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Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Researchers presented an overview of factors influencing emerging infectious diseases. They also highlighted the importance of molecular dynamic (MD) simulations and molecular docking (MDO) analysis for combating these diseases.

17 Oct 2022

SARS-CoV-2 envelope structural protein found to form voltage-activated and calcium-activated calcium channels

In a new study, researchers investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein activity in terms of calcium cations (Ca2+) cations.

14 Oct 2022

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

In a new study, researchers visualized the mechanism of action and inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 13 (NSP13) at high spatio-temporal resolution.

13 Oct 2022

Common diabetes medication identified as a possible treatment for atrial fibrillation

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

11 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

Zinc could improve the brain defects caused by rare genetic disorder

Pediatric encephalopathies of genetic origin cause severe motor and intellectual disabilities from birth. One of these diseases, first identified in 2013, is caused by mutations in the GNAO1 gene.

10 Oct 2022

Structural analysis of monkeypox virus H1 dual phosphatase as a pan-poxvirus target

In a new study, researchers determined the 1.8-Å resolution crystal structure of the H1 dual specific phosphatase (DSP) of monkeypox virus (MPXV) that is crucial for viral replication, making it an attractive antiviral target.

5 Oct 2022

Many diverse nanopore research directions and applications beyond DNA sequencing

In a recent Nature Nanotechnology study, researchers describe diverse applications of nanopore-based technology beyond deoxyribonucleic acid (DNA) sequencing. More specifically, the current research focuses on the advancements of this technology within chemistry, biophysics, and nanoscience.

29 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Virology of the human monkeypox virus

A new review to be posted in the Virus Research journal aims to provide an overview of the recent advances reported concerning hMPXV virology.

21 Sep 2022

What is the efficacy of bioelectronic masks for the detection of respiratory infectious diseases like COVID-19?

In a new study, researchers demonstrated the detection of respiratory infectious diseases using bioelectronic masks.

21 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

Highly sensitive mask can detect respiratory viruses in the air within 10 minutes

Scientists have created a face mask that can detect common respiratory viruses, including influenza and the coronavirus, in the air in droplets or aerosols.

19 Sep 2022

Study explores the long-term impact of telemedicine on child neurology care

Researchers from the Epilepsy Neurogenetics Initiative (ENGIN) at Children's Hospital of Philadelphia (CHOP) found that across nearly 50,000 visits, patients continued to use telemedicine effectively even with the reopening of outpatient clinics a year after the onset of the COVID-19 pandemic.

16 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development.

8 Sep 2022

How a key brain network responds to seasonal shifts in day length

A recent paper examined the difference in neuronal communication in the hypothalamic network that regulates physiological function in response to the photoperiod.

8 Sep 2022

‘He stood his ground’: California state Senator will leave office as champion of tough vaccine laws

A California lawmaker who rose to national prominence by muscling through some of the country's strongest vaccination laws is leaving the state legislature later this year after a momentous tenure that made him a top target of the boisterous and burgeoning movement against vaccination mandates.

6 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.