Neurodegenerative Disease News and Research

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Alternative splicing in neurodegenerative disease and the promise of RNA-based therapeutic strategies

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

Research finds link between biomarkers in vitreous humor of the eye and Alzheimer's disease

New research from Boston Medical Center found a significant correlation between biomarkers in the vitreous humor of the eye and pathologically confirmed cases of Alzheimer's disease (AD) and Chronic Traumatic Encephalopathy (CTE) in post-mortem brain and eye tissue.

16 Jun 2023

Transgenic mouse model reveals surprising new connections between peripheral nerves and the heart

Oxidative stress – characterized by elevated levels of unstable molecules called reactive oxygen species– is associated with neurodegeneration and cardiovascular disease.

14 Jun 2023

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

UBQLN2 dysfunction in ALS leads to elevated PEG10 levels, suggesting a role for retrotransposon activity in the disease. PEG10's nuclear localization alters gene expression involved in axon remodeling, implicating it as a contributing mechanism in ALS.

7 Jun 2023

Ancient, virus-like protein may contribute to ALS

More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.

7 Jun 2023

Gut bacteria toxins: A hidden trigger for Parkinson's disease?

Gut dysfunction and the presence of lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of Parkinson's disease (PD), leading to neuroinflammation and neurodegeneration. Modulating the gut microbiome and reducing LPS levels may hold potential as treatment strategies for PD.

24 May 2023

Gout unveiled as surprising culprit in neurodegenerative diseases

Research highlights the association between gout and neurodegenerative diseases, revealing that gout patients exhibit smaller brain volumes, increased brain iron markers, and a higher incidence of conditions such as dementia, Parkinson's disease, and essential tremor, particularly within the first three years after diagnosis.

22 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

New technique may reveal signs of Parkinson's disease in urine samples

A team led by researchers at Purdue University and Purdue spinoff company Tymora Analytical Operations has developed a technique that may reveal signs of Parkinson's disease in urine samples.

17 May 2023

Study sheds light on the importance of a subset of microglial cells in cognition and memory

A new study sheds light on the importance of microglia, the immune cells of the brain, in cognition and memory.

15 May 2023

Menthol inhalation improves cognitive ability in animal models of Alzheimer's disease

Researchers from Cima University of Navarra (Spain) have shown in animal models of Alzheimer's disease that inhaling menthol improves cognitive ability.

10 May 2023

Ultra-long protein fibrils are a signature of severe Alzheimer’s disease, study shows

During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.

9 May 2023

A scientific statement from the American Heart and Stroke Association on the prevalence, diagnosis, and management of poststroke cognitive impairment

Researchers reviewed the incidence, prevalence, diagnosis, and management of post-stroke cognitive impairment.

3 May 2023

U-M to launch a population-based study on Alzheimer’s disease and related dementias in India

The University of Michigan is looking to launch a population-based study on Alzheimer’s disease and related dementias in India.

21 Apr 2023

Did COVID-19-associated lockdowns increase the rate of memory decline in patients with cognitive impairments?

Researchers investigated whether COVID-19-associated lockdown measures had an impact on the cognitive decline rate.

18 Apr 2023

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

Researchers evaluated whether edible mushrooms aid in preventing neurodegenerative diseases.

18 Apr 2023

New potential therapeutic developed for diffuse intrinsic pontine glioma using ASO technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

12 Apr 2023

Study suggests potential therapeutic targets for COVID-19-related neurological pathologies

In a recent study published in the journal Molecular & Cellular Proteomics, researchers analyzed the proteins in cerebrospinal fluid (CSF) samples obtained from African green monkeys and rhesus macaques infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 to understand the neurological manifestations of coronavirus disease 2019 (COVID-19).

9 Apr 2023

Is exposure to metal associated with the risk of Parkinson's disease?

Researchers reviewed the literature on metal exposure and Parkinson's disease risk.

7 Apr 2023

New insights and emerging disease-modifying drugs for Alzheimer’s disease treatment

A recent review published in Biochemical Pharmacology summarized the ongoing research, providing insights into pathophysiology and emerging drugs for Alzheimer’s disease (AD).

31 Mar 2023