Mouse Model News and Research

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Gastric progenitor cells in stomach may provide cancer insights

Scientists have identified and described stem cells specific to several tissues and organs of the body - key master cells that give rise to the specialized cell types characteristic of that organ.

4 Oct 2007

Calcium deficiency may increase the tendency of advanced breast cancer to target bone

A strong skeleton is less likely to be penetrated by metastasizing cancer cells, so a fortified glass of milk might be the way to block cancer's spread, according to researchers at the ANZAC Research Institute in Concord, Australia.

3 Oct 2007

Dietary calcium could possibly prevent spread of breast cancer to bone

2 Oct 2007

Leptin plays a major role in islet cell growth and insulin secretion

A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion.

2 Oct 2007

Hearts are experts at self-preservation

Bristol researchers have identified a heart protection mechanism in mice that surgeons and cardiologists may be able to exploit to improve treatments for patients in future.

1 Oct 2007

New molecular target in blood clot formation

Researchers at the University of Illinois at Chicago College of Medicine have identified a new molecular target in blood clot formation, which seems to reduce clotting without excessive bleeding, the common side-effect of anti-clotting agents.

27 Sep 2007

Enzyme's second messenger contributes to cell overgrowth

Scientists at the University of California, San Diego (UCSD) School of Medicine have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth.

27 Sep 2007

Some cancer cells mimic stem cells to evade chemotherapy

Anti-cancer treatments often effectively shrink the size of tumors, but some might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease, according to findings presented Sept. 19 by Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences (USU) at the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

25 Sep 2007

Ancient mechanism for coping with stresses also gives cancer a boost

An ancient mechanism for coping with environmental stresses, including heat and toxic exposures, also helps cancerous tumors survive, reveals a new report in the Sept. 21, 2007, issue of Cell, a publication of Cell Press.

21 Sep 2007

Some cancer cells mimic stem cells to evade chemotherapy

Anti-cancer treatments often effectively shrink the size of tumors, but some might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease, according to findings presented in Atlanta, Georgia at the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

20 Sep 2007

Chronic infection persists by targeting stromal cell network in lymphoid organs

One of the biggest challenges to treating infectious diseases and developing preventive vaccines is the ability of many chronic infections to suppress the immune T-cell response over time.

18 Sep 2007

New understanding of gene mutation responsible for fragile X syndrome

Scientists have discovered how the gene mutation responsible for fragile X syndrome - the most common inherited form of mental retardation - alters the way brain cells communicate.

18 Sep 2007

N-cofilin molecule protects from neuronal disorders

Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly – a form of mental retardation - result from abnormal migration of nerve cells during the development of the brain.

17 Sep 2007

Unique role for blood formation gene MLL identified

All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found.

13 Sep 2007

New insight into breast cancer development in high-risk women

Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth.

12 Sep 2007

Tendons found to contain a small subset of previously unknown adult stem cells

Tendon, the cord-like tissue that connects muscle to bone, contains a small subset of previously unknown adult stem cells, scientists at the National Institute of Dental and Craniofacial Research (NIDCR) part of the National Institutes of Health, and their colleagues have discovered.

11 Sep 2007

Mouse model for schizophrenia

Scientists at Johns Hopkins have developed a mouse model for schizophrenia in which a mutated gene linked to schizophrenia can be turned on or off at will.

11 Sep 2007

C-reactive protein shown to be a potential target for cancer treatment

Scientists report that a protein best known as a common marker of inflammation plays a key role in the progression of human cancer.

11 Sep 2007

Researchers develop mouse model of autism spectrum disorders

Howard Hughes Medical Institute researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome.

10 Sep 2007

eIF4E-specific anti-sense oligonucleotides knock down cancer

A new study by Jeremy Graff and colleagues from Eli Lilly and Company has demonstrated the anti-cancer effect of a new therapeutic in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers.

5 Sep 2007