Monocyte News and Research

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Targeting immune cells could lead to new treatments for pulmonary fibrosis

Northwestern Medicine scientists have demonstrated that a unique population of immune cells plays a key role in the development of pulmonary fibrosis, and showed that targeting such cells could lead to new treatments for the disease.

13 Jul 2017

Study offers insight into earliest molecular steps that lead to organ rejection

Researchers at the University of Pittsburgh School of Medicine and the University of Toronto have uncovered the first molecular steps that lead to immune system activation and eventual rejection of a transplanted organ.

23 Jun 2017

KU Leuven research reveals mechanism behind post-operative ileus

In the days following abdominal surgery, patients' intestinal contents pass more slowly or not at all. New research at KU Leuven, Belgium, has now shown that this phenomenon -- known as post-operative ileus or bowel paralysis -- is not caused by the cells previously identified as the main players.

20 Jun 2017

Hidden immune cells play key role in driving primary graft dysfunction

Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation.

15 Jun 2017

Genetic manipulation of exosomes may offer new therapeutic approach to treating pancreatic cancer

Genetic manipulation of exosomes, virus-sized particles released by all cells, may offer a new therapeutic approach to treating pancreatic cancer, according to a study at The University of Texas MD Anderson Cancer Center.

8 Jun 2017

Researchers develop new biomedical polymer to treat atherosclerosis

Researchers at Ben-Gurion University and the Sheba Medical Center have developed a new therapy to treat atherosclerosis and prevent heart failure with a new biomedical polymer that reduces arterial plaque and inflammation in the cardiovascular system.

22 May 2017

Researchers discover that microRNA can prevent excessive intestinal inflammation

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine.

9 May 2017

‘Geneva signature’ evaluates safety and immunogenicity of promising anti-Ebola virus vaccine

An international team based at Geneva University Hospitals and at the University of Geneva, Switzerland, has succeeded in defining a "signature" composed of a small number of inflammatory markers that can be monitored in order to understand how a promising anti-Ebola virus vaccine stimulates the immune system.

19 Apr 2017

Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases

Researchers in France have developed a new method that will allow doctors to detect minute amounts of a protein called interferon-a in patient samples.

18 Apr 2017

Study of interactions between chemokines pinpoints potential targets for treatment of inflammation

Signal molecules called chemokines often work in tandem to recruit specific sets of immune cells to sites of tissue damage.

7 Apr 2017

Use of FTIR spectroscopy could herald fast and easy way to spot early signs of disease

While more research is needed to confirm the findings published today in the FASEB Journal, the use of FITR could herald a fast and easy way to spot early signs of infection, cancer, and difficult to diagnose neurological conditions.

21 Mar 2017

Study shows potential way to prevent formation of scar tissue around medical implants

Medical devices implanted in the body for drug delivery, sensing, or tissue regeneration usually come under fire from the host's immune system.

20 Mar 2017

Evolution of immuno-oncology

Immuno-oncology did not exist four years ago, it's a term coined by Dr. Axel Hoos, Head of the newly defined immuno-oncology department at GSK. He is also Senior Vice President Therapeutic Area (TA) and Head for Oncology R&D. Previously, it was referred to as cancer immunotherapy, but now it is called immuno-oncology (IO).

13 Mar 2017

New RNAi treatment safely blocks ocular inflammation in mice

Scientists have developed a new RNA interference therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy.

14 Feb 2017

Exosome isolation using ultracentrifugation

In the outpatient clinic and lab, our research studies aim to understand biological functions of exosomes and membrane particles.

From Beckman Coulter Life Sciences - Centrifugation 9 Feb 2017

New research exposes cellular responses linked to bird flu vaccine

New research from Vanderbilt eavesdrops on gene expression in human immune system cells before and after vaccination against bird flu.

19 Jan 2017

Endogenous peptide inhibits atherosclerosis by reducing cholesterol levels

Cells of the innate immune system that play an important role in development of atherosclerosis contain a protein that reduces levels of cholesterol in mice - and thus helps to inhibit or mitigate the disease.

19 Jan 2017

Could pathogen infection really lead to Alzheimer’s?

New concepts of infectious disease are evolving with the realization that pathogens are key players in the development of progressive chronic diseases that originally were not thought to be infectious. Infection is well-known to be associated with numerous neurological diseases for which...

12 Jan 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

New class of monocyte cells with strange morphology may cause fibrosis

Scientists at the Immunology Frontier Research Center (IFReC) at Osaka University, Japan, report a new group of monocytes they call SatM.

22 Dec 2016