Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.

6 Jul 2021

Study says mRNA COVID vaccines are effective against Lambda variant

Researchers in the United States have conducted a study suggesting that the coronavirus disease 2019 (COVID-19) vaccines that are currently being rolled out in many countries should be effective against the C.37 lineage (lambda variant) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Lack of symptoms following COVID-19 mRNA vaccination doesn't mean vaccine not working

A study conducted by researchers from Maryland in the United States has found no correlation between the symptoms that develop following vaccination against coronavirus disease 2019 (COVID-19) and the antibody responses that are generated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Scientists identify breakthrough cases of SARS-CoV-2’s delta variant in fully vaccinated individuals

In a recent study conducted at the Baylor College of Medicine, Houston, USA, scientists have identified six vaccine breakthrough cases caused by the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Dimeric IgA antibodies help identify recent SARS-CoV-2 infection

A fascinating new study, released as a preprint on the medRxiv* server, adds a highly appealing tool to the armory of detection techniques for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its validation could allow the early and accurate detection of recent or active infection, which is valuable in tracing contacts and preventing forward transmission of the virus.

5 Jul 2021

Scientists identify natural SARS-CoV-2 super immunity against 23 variants

The antibodies are capable of neutralizing a wide range of SARS-CoV-2 variants even at sub-nanomolar concentrations. In addition, the combinations of these antibodies reduce the risk of generating escape mutants in vitro. The study is published in the journal Science.

5 Jul 2021

Rapid quantification of SARS-CoV-2 Spike-specific T cells by direct peptide stimulation of whole peripheral blood

To understand both the correlates of protection induced by vaccinations and the necessary immune responses to manage the COVID-19, researchers from Singapore used an alternative method to closely evaluate the kinetics and magnitude of specific T cell responses to SARS-CoV-2 infection. Their work was posted to the bioRxiv* preprint server while awaiting peer review.

5 Jul 2021

Janssens’ COVID-19 vaccine effective against SARS-CoV-2 Delta variant

Researchers in the Netherlands have conducted a study showing that Janssen’s Ad26.COV2.S coronavirus disease 2019 (COVID‐19) vaccine was effective against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among eight individuals.

4 Jul 2021

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Researchers in the United States have conducted a study showing that the humoral (antibody) immunity induced by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – varies significantly among immunocompromised individuals.

4 Jul 2021

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

Gaurav Gaiha, MD, DPhil, a member of the Ragon Institute of MGH, MIT and Harvard, studies HIV, one of the fastest-mutating viruses known to humankind.

2 Jul 2021

NYU Abu Dhabi researchers use NMR spectroscopy to map the structure of specific nanobody

For the first time in the UAE, researchers at NYU Abu Dhabi have used nuclear magnetic resonance techniques to determine the structure of a specific nanobody, Nb23, potentially leading to a better understanding of how this small protein derived from an antibody type, found only in camelids (i.e camels, llamas, and alpacas) and sharks, can fight diseases ranging from rheumatoid arthritis, lupus and psoriasis to lymphoma and breast cancer.

2 Jul 2021

B cell depleting agents can cause altered immune responses to COVID-19 vaccines, suggests study

A new preprint, available on the medRxiv* server, describes altered responses to the use of the highly effective messenger RNA (mRNA) vaccines from Pfizer/BioNTech and Moderna in patients with multiple sclerosis on anti-CD20 (MS-aCD20) monotherapy.

2 Jul 2021

What role did the SARS-CoV-2 delta variant play in India’s devastating second wave?

A detailed report, available on the preprint server medRxiv*, describes the various facets of the second wave that set it apart from the first. The report also contains the findings of an extended SIR model that explored the potential effects of intervention at various time points in the second wave.

2 Jul 2021

Researchers introduce novel type of click reaction for living cells and organisms

Increasing our understanding of cellular processes requires information about the types of biomolecules involved, their locations, and their interactions.

2 Jul 2021

Immunity to SARS-CoV-2 could last longer than originally believed

One year after infection by SARS-CoV-2, most people maintain anti-Spike antibodies regardless of the severity of their symptoms, according to a study with healthcare workers co-led by the Barcelona Institute for Global Health (ISGlobal), the Catalan Health Institute (ICS) and the Jordi Gol Institute (IDIAP JG), with the collaboration of the Daniel Bravo Andreu Private Foundation.

2 Jul 2021

Hi-tech lab taps advanced technology to boost Singapore's future pandemic response

Nanyang Technological University, Singapore (NTU Singapore) and Pathnova Laboratories, a medical diagnostic company backed by Temasek Life Sciences Accelerator and headquartered in Temasek Life Sciences Laboratory, is contributing to Singapore's COVID-19 diagnostic capability through its partnership in a new clinical diagnostic laboratory.

2 Jul 2021

Vaccines grown in eggs can lead to an off-target antibody response

Over years of studying antibody responses against the flu in the Wilson lab at the University of Chicago, researchers kept coming up with a strange finding: antibodies that seemed to bind not only to the flu virus but to every virus the lab could throw at them.

2 Jul 2021

Is there a link between circadian rhythms and COVID-19 severity?

This study showed that the time of day of SARS-CoV-2 infection could impact the severity of the viral infection and the host immune response.

1 Jul 2021

Cryo-EM structure of neutralizing antibody 5-7 in complex with SARS CoV-2 spike

Researchers from the US recently reported the 3.7 Å resolution cryo-EM structure of an NTD-directed neutralizing antibody 5-7 that forms a complex with SARS-CoV-2 spike protein. They also presented the neutralization data against VOC and studied the recognized epitope.

1 Jul 2021

Loss of PTHrP hormone can prevent metastases, improve survival in mice with pancreatic cancer

Lowering levels of a hormone called PTHrP can prevent metastases and improve survival in mice with pancreatic cancer and could lead to a new way to treat patients, according to a study from cancer researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center and with collaborators at the University of Pennsylvania.

1 Jul 2021

Antibody News and Research

Further Reading

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Study says mRNA COVID vaccines are effective against Lambda variant

Lack of symptoms following COVID-19 mRNA vaccination doesn't mean vaccine not working

Scientists identify breakthrough cases of SARS-CoV-2’s delta variant in fully vaccinated individuals

Dimeric IgA antibodies help identify recent SARS-CoV-2 infection

Scientists identify natural SARS-CoV-2 super immunity against 23 variants

Rapid quantification of SARS-CoV-2 Spike-specific T cells by direct peptide stimulation of whole peripheral blood

Janssens’ COVID-19 vaccine effective against SARS-CoV-2 Delta variant

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

NYU Abu Dhabi researchers use NMR spectroscopy to map the structure of specific nanobody

B cell depleting agents can cause altered immune responses to COVID-19 vaccines, suggests study

What role did the SARS-CoV-2 delta variant play in India’s devastating second wave?

Researchers introduce novel type of click reaction for living cells and organisms

Immunity to SARS-CoV-2 could last longer than originally believed

Hi-tech lab taps advanced technology to boost Singapore's future pandemic response

Vaccines grown in eggs can lead to an off-target antibody response

Is there a link between circadian rhythms and COVID-19 severity?

Cryo-EM structure of neutralizing antibody 5-7 in complex with SARS CoV-2 spike

Loss of PTHrP hormone can prevent metastases, improve survival in mice with pancreatic cancer

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