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Researchers identify novel molecular pathway that suppresses the spread of glioblastoma

UT Southwestern researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models.

10 Aug 2022

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

A new study revealed that the replication of the ancestral strain of SARS-CoV-2 is less efficient in nasal epithelial cells (NECs) of children.

3 Aug 2022

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Morphogens are molecules that travel from biological cell to cell to pattern tissues in the embryo. These molecules are important not only for the embryo during development, but also for the adult during tissue repair.

2 Aug 2022

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Colorectal tumors are a common adverse effect of chronic inflammation of the intestine. In a new study, researchers from Japan and China demonstrate that mice models with dendritic cell immunoreceptor (DCIR) protein deficiency are resistant to colonic tumors induced by dextran sodium sulfate and azoxymethane.

2 Aug 2022

Oligomeric molecular structure of the MOR-Gal1R complex revealed

A study published in the journal Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids.

22 Jul 2022

Is monkeypox a global public-health emergency?

A summary of available knowledge on the monkeypox virus including pathogenicity, risk to the human population, and strategies that can help limit its spread.

20 Jul 2022

What is the association between natural killer cell dysfunction and COVID-19 disease severity?

Researchers assessed the association between natural killer cell dysfunction and COVID-19 disease severity.

20 Jul 2022

Scientists evaluate immunostimulatory glycolipid against SARS-CoV-2 infection

A new study showed that 7DW8-5, an immunostimulatory glycolipid impeded three respiratory viral infections, including SARS-CoV-2, in vivo.

18 Jul 2022

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Researchers reported on the benefit of immunity developed by previous SARS-CoV-2 infection for overcoming the age-associated decline in COVID-19 vaccine effectiveness.

18 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

TRIM7 inhibits coxsackievirus and norovirus infection

In a recent study posted to the bioRxiv* preprint server, researchers elucidated the underlying mechanisms of tripartite motif containing 7 (TRIM7) activity against coxsackievirus and norovirus.

7 Jul 2022

Chicoric acid a potential candidate for COVID-19 treatment

An article under review in the Scientific Reports journal and currently available on the Research Square* preprint server reports on chicoric acid (CA) as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2022

COVID-19 impairs the insulin/IGF signaling pathway

Scientists evaluate the impact of SARS-CoV-2 on the insulin/IGF signaling pathway.

6 Jul 2022

MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Researchers fabricate highly-sensitive SERS probes to detect the PD-L1 biomarker

Recently, a team led by Prof. Huang Qing at the Institute of Intelligent Machines, Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) have reported the fabrication of ultrasensitive biosensors based on Surface-enhanced Raman Spectroscopy (SERS) to detect the cancer metastasis related programmed death ligand (PD-L1) biomarker.

1 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Identification of potent SARS-CoV-2 macrodomain inhibitors

A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) inhibitor based on structure.

30 Jun 2022

Ligand News and Research

Researchers identify novel molecular pathway that suppresses the spread of glioblastoma

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Oligomeric molecular structure of the MOR-Gal1R complex revealed

Is monkeypox a global public-health emergency?

What is the association between natural killer cell dysfunction and COVID-19 disease severity?

Scientists evaluate immunostimulatory glycolipid against SARS-CoV-2 infection

Study shows that older adults can generate robust, long-lived memory against SARS-CoV-2 following infection

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

Discovery of multiple new SARS-CoV-2 MPro inhibitors

TRIM7 inhibits coxsackievirus and norovirus infection

Chicoric acid a potential candidate for COVID-19 treatment

COVID-19 impairs the insulin/IGF signaling pathway

MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Researchers fabricate highly-sensitive SERS probes to detect the PD-L1 biomarker

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

Identification of potent SARS-CoV-2 macrodomain inhibitors

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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