Single Nucleotide Polymorphisms News and Research

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Wake Forest, UCSD develop new genetic test for prostate cancer

Karim Kader, MD, PhD, associate clinical professor at the UC San Diego School of Medicine, together with a team of researchers from Wake Forest University School of Medicine, have developed a genetic test to predict a man's risk for prostate cancer. Use of the test could reduce the need for repeat biopsies in men who have had a negative biopsy.

18 Jul 2012

Osteoarthritis gene tic markers identified

Scientists have used data from the Arthritis Research UK Osteoarthritis Genetics study to identify five gene loci significantly associated with the development of the disease.

10 Jul 2012

23andMe identifies seven SNPs associated with breast size

Using data from its unique online research platform, 23andMe, a leading personal genetics company, has identified seven single-nucleotide polymorphisms (SNPs) significantly associated with breast size, including three SNPs also correlated with breast cancer in a genome-wide association study (GWAS) now published online in BMC Medical Genetics.

4 Jul 2012

FOXO1 gene may play an important role in pathological mechanisms of Parkinson's

A recent study led by researchers at Boston University School of Medicine (BUSM) revealed that the FOXO1 gene may play an important role in the pathological mechanisms of Parkinson's disease.

29 Jun 2012

Researchers identify genes that influence degeneration of the hippocampus

In a genome-wide association (GWA) study, researchers from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) have identified several genes which influence degeneration of the hippocampus, the part of the brain most associated with Alzheimer disease (AD).

29 Jun 2012

Illumina launches RapidTrack WGS service

Illumina, Inc. today launched the RapidTrack Whole Genome Sequencing Service, a new offering in its FastTrack Sequencing Services operation that delivers a whole human genome in less than two weeks.

From Illumina, Inc. 21 Jun 2012

$Gene variant linked to postmenopausal fracture risk$

Gene variant linked to postmenopausal fracture risk

Women who carry a variation in a gene involved in blocking bone morphogenic proteins are more likely to have fragility fractures than women without the variant, Greek research shows.

1 Jun 2012

Gender link discovered for colorectal cancer

Researchers have identified three new colorectal cancer risk loci, including one on the X-chromosome, bringing the total number of independent loci associated with the disease to 20.

30 May 2012

X-chromosome involved in development of bowel cancer

Scientists have shown for the first time that one of the sex chromosomes is involved in the development of a cancer that can afflict both genders, according to a Cancer Research UK-funded study in Nature Genetics.

28 May 2012

Overactive BAALC gene found in people with acute leukemia

A small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.

25 May 2012

Researchers identify 57 SNPs associated with autism

By focusing on the identification of common genetic variants, researchers have identified 57 single nucleotide polymorphisms (SNPs) that predict-with a high degree of certainty--the risk that siblings of children with Autism Spectrum Disorder (ASD) will also develop the condition. The findings were presented at the International Meeting for Autism Research.

18 May 2012

Scientists identify and prioritize genes associated with schizophrenia

An Indiana University-led research team, along with a group of national and international collaborators, has identified and prioritized a comprehensive group of genes most associated with schizophrenia that together can generate a score indicating whether an individual is at higher or lower risk of developing the disease.

16 May 2012

Checking for specific genetic variants can help identify women at high risk of PND

Researchers at Warwick Medical School have discovered a way of identifying which women are most at risk of postnatal depression (PND) by checking for specific genetic variants.

10 May 2012

Smokers with variants in specific genes at increased risk for hot flashes

Women who smoke and carry specific variations in the genes that impact their metabolism are at higher risk of developing hot flashes in comparison with smokers who do not carry these gene variants, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism.

3 May 2012

Two research studies on genetic components of Alzheimer's

Two research studies, co-led by UC Davis neurologist Charles DeCarli and conducted by an international team that included more than 80 scientists at 71 institutions in eight countries, has advanced understanding of the genetic components of Alzheimer's disease and of brain development. Both studies appear in the April 15 edition of the journal Nature Genetics.

16 Apr 2012

Five significant genetic associations for hypothyroidism found

Using its unique online research platform, 23andMe, a leading personal genetics company, has found five significant genetic associations for hypothyroidism in the largest known genome-wide association study of hypothyroidism conducted to date. The details of the study are now available online in the journal PLoS ONE.

9 Apr 2012

African American women more likely to have ER-negative breast cancer

American women of African ancestry are more likely than European Americans to have estrogen-receptor-negative (ER-negative) breast cancer. There continues to be discussion about the role of low levels of vitamin D in the development of breast cancer for these women.

6 Apr 2012

IntegraGen’s ARISk Test looks at 65 genetic markers associated with autism

IntegraGen, Inc., a biotechnology company dedicated to molecular biomarker discovery, today announced the launch of the ARISk- Risk Assessment Test, a gender specific, genetic screening test that looks at 65 genetic markers associated with Autism Spectrum Disorder.

5 Apr 2012

Lowering LDL at younger age can reduce risk of CHD

Coronary atherosclerosis - a hardening of the arteries due to a build-up of fat and cholesterol - can lead to heart attacks and other forms of coronary heart disease (CHD). Lowering low-density lipoprotein (LDL), or "bad" cholesterol, reduces the risk of CHD, and researchers found that lowering LDL beginning early in life resulted in a three-fold greater reduction in the risk of CHD than treatment with a statin started later in life, according to research presented today at the American College of Cardiology's 61st Annual Scientific Session.

27 Mar 2012

Obese children with PNPLA3 and GCKR genetic variants more susceptible to fatty liver disease

New research found the genetic variant Patatin-like phospholipase domain containing protein-3 (PNPLA3) acting in conjunction with the glucokinase regulatory protein (GCKR) is associated with increased susceptibility to fatty liver disease in obese children.

23 Mar 2012