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$Encouraging results from CTI’s pacritinib phase 1 study on relapsed/refractory lymphoma$

Encouraging results from CTI’s pacritinib phase 1 study on relapsed/refractory lymphoma

Cell Therapeutics, Inc. announced today that the phase 1 study data of its highly selective oral JAK2 inhibitor pacritinib, or SB1518, showed encouraging anti-tumor activity and good tolerability in 34 patients with relapsed/refractory lymphoma.

24 Sep 2012

Researchers identify subgroups of B cells in MYC-positive germinal centers

Germinal centers are sites in the organs of the lymphatic system, formed during the course of an immune response to infection, where B cells intensely proliferate and modify their DNA in order to produce antibodies specific for the pathogen. However, it is known that the vast majority of lymphomas derive from the B cells at the germinal centers.

24 Sep 2012

Even partially matched bone marrow transplants can eliminate sickle cell disease in some patients

In a preliminary clinical trial, investigators at Johns Hopkins have shown that even partially matched bone marrow transplants can eliminate sickle cell disease in some patients, ridding them of painful and debilitating symptoms and the need for a lifetime of pain medications and blood transfusions.

24 Sep 2012

Latest research on stem cells discussed at Einstein symposium

The promise of stem cells seems limitless. If they can be coaxed into rebuilding organs, repairing damaged spinal cords and restoring ravaged immune systems, these malleable cells would revolutionize medical treatment. But stem cell research is still in its infancy, as scientists seek to better understand the role of these cells in normal human development and disease.

24 Sep 2012

Researchers solve mystery of radial glial cells

Researchers at Cold Spring Harbor Laboratory (CSHL) have solved an important piece of one of neuroscience's outstanding puzzles: how progenitor cells in the developing mammalian brain reproduce themselves while also giving birth to neurons that will populate the emerging cerebral cortex, the seat of cognition and executive function in the mature brain.

24 Sep 2012

Alzheimer's can involve mixture of proteins from different neurodegenerative diseases

Neurodegenerative diseases such as Alzheimer's or Parkinson's are characterised by the loss of nerve cells and the deposition of proteins in the brain tissue. A group of researchers led by Gabor G. Kovacs from the Clinical Institute of Neurology at the MedUni Vienna has now demonstrated that Alzheimer's disease does not just - as previously believed - involve the proteins that are attributed to Alzheimer's, but instead the condition can involve a mixture of interacting proteins from different neurodegenerative diseases.

24 Sep 2012

Natural killer cells may influence lung cancer susceptibility

Why do many heavy smokers evade lung cancer while others who have never lit up die of the disease? The question has vexed scientists for decades.

24 Sep 2012

Denosumab effective in treating giant-cell tumor of the bone

Treatment with denosumab, a drug targeted against a protein that helps promote bone destruction, decreased the number of tumor giant cells in patients with giant-cell tumor of the bone, and increased new bone formation, according to the results of a phase II study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

24 Sep 2012

Newly discovered Eilat virus harmless and potentially valuable

A mosquito sample collected three decades ago in Israel's Negev Desert has yielded an unexpected discovery: a previously unknown virus that's closely related to some of the world's most dangerous mosquito-borne pathogens but, curiously, incapable of infecting non-insect hosts.

24 Sep 2012

University of Copenhagen professors receive 2012 Carlsberg Foundations Research Prize

The Carlsberg Foundations Research Prizes 2012 goes to Professor in molecular biology Kristian Helin and Professor in international politics Ole W-ver. Each researcher receives 1 million DKK where - should be spend on further research.

24 Sep 2012

Genome-wide epigenomic screening can pinpoint thyroid disease-associated variants

Genome-wide epigenomic screening can pinpoint disease-associated variants and identify novel genetic-epigenetic interactions in autoimmune thyroid diseases, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.

24 Sep 2012

Greenhouse-grown corn seeds could help treat lysosomal storage disease

The seeds of greenhouse-grown corn could hold the key to treating a rare, life-threatening childhood genetic disease, according to researchers from Simon Fraser University.

