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Vinculin protein levels increase with age to alter shape, performance of cardiac muscle cells

The human heart makes precious few new cells but manages to generate billions of life-sustaining beats as it grows old.

18 Jun 2015

Ragweed pollen can trigger strong allergic reactions

Ragweed (Ambrosia artemisiifolia) - an otherwise unremarkable plant - produces pollen that can trigger strong allergic reactions such as asthma even in very small quantities. Scientists from Technische Universität München (TUM) and Helmholtz Zentrum München have now published a joint study showing that the substance previously identified as the major allergen only induces such a vigorous allergic response in combination with the adenosine also present in the pollen.

18 Jun 2015

Findings could lead to treatments for chronic pain caused by nerve damage

Non-narcotic treatments for chronic pain that work well in people, not just mice, are sorely needed. Drawing from human pain genetics, an international team led by Boston Children's Hospital demonstrates a way to break the cycle of pain hypersensitivity without the development of addiction, tolerance or side effects.

18 Jun 2015

Melanoma patients with high levels of H2A.Z.2 protein less likely to survive

Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a study led by researchers at Icahn School of Medicine at Mount Sinai and published online in the journal Molecular Cell.

18 Jun 2015

Rare form of autoimmune syndrome may be tied to mutations in AIRE gene

A hereditary autoimmune disease that was thought to be exceedingly rare may have a less severe form that affects one in 1,000 people or even more, according to new research conducted at the Weizmann Institute of Science, in Israel, and the University of Bergen, in Norway.

18 Jun 2015

Optimised ChIP protocols for qPCR and sequencing

Chromatrap®, a business unit of Porvair Sciences, has announced a new web page that brings together protocols developed using their proprietary solid state chromatin immunoprecipitation (ChIP) technology.

From Chromatrap® - Porvair Sciences Ltd 17 Jun 2015

New tissue 'scaffold' technology could one day help produce large organs

Scientists have developed a new tissue 'scaffold' technology that could one day enable the engineering of large organs. Research led by the Universities of Bristol and Liverpool has shown that it is possible to combine cells with a special scaffold to produce living tissue in the laboratory. It is hoped this can then be implanted into patients as a way of replacing diseased parts of the body.

17 Jun 2015

Ruhr-Universität Bochum scientists develop mouse model to investigate SCA6

Scientists at the Ruhr-Universität Bochum established a mouse model for the human disease SCA6. SCA6 is characterised by movement deficits and caused by similar genetic alterations as Chorea Huntington. The mouse model will be used to investigate the disease mechanisms.

17 Jun 2015

ALK1 protein determines the extent of breast tumour's spread in the body

For breast cancer to be fatal, the tumour has to send out metastases to other parts of the body. The cancer cells are spread via the blood vessels, and a research team at Lund University in Sweden has now proven that the protein ALK1 determines the extent of the tumour's spread in the body.

17 Jun 2015

New study reports more practical approach to heal the heart after a heart attack

Stem cell have been the main focus of healing therapy research because they can morph into new cells, and using a patient's own stem cells will not induce an autoimmune response. For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel because the heart is easily accessible. While stem cells show promise for heart attack treatment, the process of harvesting and reintroducing the cells—which can take days or weeks—is too slow for this window.

17 Jun 2015

La Jolla Institute researchers identify molecular pathway that maintains Treg cells' function

Regulatory T cells (Treg cells) are part of the system of checks and balances that prevents the immune response from going overboard and causing autoimmune disease. Although critically important for shaping the immune response and maintaining self-tolerance, how they hold on to their immune-suppressive powers had remained unclear.

17 Jun 2015

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Aging can cause many changes to the body, including obesity and a loss of lean mass. Now, a group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans.

17 Jun 2015

Regulatory T cells critical for the immune system's ability to fight off future pathogen attacks

Just as militaries need to have trained, experienced soldiers ready for future wars, making sure that the immune system has enough battle-ready T cells on hand is important for fast-acting, more effective vaccines, according to Penn State researchers.

17 Jun 2015

TGen, Phoenix Children's Hospital developing new methods to store and transport blood samples

The Translational Genomics Research Institute and Phoenix Children's Hospital are developing new economical methods of preserving, storing and transporting high-quality blood plasma proteins for use in diagnosing and treating disease.

17 Jun 2015

Researchers reveal that Helicobacter pylori infection can lead to gastric cancer

Around half of the global population is chronically infected with the stomach bacterium Helicobacter pylori, almost 1 percent of whom go on to develop gastric adenocarcinoma, one of the deadliest forms of cancer. Usually it takes many decades for the cancer to develop, making it difficult to pinpoint exactly how it is linked to an infection.

17 Jun 2015

TSRI study confirms role of Rhes protein in Huntington's disease

Huntington's disease attacks the part of the brain that controls movement, destroying nerves with a barrage of toxicity, yet leaves other parts relatively unscathed.

17 Jun 2015

Researchers focus on novel techniques to combat global blood shortage

Red blood cells are the cells responsible for transporting oxygen to all the organs of the body. Red blood cells are the body's most common cell type: no less than 20 billion red blood cells die and are regenerated every day.

17 Jun 2015

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Since the 2009 discovery that energy-burning brown fat can be active in adults, research has raced ahead to understand this tissue and exploit it to treat the epidemic of obesity. Active brown fat also may assist in directly easing the burden of diabetes and related metabolic diseases by lowering the levels of glucose and fatty acids in the bloodstream. But progress in studying human brown fat often has been slowed by difficulties in obtaining and studying samples of the human cells that develop into brown fat.

17 Jun 2015

Potential mosquito-based malaria vaccine could be a step closer

A promising type of vaccine designed to eradicate malaria by blocking parasite transmission could be a step closer, as a result of experts uncovering new information about the targeted protein.

17 Jun 2015

CQDM, OCE grant $1.5M to speed up drug discovery and development in Quebec-Ontario Life Sciences Corridor

CQDM and Ontario Centres of Excellence will fund five highly innovative and unconventional game-changing research and development projects to accelerate drug discovery in the Quebec-Ontario Life Sciences Corridor. Partners are granting $1.5M to Quebec-based and, for the first time, Ontario-based researchers thanks to the partnership with OCE through CQDM's 2014 Explore Program, one of CQDM's flagship programs focusing on early concept validation of cutting-edge technologies that address the most crucial needs in drug discovery and development.

17 Jun 2015

G Protein News and Research

Vinculin protein levels increase with age to alter shape, performance of cardiac muscle cells

Ragweed pollen can trigger strong allergic reactions

Findings could lead to treatments for chronic pain caused by nerve damage

Melanoma patients with high levels of H2A.Z.2 protein less likely to survive

Rare form of autoimmune syndrome may be tied to mutations in AIRE gene

Optimised ChIP protocols for qPCR and sequencing

New tissue 'scaffold' technology could one day help produce large organs

Ruhr-Universität Bochum scientists develop mouse model to investigate SCA6

ALK1 protein determines the extent of breast tumour's spread in the body

New study reports more practical approach to heal the heart after a heart attack

La Jolla Institute researchers identify molecular pathway that maintains Treg cells' function

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Regulatory T cells critical for the immune system's ability to fight off future pathogen attacks

TGen, Phoenix Children's Hospital developing new methods to store and transport blood samples

Researchers reveal that Helicobacter pylori infection can lead to gastric cancer

TSRI study confirms role of Rhes protein in Huntington's disease

Researchers focus on novel techniques to combat global blood shortage

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Potential mosquito-based malaria vaccine could be a step closer

CQDM, OCE grant $1.5M to speed up drug discovery and development in Quebec-Ontario Life Sciences Corridor

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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