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Platinum tissue concentrations predict NSCLC treatment response

Reduced tissue platinum accumulation might explain why some patients with non-small-cell lung cancer fail to respond to platinum-based chemotherapy, research shows.

13 Sep 2012

Crizotinib may be effective treatment option for NSCLC subtype

Phase I trial results show that the chemotherapy drug crizotinib may be fast-acting and produce long-lasting treatment responses in patients with anaplastic lymphoma receptor tyrosine kinase-positive non-small-cell lung cancer.

13 Sep 2012

SOX2 gene potential therapeutic target for SCLC

Expression of the Sry-related HMG box 2 gene is higher in small-celllung cancer tissue samples than in non-cancerous lung tissue samples, according to findings from a genetic study.

13 Sep 2012

Solubilized curcumin shrinks lung tumors in mice

Belgian researchers report that orally administered curcumin can reduce the size of lung cancer tumors in mice.

13 Sep 2012

Addition of sorafenib to chemotherapy does not prolong survival

The addition of sorafenib to gemcitabine/cisplatin fails to provide any additional benefit in chemotherapy-naïve patients with nonsquamous non-small-cell lung cancer, research shows.

13 Sep 2012

FDG–PET/CT improves staging and modifies radiotherapy management

The addition of FDG–positron emission tomography/computed tomography revised radiotherapy decision-making and enhanced tumor staging capabilities in patients with non-small-cell lung cancer, research shows.

13 Sep 2012

Researchers hold new implications for pathogenesis of myotonic dystrophy

An important breakthrough could help in the fight against myotonic dystrophy. The discovery, recently published in the prestigious scientific journal Cell, results from an international collaboration between researchers at the IRCM, the Massachusetts Institute of Technology (MIT), the University of Southern California and Illumina.

13 Sep 2012

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

In an advance toward development of a nasal spray that protects against infection with influenza and spread of the disease, scientists are reporting identification of a substance that activates the first-line defense system against infection inside the nose. They describe effects of a synthetic form of a natural substance found in bacterial cell walls in ACS' journal Molecular Pharmaceutics.

13 Sep 2012

Sanford-Burnham professor to develop personalized models of inherited heart conditions

The California Institute for Regenerative Medicine (CIRM) has awarded a $1.58 million grant to Huei-Sheng Vincent Chen, Ph.D., associate professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham). Chen's proposal was one of 28 new projects funded as part of CIRM's Basic Biology IV awards program, which supports basic research aimed at increasing our understanding of stem cells and how to work with them.

13 Sep 2012

Brigham Young University scientists discover cellular cause of birth defects

The cellular cause of birth defects like cleft palates, missing teeth and problems with fingers and toes has been a tricky puzzle for scientists. Now Professor Emily Bates and her biochemistry students at Brigham Young University have placed an important piece of the developmental puzzle. They studied an ion channel that regulates the electrical charge of a cell. In a new study published by the journal Development, they show that blocking this channel disrupts the work of a protein that is supposed to carry marching orders to the nucleus.

13 Sep 2012

Endocannabinoids may contribute to pregnancy complications

New research indicates marijuana-like compounds called endocannabinoids alter genes and biological signals critical to the formation of a normal placenta during pregnancy and may contribute to pregnancy complications like preeclampsia.

13 Sep 2012

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Menachem Shoham, PhD, associate professor of biochemistry at Case Western Reserve University School of Medicine, has discovered novel antivirulence drugs that, without killing the bacteria, render Methicillin Resistant Staphylococcus Aureus (MRSA) and Streptococcus pyogenes, commonly referred to as strep, harmless by preventing the production of toxins that cause disease.

13 Sep 2012

Some gut microbes increase absorption of dietary fats

You may think you have dinner all to yourself, but you're actually sharing it with a vast community of microbes waiting within your digestive tract. A new study from a team including Carnegie's Steve Farber and Juliana Carten reveals that some gut microbes increase the absorption of dietary fats, allowing the host organism to extract more calories from the same amount of food.

13 Sep 2012

Changes in physical characteristics of regulatory T cell can predict MDS progression risk

Researchers at Moffitt Cancer Center and colleagues have discovered that changes in the physical characteristics of the effector memory regulatory T cell can predict the progression risk of myelodysplastic syndromes (MDS) to acute myeloid leukemia. The finding could improve prognostication for patients with MDS and better inform therapeutic decision making.

13 Sep 2012

New research offers ways in which investigators can reduce amount of Cd in foods

A number of environmental toxins pose considerable health threats to humans, and the heavy metal cadmium (Cd) ranks high on the list. Most of us are exposed to it through plant-derived foods such as grains and vegetables. Now, new research offers ways in which investigators can reduce the amount of Cd found in the food we eat, according to a review published online September 12th in the Cell Press journal Trends in Plant Science.

13 Sep 2012

Combination chemotherapy confirmed viable for penile cancer

A combination of cisplatin and 5-fluorouracil is an effective and well-tolerated regimen for patients with squamous cell carcinoma of the penis, show study findings.

12 Sep 2012

Ageing in neurons follows same rules as in senescing fibroblasts

The ageing process has its roots deep within the cells and molecules that make up our bodies. Experts have previously identified the molecular pathway that react to cell damage and stems the cell's ability to divide, known as cell senescence.

12 Sep 2012

Molecular beacons allow scientists to monitor gene expression during stem cell transformation

A novel set of custom-designed "molecular beacons" allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly.

12 Sep 2012

Popular Science magazine names University of Minnesota chemist among ‘Brilliant 10’

University of Minnesota chemist Christy Haynes has been named one of Popular Science magazine's "Brilliant 10," an honor that recognizes an elite group of young scientists whose research is expected to dramatically impact their fields. Haynes' profile was published today on the PopSci website and is featured in the Popular Science magazine now on newsstands.

12 Sep 2012

Gene therapy regimen can safely restore immune systems to children with Bubble Boy disease

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called "Bubble Boy" disease, a life threatening condition that if left untreated can be fatal within one to two years.

12 Sep 2012

B Cell News and Research

Platinum tissue concentrations predict NSCLC treatment response

Crizotinib may be effective treatment option for NSCLC subtype

SOX2 gene potential therapeutic target for SCLC

Solubilized curcumin shrinks lung tumors in mice

Addition of sorafenib to chemotherapy does not prolong survival

FDG–PET/CT improves staging and modifies radiotherapy management

Researchers hold new implications for pathogenesis of myotonic dystrophy

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

Sanford-Burnham professor to develop personalized models of inherited heart conditions

Brigham Young University scientists discover cellular cause of birth defects

Endocannabinoids may contribute to pregnancy complications

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Some gut microbes increase absorption of dietary fats

Changes in physical characteristics of regulatory T cell can predict MDS progression risk

New research offers ways in which investigators can reduce amount of Cd in foods

Combination chemotherapy confirmed viable for penile cancer

Ageing in neurons follows same rules as in senescing fibroblasts

Molecular beacons allow scientists to monitor gene expression during stem cell transformation

Popular Science magazine names University of Minnesota chemist among ‘Brilliant 10’

Gene therapy regimen can safely restore immune systems to children with Bubble Boy disease

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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