24 Sep 2012

Thomson Reuters names Sanford-Burnham cancer researcher among 2012 Citation Laureates

Thomson Reuters has selected Erkki Ruoslahti, M.D., Ph.D., cancer researcher and distinguished professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham), as one of its 2012 Citation Laureates. Citation Laureates are scientists that Thomson Reuters has predicted to win the Nobel Prize.

24 Sep 2012

Adult stem cell therapy may benefit COPD patients

New developments in regenerative medicine are bringing about exciting, novel approaches to create therapies for hard to treat diseases. Chronic obstructive pulmonary disease (COPD) is a hard to treat disorder that progressively blocks airflow in the lungs making it increasingly difficult for an individual to breathe, and is one of the leading illnesses in the US. Yet, current treatments for COPD can only try to limit the extent of damage to the lungs, and to bring some relief from symptoms.

21 Sep 2012

Partially-matched bone marrow transplants can eliminate sickle cell disease in some patients

In a preliminary clinical trial, investigators at Johns Hopkins have shown that even partially-matched bone marrow transplants can eliminate sickle cell disease in some patients, ridding them of painful and debilitating symptoms, and the need for a lifetime of pain medications and blood transfusions. The researchers say the use of such marrow could potentially help make bone marrow transplants accessible to a majority of sickle cell patients who need them.

21 Sep 2012

NCI awards Provocative Questions grant to Mount Sinai School of Medicine researchers

Two Mount Sinai School of Medicine researchers are among a select group of scientists from around the world who have been recognized by the National Cancer Institute (NCI) for their quest to answer the most pressing questions about cancer. Stuart Aaronson, MD, Professor and Chair of Oncological Sciences and Ross Cagan, PhD, Professor of Oncological Sciences at Mount Sinai, have received the NCI's new "Provocative Questions" grant, which was established to explore the important yet less obvious questions about cancer that may have been neglected in this era of significant discovery.

21 Sep 2012

Simultaneous computer brain exercises and electromagnetic stimulation for Alzheimer's disease treatment

World Alzheimer's Day - As the planet turns its attention to World Alzheimer's Day, an emerging technology using focused computer brain exercises may offer new hope to Alzheimer's patients and their families.

21 Sep 2012

Partially-matched bone marrow transplants can eliminate sickle cell disease in some patients

21 Sep 2012

Structure and function combined is best for detecting, discriminating glaucoma

An index that combines structure and function measurements can detect perimetric and preperimetric glaucoma more accurately, and can differentiate early, moderate, and advanced disease more successfully than systems that consider either variable alone, report researchers.

21 Sep 2012

New mouse models can help scientists study MCT8 deficiency

New mouse models can help scientists study MCT8 deficiency, an inherited genetic disorder affecting children, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.

21 Sep 2012

B Cell News and Research

Encouraging results from CTI’s pacritinib phase 1 study on relapsed/refractory lymphoma

Researchers identify subgroups of B cells in MYC-positive germinal centers

Even partially matched bone marrow transplants can eliminate sickle cell disease in some patients

Latest research on stem cells discussed at Einstein symposium

Researchers solve mystery of radial glial cells

Alzheimer's can involve mixture of proteins from different neurodegenerative diseases

Natural killer cells may influence lung cancer susceptibility

Denosumab effective in treating giant-cell tumor of the bone

Newly discovered Eilat virus harmless and potentially valuable

University of Copenhagen professors receive 2012 Carlsberg Foundations Research Prize

Genome-wide epigenomic screening can pinpoint thyroid disease-associated variants

Greenhouse-grown corn seeds could help treat lysosomal storage disease

Thomson Reuters names Sanford-Burnham cancer researcher among 2012 Citation Laureates

Adult stem cell therapy may benefit COPD patients

Partially-matched bone marrow transplants can eliminate sickle cell disease in some patients

NCI awards Provocative Questions grant to Mount Sinai School of Medicine researchers

Simultaneous computer brain exercises and electromagnetic stimulation for Alzheimer's disease treatment

Partially-matched bone marrow transplants can eliminate sickle cell disease in some patients

Structure and function combined is best for detecting, discriminating glaucoma

New mouse models can help scientists study MCT8 deficiency

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