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Cell therapy commercialization: Streamline your path to cell therapy commercialization

Moving your cell therapy clinical trial beyond Phase I is an exciting time, marking a significant milestone. There are many therapeutic developers working to address critical patient needs in oncology, auto-immune, regenerative medicine, and other spaces.

From Charles Rivers Laboratories Cell and Gene Therapy 28 Aug 2024

A study confirms that smoking significantly increases the risk of stroke

Findings indicate smoking elevates stroke risk, particularly in older males with comorbidities, underscoring the need for targeted prevention strategies.

28 Aug 2024

Unraveling the mystery of viral evolution

All organisms - from fungi to mammals - have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with the ability to mutate greater than any other organism. As a result, they can evade treatments or acquire resistance to once-effective antiviral medications.

28 Aug 2024

Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

CNRS scientists uncover activation mechanism of bemnifosbuvir

CNRS Scientists have deciphered the activation pathway of bemnifosbuvir, a drug candidate initially in development to treat hepatitis C virus (HCV). The findings of the research team, led by CNRS scientists, unlock new opportunities to boost the efficacy of this type of drug against other RNA viruses, such as the ones that cause Covid-19 and dengue fever.

28 Aug 2024

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

Researchers used PET imaging and proteomic analysis of cerebrospinal fluid to study amyloid β and tau tangle loads in Alzheimer's patients, identifying 127 proteins linked to disease progression. The findings highlight distinct molecular pathways and potential therapeutic targets.

28 Aug 2024

Analysis reveals viral shift behind COVID-19 pandemic end

New analysis suggests that a dramatic drop in deaths from COVID-19 between 2022 and 2023 could be attributed to an abrupt phase transition in the molecular structure of the virus' spike protein.

28 Aug 2024

Zbtb18 regulates cKit expression for HSC self renewal

The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21-tdT+ and p21-tdT− HSCs. Results show that p21-tdT+ HSCs display increased self-renewal and reconstitution abilities. Zbtb18, upregulated in p21-tdT+ HSCs, is crucial for their repopulation capability. p21 interacts with ZBTB18 to suppress cKit, influencing HSC self-renewal.

28 Aug 2024

LncRNA ZNF593-AS offers hope for heart disease treatment

The research presented in the article delves into the regulatory role of the long non-coding RNA (lncRNA) ZNF593-AS in cardiac hypertrophy and myocardial remodeling, processes that are pivotal in the progression of heart failure and other cardiovascular diseases. The study uncovers how ZNF593-AS exerts its inhibitory effects by upregulating the expression of Mitofusin 2 (Mfn2), a protein known for its role in the regulation of mitochondrial dynamics and cellular metabolism.

28 Aug 2024

Artificial intelligence differentiates cancer cells and detects early viral infections

Researchers at the Centre for Genomic Regulation (CRG), the University of the Basque Country (UPV/EHU), Donostia International Physics Center (DIPC) and the Fundación Biofisica Bizkaia (FBB, located in Biofisika Institute) have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells.

27 Aug 2024

SARS-CoV-2 evolves differently in the brain, revealing critical insights into viral tropism

Study investigates the evolution of SARS-CoV-2 within the central nervous system (CNS) compared to the lungs in mice, revealing higher viral divergence in the CNS and highlighting the critical role of the furin cleavage site (FCS) in viral tropism and compartmentalization.

27 Aug 2024

Autofluorescence imaging improves accuracy of wound debridement

Over 6.5 million Americans experience chronic wounds - wounds that do not heal after a few months.

27 Aug 2024

NIH funds study on psychedelics' potential to treat methamphetamine addiction

John McCorvy, PhD, Assistant Professor in the Department of Cell Biology, Neurobiology, and Anatomy at the Medical College of Wisconsin (MCW); Adam Halberstadt, PhD, Professor of Psychiatry at the University of California San Diego (UCSD) and Director of the UCSD Center for Psychedelic Research; and Kevin Murnane, PhD, Associate Professor of Pharmacology, Toxicology, and Neuroscience and Director of Basic Science Research for the Louisiana Addiction Research Center at LSU Health Shreveport, were recently awarded a five-year, $2.4 million research grant from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), to uncover critical insights into how psychedelics could be used as a therapeutic to treat methamphetamine addiction.

27 Aug 2024

New insights into γδ T cells could improve treatment for colorectal cancer

The most common form of colorectal cancer, microsatellite-stable colorectal cancer (MSS CRC), can currently only be treated to a limited extent with modern immunotherapies.

27 Aug 2024

Study illuminates CDCA7's role in DNA methylation

DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism.

27 Aug 2024

New techniques in RNA engineering promise longer-lasting therapies

New methods to shape RNA molecules into circles could lead to more effective and long-lasting therapies, shows a study by researchers at the University of California San Diego.

27 Aug 2024

New insights on how melanoma cells resist cancer immunotherapy

Immune checkpoint inhibitors are cancer fighting drugs that help the immune system do its job of detecting and attacking tumor cells.

27 Aug 2024

Step up your cosmetics manufacturing with OHAUS!

Compliance with complex regulations and Good Manufacturing Practices is vital for cosmetics manufacturers to ensure product safety and maintain consumer trust.

From OHAUS Corporation 27 Aug 2024

AI enhances understanding of radiation-induced cardiac arrhythmia risk in lung cancer patients

Researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

27 Aug 2024