Chromosome 3 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 3, one copy inherited from each parent, form one of the pairs. Chromosome 3 spans almost 200 million base pairs (the building blocks of DNA) and represents approximately 6.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 3 likely contains between 1,100 and 1,500 genes.

Genes on chromosome 3 are among the estimated 20,000 to 25,000 total genes in the human genome.

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Around 15 years ago, a group of researchers discovered mutant zebrafish. The eyes of these zebrafish did not develop correctly, resulting in them being significantly smaller than the eyes of wild zebrafish.

9 Aug 2022

Research progress on the three-dimensional interaction between virus and host genome

A recent study reviewed the current progress on 3D interactions between host and viral genomes.

8 Aug 2022

NIH researchers develop three-dimensional structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases.

5 Aug 2022

Study reveals the effects of an atypical mode of chromosome arrangement on genome architecture and evolution

A research team led by André Marques at the Max Planck Institute for Plant Breeding Research in Cologne, Germany, has uncovered the profound effects of an atypical mode of chromosome arrangement on genome organization and evolution.

4 Aug 2022

Fruit fly genome contains whole genomes of a kind of bacteria, study finds

A fruit fly genome is not a just made up of fruit fly DNA – at least for one fruit fly species. New research from the University of Maryland School of Medicine's (UMSOM) Institute for Genome Sciences (IGS) shows that one fruit fly species contains whole genomes of a kind of bacteria, making this finding the largest bacteria-to-animal transfer of genetic material ever discovered. The new research also sheds light on how this happens.

3 Aug 2022

Study shows cellular differences in brain development between modern humans and Neanderthals

Dresden and Leipzig researchers find that stem cells in the developing brain of modern humans take longer to divide and make fewer errors when distributing their chromosomes to their daughter cells, compared to those of Neanderthals.

29 Jul 2022

Study identifies risks in the use of CRISPR therapeutics

The researchers caution: "The CRISPR genome editing method is very effective, but not always safe. Sometimes cleaved chromosomes do not recover and genomic stability is compromised - which in the long run might promote cancer."

25 Jul 2022

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

research group led by Dr. Soichi Sano, a specially appointed lecturer in the Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka Metropolitan University, revealed that men with hematopoietic mosaic loss of Y chromosome (mLOY) — meaning men with an increase, in the blood, of cells that have lost the male sex chromosome — have a worse prognosis for heart failure due to fibrosis progression in the heart.

15 Jul 2022

Moffitt researchers reveal how RNA molecules promote the development of melanoma metastasis

Changes in DNA can lead to the development and progression of cancer. DNA serves as a template for an intermediary molecule called RNA that, in turn, codes for proteins that control all cellular processes.

15 Jul 2022

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Why a condition that frequently occurs in aging men, in which an increasing number of hematopoietic cells display a loss of the Y chromosome, is associated with increased risk of mortality and age-related diseases is now a little clearer, thanks to work in mice.

15 Jul 2022

Y chromosome loss in men can lead to deadly heart failure, research shows

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.

14 Jul 2022

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and well-being.

13 Jul 2022

New underlying cause of Wiskott-Aldrich syndrome discovered

Researchers at the Salk Institute and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have discovered a new underlying cause of Wiskott-Aldrich syndrome, a rare genetic disease that leads to bleeding and immune deficiencies in babies.

13 Jul 2022

Genetically-enhanced biocontrols can help eradicate invasive alien mammals

Invasive alien mammals can have catastrophic impacts on native flora and fauna, causing species extinctions and driving profound environmental change.

8 Jul 2022

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

An international research team coordinated by Dr. Oscar Molina and Dr. Pablo Menéndez, from the Josep Carreras Leukaemia Research Institute, identifies chromosomal abnormalities associated to relapse in a frequent subset of B-cell Acute Lymphoblastic Leukemia (B-ALL), a severe condition affecting especially children.

7 Jul 2022

The role of myostatin in female fertility

A new study discusses some of the key functions of myostatin in female reproductive health and disease.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Biologists shed light on the evolution and consequences of selfish genetic elements

The human genome is littered with "selfish genetic elements," which do not seem to benefit their hosts, but instead seek only to propagate themselves.

6 Jul 2022

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

New research by a scientist at the Milner Center for Evolution at the University of Bath suggests that "selfish chromosomes" explain why most human embryos die very early on. The study, published in PLoS, Biology, explaining why fish embryos are fine but sadly humans' embryos often don't survive, has implications for the treatment of infertility.

6 Jul 2022

New, safer CRISPR approach may help correct genetic defects in the future

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

1 Jul 2022

Chromosome 3 News and Research

Further Reading

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Research progress on the three-dimensional interaction between virus and host genome

NIH researchers develop three-dimensional structure of twinkle protein

Study reveals the effects of an atypical mode of chromosome arrangement on genome architecture and evolution

Fruit fly genome contains whole genomes of a kind of bacteria, study finds

Study shows cellular differences in brain development between modern humans and Neanderthals

Study identifies risks in the use of CRISPR therapeutics

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

Moffitt researchers reveal how RNA molecules promote the development of melanoma metastasis

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Y chromosome loss in men can lead to deadly heart failure, research shows

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

New underlying cause of Wiskott-Aldrich syndrome discovered

Genetically-enhanced biocontrols can help eradicate invasive alien mammals

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

The role of myostatin in female fertility

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Biologists shed light on the evolution and consequences of selfish genetic elements

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

New, safer CRISPR approach may help correct genetic defects in the future

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