Genes News and Research

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Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20 percent. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals are at risk of developing this deadly cancer.

27 Jul 2023

Core promoter variation may drive development of triple-negative breast cancer

TNBC is a particularly aggressive subtype of breast cancer, characterized by the absence of three key receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

26 Jul 2023

Scientists unravel step-by-step activation process of protein with deep evolutionary history

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool.

26 Jul 2023

American Heart Association grants $2.1 million to study migraines and cardiovascular disease

Existing research shows certain types of migraines can increase the risk of stroke, and there is growing evidence that they may also lead to other types of cardiovascular disease (CVD).

26 Jul 2023

Mealworm protein slows weight gain and improves metabolic health in mice

As the global population grows under a changing climate, the urgency to find sustainable protein sources is greater than ever. Plant-based "meat" and "dairy" products may be popular, but they're not the only environmentally friendly meat alternatives.

26 Jul 2023

Researchers create "synthetic embryos" from bovine pluripotent stem cells

An article published in the journal Cell Stem Cell describes the first scientific study to develop blastoids – "synthetic embryos", as they were initially (and incorrectly) called – from bovine pluripotent stem cells (PSCs).

26 Jul 2023

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Researchers evaluate imaging information and characterize skeletal proportions to assess the genetic root of these traits and their connections to each other.

26 Jul 2023

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

The study described in Scientific Reports highlights an impaired response to the hormone progesterone (P4) in cervical fibroblasts from patients with refractory cervical insufficiency (CI).

26 Jul 2023

Japanese researchers identify genetic quirk linked to severe COVID-19

Despite intensive research since the pandemic began, much remains unknown about COVID-19, particularly why it can be so severe in some cases and relatively mild in others.

25 Jul 2023

Targeting chronic endometritis: study reveals potential diagnostic markers

Researchers investigated the gene expression signatures and immune cell involvement in chronic endometritis (CE) for potential diagnostic markers.

25 Jul 2023

Single target, multiple possibilities: microRNA holds promise for epilepsy treatment

Study investigated the role of micro-ribonucleic acid (miRNA) miR-335-5p as a potential therapeutic target for epilepsy.

25 Jul 2023

New targets for psoriasis treatment? Study reveals 165 associated genes

Researchers conducted a transcriptome-wide association study.

25 Jul 2023

Unlocking the secrets of asymptomatic COVID-19 infections: HLA-B*15:01 connection revealed

Researchers describe the findings of the COVID-19 Citizen Science Study.

25 Jul 2023

Researchers uncover the biology behind insulin production

The discovery of insulin has saved the lives of millions of people with diabetes worldwide, but little is known about the first step of insulin synthesis.

25 Jul 2023

USC study reveals key details about how cancer cells metastasize

A surprising finding from USC reveals key details about how cancer cells metastasize and suggests new therapeutic approaches for halting their spread.

24 Jul 2023

Arming phages with heterologous effectors paves the way for successful UTI treatment

Study demonstrated how phage can be engineered to produce bacteriocins and cell wall hydrolases as antimicrobial effector genes.

24 Jul 2023

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Cutting-edge research at the Luxembourg Institute of Health reveals the ground-breaking therapeutic potential of the compound FL3 in inhibiting oncogene translation and rewiring cancer cell metabolism, opening up new therapeutic opportunities for leukemia patients.

24 Jul 2023

Genes may explain why some people with abdominal obesity do not develop diabetes

Conventional wisdom holds that storing fat around your belly puts you at increased risk for type 2 diabetes. But surprising new findings from the University of Virginia School of Medicine suggest that naturally occurring variations in our genes can lead some people to store fat at the waist but also protect them from diabetes.

24 Jul 2023

Breakthrough stress sensor discovery reveals new mechanism of antimicrobial resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University Singapore (NTU Singapore) and Massachusetts Institute of Technology (MIT), have discovered a new stress signaling system that enables bacteria cells to adapt and protect themselves against the immune system and certain antibiotics.

24 Jul 2023

Genetics may play a role in dietary choices

In one of the first large-scale studies of genes related to diet, researchers have uncovered almost 500 genes that appear to directly influence the foods we eat.

23 Jul 2023

Genes News and Research

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Core promoter variation may drive development of triple-negative breast cancer

Scientists unravel step-by-step activation process of protein with deep evolutionary history

American Heart Association grants $2.1 million to study migraines and cardiovascular disease

Mealworm protein slows weight gain and improves metabolic health in mice

Researchers create "synthetic embryos" from bovine pluripotent stem cells

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

Japanese researchers identify genetic quirk linked to severe COVID-19

Targeting chronic endometritis: study reveals potential diagnostic markers

Single target, multiple possibilities: microRNA holds promise for epilepsy treatment

New targets for psoriasis treatment? Study reveals 165 associated genes

Unlocking the secrets of asymptomatic COVID-19 infections: HLA-B*15:01 connection revealed

Researchers uncover the biology behind insulin production

USC study reveals key details about how cancer cells metastasize

Arming phages with heterologous effectors paves the way for successful UTI treatment

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Genes may explain why some people with abdominal obesity do not develop diabetes

Breakthrough stress sensor discovery reveals new mechanism of antimicrobial resistance

Genetics may play a role in dietary choices

eBook: Using iPSCs models for human disease research and drug discovery eBook

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