focuses on two-way gene switches controlling gene activity

New chemo-optogenetic method enables multi-directional activity control of cellular processes

Researchers use larval zebrafish model to reveal role of locus coeruleus in anesthesia

Manipulating nuclear pore number could lead to new way of treating cancer

Penn researchers find common thread linking almost all TNR expansion diseases

Scientists discover new molecules that work together to remove unwanted DNA

Tweaking nuclear pores could provide new avenue to battle against cancer

MAPK pathway mediates normal kidney development, reveals study

Scientists identify how viral protein promotes fatal disease caused by Nipah and Hendra viruses

Male and female brains are affected differently by repeated binge drinking

New study gives insight into metabolic interactions that occur throughout the body

Research team identifies new therapeutic target for castration-resistant prostate cancer

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