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Manipulating 3D Printed Organoid Microenvironments

Organoids are 3-dimensional (3D) clusters of stem cells that come together and emulate the microenvironment within individual organs, whether that be liver, kidney, heart, gut or other specific organs.

From Manchester BIOGEL 28 Aug 2020

Blood thinners help reduce the risk of COVID-19 deaths, study finds

Now, a new study by a team of researchers at the Mount Sinai Health System in New York has shown that blood thinners may reduce the risk of death by up to 50 percent among severely ill hospitalized COVID-19 patients.

27 Aug 2020

Study identifies three clinical course variations in patients with acute decompensated cirrhosis

When the body can no longer compensate the gradual failure of the liver caused by liver cirrhosis, there is a high risk of acute decompensated liver cirrhosis.

27 Aug 2020

Two discoveries can lead to a new wave of more-complex organoid development

In back-to-back reports published Aug. 27, 2020, in Nature Communications, a team of scientists from Cincinnati Children's and Japan report discoveries that will be vital to a new wave of more-complex organoid development.

27 Aug 2020

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

Researchers at the Universities of Maynooth and Bonn discover a new connection in muscular dystrophy Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance.

27 Aug 2020

New discovery could help protect the liver from fructose-induced diseases

A team of international researchers including Monash University academics has discovered that, contrary to previous belief, fructose causes liver toxicity by changing the barrier function of the intestine.

27 Aug 2020

Researchers identify how promising therapy may work to improve adverse effects of NAFLD

A team led by researchers at Massachusetts General Hospital (MGH) has taken an important step forward in the goal of developing a potential treatment for non-alcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease.

26 Aug 2020

Study reveals a troubling connection between coronavirus and obesity

A review of COVID-19 studies reveals a troubling connection between two health crises: coronavirus and obesity.

26 Aug 2020

Researchers identify three forms of disease progression for acute decompensated liver cirrhosis

When the body can no longer compensate the gradual failure of the liver caused by liver cirrhosis, there is a high risk of acute decompensated liver cirrhosis.

26 Aug 2020

BM32 vaccine against grass pollen allergy could be potential treatment for hepatitis B infection

Chronic hepatitis B infections represent a global health problem that could hitherto only be treated by chemotherapy.

26 Aug 2020

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

In May 2019, the U.S. Food and Drug Administration approved a gene replacement therapy for the inherited, progressive neuromuscular disease 5q-linked spinal muscular atrophy.

25 Aug 2020

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

Patients who develop cytomegalovirus infections after allogeneic stem cell transplantation may be able to develop an immunity against the virus, strengthen their immune system and reduce reliance on strong antiviral medications, a team of cellular-therapy specialists from Roswell Park Comprehensive Cancer Center has found.

25 Aug 2020

Macrophage programming is more complex than previously thought

Macrophages are white blood cells that, depending on the signals they get from the immune system, become specialized in either increasing or decreasing inflammation.

25 Aug 2020

Genomic analysis reveals many animal species vulnerable to SARS-CoV-2

Now, a new genomics study by University of California, Davis, California researchers identifies a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins.

24 Aug 2020

Researchers identify potential drug target for curtailing cancer metastasis

Researchers led by Ludwig Chicago Co-director Ralph Weichselbaum and Ronald Rock of the University of Chicago have identified in preclinical studies a potential drug target for curtailing cancer metastasis.

24 Aug 2020

Excessive fructose consumption can result in non-alcoholic fatty liver disease

Excessive consumption of fructose - a sweetener ubiquitous in the American diet - can result in non-alcoholic fatty liver disease (NAFLD), which is comparably abundant in the United States.

24 Aug 2020

Large animals with ailing livers can grow new organ in lymph nodes from their own hepatocytes

Hepatocytes -- the chief functional cells of the liver -- are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply.

24 Aug 2020

VUMC receives $34 million grant for nationwide convalescent plasma study

Vanderbilt University Medical Center has been awarded a one-year, $34-million grant by the National Center for Advancing Translational Sciences, part of the National Institutes of Health, to conduct a nationwide study of "convalescent plasma" as a treatment for COVID-19.

21 Aug 2020

Key molecule can be used to assess prognosis of triple negative breast cancer

Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.

21 Aug 2020

Study could reveal brain cells and circuits that influence human health and metabolism in response to dietary changes

A new federally funded study could reveal the nervous system cells and circuits in our brains that influence our metabolism and health in response to dietary changes.

21 Aug 2020

Liver News and Research

Manipulating 3D Printed Organoid Microenvironments

Blood thinners help reduce the risk of COVID-19 deaths, study finds

Study identifies three clinical course variations in patients with acute decompensated cirrhosis

Two discoveries can lead to a new wave of more-complex organoid development

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

New discovery could help protect the liver from fructose-induced diseases

Researchers identify how promising therapy may work to improve adverse effects of NAFLD

Study reveals a troubling connection between coronavirus and obesity

Researchers identify three forms of disease progression for acute decompensated liver cirrhosis

BM32 vaccine against grass pollen allergy could be potential treatment for hepatitis B infection

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

Macrophage programming is more complex than previously thought

Genomic analysis reveals many animal species vulnerable to SARS-CoV-2

Researchers identify potential drug target for curtailing cancer metastasis

Excessive fructose consumption can result in non-alcoholic fatty liver disease

Large animals with ailing livers can grow new organ in lymph nodes from their own hepatocytes

VUMC receives $34 million grant for nationwide convalescent plasma study

Key molecule can be used to assess prognosis of triple negative breast cancer

Study could reveal brain cells and circuits that influence human health and metabolism in response to dietary changes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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