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New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

A new technology that could be used to test new treatments for human organs and bone tissue - all whilst reducing the need for animal research - has been developed by engineers at the University of Sheffield.

14 Sep 2020

Potential sea animal reservoirs for coronaviruses?

The COVID-19 pandemic has focused, yet again, intense research interest on coronaviruses, due to the high toll the novel coronavirus SARS-CoV-2 has taken on human life, health, economic well-being, and social activity. A recent paper published on the server Preprints in September 2020 reviews what is known about this viral infection in water life.

13 Sep 2020

Exploring sex differences in gene expression

Males and females share the vast majority of their genomes. Only a sprinkling of genes, located on the so-called X and Y sex chromosomes, differ between the sexes. Nevertheless, the activities of our genes--their expression in cells and tissues--generate profound distinctions between males and females.

12 Sep 2020

Study identifies gene that could decrease chances of developing alcoholic cirrhosis

Researchers at Indiana University School of Medicine are learning more about how a person's genes play a role in the possibility they'll suffer from alcoholic cirrhosis with the discovery of a gene that could make the disease less likely.

12 Sep 2020

Yale researchers identify possible treatment for Duchenne muscular dystrophy

Researchers at Yale have identified a possible treatment for Duchenne muscular dystrophy (DMD), a rare genetic disease for which there is currently no cure or treatment, by targeting an enzyme that had been considered "undruggable."

12 Sep 2020

A new approach to study the role of Neandertal DNA during development

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

11 Sep 2020

Early epigenetic changes can be detected in patients before the diagnosis of diabetes

Epigenetic changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes (T2D).

10 Sep 2020

Novel liver cancer treatment could shrink tumors in a mouse model

Hepatocellular carcinoma is a common liver cancer with poor prognosis. With symptoms not discovered until later stages, it is considered the most fatal malignant liver cancer worldwide.

10 Sep 2020

Are micro and nanoplastics accumulating in human organs and tissues?

A team of researchers spoke to News-Medical about their latest research investigating whether micro and nanoplastics are accumulating in human tissues.

10 Sep 2020

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalized transplants for children with intestinal failure, according to a study published in Nature Medicine today (Monday 7th September).

10 Sep 2020

Intravenous iron therapy does not benefit anemic patients during surgery, study finds

A global study led by researchers at The University of Western Australia has addressed the rising use of intravenous iron therapy in anemic patients during major surgery and found there is little benefit.

10 Sep 2020

CN Bio partners with Imperial College London to uncover therapeutic targets for alcoholic hepatitis

CN Bio, a leading cell culture company, that has developed single and multi-organ microphysiological systems to improve the accuracy and efficiency of drug discovery, today announced a collaboration with Imperial College London, a world-class research university.

10 Sep 2020

Metabolite signature reveals signs of multi-organ damage in COVID-19 patients

SARS-CoV-2, the virus responsible for COVID-19, can cause a wide range of symptoms, from none at all to severe respiratory stress, multi-organ failure and death.

9 Sep 2020

Researchers receive $16 million NIH grant to study link between autophagy and Alzheimer's disease

Age is the most significant risk factor for Alzheimer's disease. In the United States, approximately 1 in 10 people over the age of 65 have the disease, and the odds increase to nearly 1 in 3 for those over 85. However, the mechanisms by which aging increases risk are unknown.

9 Sep 2020

Common diabetes drug controls aspects of inflammation in mice

The diabetes drug metformin--derived from a lilac plant that's been used medicinally for more than a thousand years--has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes.

9 Sep 2020

Novel drug could improve life expectancy and quality for patients with hard-to-treat cancers

The Sheffield researchers founded the spin-out Modulus Oncology with a team of experienced biotech entrepreneurs to fast-track the drug into clinical testing within two years.

9 Sep 2020

New drug can enhance life expectancy and quality for patients with hard-to-treat cancers

A new drug which could improve life expectancy and quality for patients with hard-to-treat cancers, such as pancreatic cancer and relapsed breast cancer, has been invented by scientists at the University of Sheffield.

9 Sep 2020

High levels of blood clotting factor V in severe COVID‐19 associated with worse outcomes

Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood clots such as deep vein thrombosis or pulmonary embolism, investigators at Massachusetts General Hospital (MGH) have found.

8 Sep 2020

Limited gut inflammation in COVID-19

A new study by researchers at the Icahn School of Medicine at Mount Sinai and published on the preprint server medRxiv in September 2020 shows that gut infection with this virus produces primarily mucosal immunity but also a limited inflammatory response.

8 Sep 2020

Antibody-mediated platelet death linked to COVID-19 severity

A new study by University of Tuebingen researchers shows the strong association between platelet apoptosis and the thrombotic manifestations that may underlie critical COVID-19 illness.

7 Sep 2020

Liver News and Research

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

Potential sea animal reservoirs for coronaviruses?

Exploring sex differences in gene expression

Study identifies gene that could decrease chances of developing alcoholic cirrhosis

Yale researchers identify possible treatment for Duchenne muscular dystrophy

A new approach to study the role of Neandertal DNA during development

Early epigenetic changes can be detected in patients before the diagnosis of diabetes

Novel liver cancer treatment could shrink tumors in a mouse model

Are micro and nanoplastics accumulating in human organs and tissues?

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Intravenous iron therapy does not benefit anemic patients during surgery, study finds

CN Bio partners with Imperial College London to uncover therapeutic targets for alcoholic hepatitis

Metabolite signature reveals signs of multi-organ damage in COVID-19 patients

Researchers receive $16 million NIH grant to study link between autophagy and Alzheimer's disease

Common diabetes drug controls aspects of inflammation in mice

Novel drug could improve life expectancy and quality for patients with hard-to-treat cancers

New drug can enhance life expectancy and quality for patients with hard-to-treat cancers

High levels of blood clotting factor V in severe COVID‐19 associated with worse outcomes

Limited gut inflammation in COVID-19

Antibody-mediated platelet death linked to COVID-19 severity

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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