Immune Response News and Research

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Researchers use SARS-CoV-2 to bioengineer universal vaccine platform

Using SARS-CoV-2, a team of scientists from the United States has recently developed a bioengineered bacteriophage T4 nanoparticle structure using CRISPR technology that can be used as a universal platform to produce vaccines.

21 Jan 2021

Researchers discover important cause of preeclampsia

Despite being the subject of increasing interest for a whole century, how preeclampsia develops has been unclear - until now.

21 Jan 2021

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization

A new study published shows that low levels of vitamin D are associated with a higher risk of COVID-19 hospitalization.

21 Jan 2021

High factor V levels linked to lymphopenia and weakened immunity in severe COVID-19

A new study suggests that factor V, a coagulation factor, is upregulated in a range of white blood cells in severe COVID-19. This increase is linked to the observed coagulopathy, lymphopenia and suppression of adaptive immunity in such patients.

21 Jan 2021

Eliminating key gene could revive exhausted immune cells to battle solid tumors

Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests.

20 Jan 2021

Can metabolic biomarkers help clinicians stratify adverse outcome risk in COVID-19 patients?

A recent study describes the alterations in lipids and other parameters that define the state of dysfunctional metabolism in acute COVID-19 illness.

20 Jan 2021

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Researchers develop a novel, simple and affordable method for N-glycan fingerprinting based on enzymatic fluorescent glycan labeling and electrophoresis. This new method may help us understand important changes in glycosylation in the SARS-CoV-2 spike protein – something which could inform future therapeutic research.

20 Jan 2021

Fecal microbiome and metabolome vary in healthy and food-allergic twins, shows study

A new study out of the University of Chicago and Stanford University on pairs of twins with and without food allergies has identified potential microbial players in this condition.

19 Jan 2021

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

In an exciting, state-of-the-art study currently available on the medRxiv* preprint server, US researchers created a multi-coronavirus protein microarray containing full-length proteins, peptide libraries, and overlapping protein fragments from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as four other human coronaviruses.

19 Jan 2021

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

A new study shows that the memory B cell response to SARS-Cov-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence.

19 Jan 2021

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

A new study by US-based researchers describes the results of a study on the immune response among healthcare workers, in particular, their T cell responses predating the pandemic.

19 Jan 2021

Prolonged shedding and multiple mutations 154 days after initial SARS-CoV-2 diagnosis reported

An interesting new preprint published on the medRxiv server describes an immunosuppressed patient with coronavirus disease 2019 (COVID-19) who continued to shed the virus for an astounding 154 days. During this period, the virus underwent numerous mutations.

19 Jan 2021

Australian scientists develop a new method for rapid synthesis of safe vaccines

With COVID-19 dominating medical science and human concern, our chemists have developed a method to quickly and safely synthesize protein vaccines for respiratory diseases for pre-clinical tests.

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

NK and T cell subsets show distinctive lung-homing receptor profiles in COVID-19 patients

A new study reveals in detail the changes that occur in peripheral blood natural killer (NK) and T cells in COVID-19.

18 Jan 2021

New SARS-CoV-2 variant emerges in the U.S.

Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the bioRxiv server describes a new American variant that may have become the dominant strain in the USA.

18 Jan 2021

Study sheds light on the causes of debilitating gut pain

A new study, published in the journal Nature, reports evidence from mice and humans that a novel mechanism contributes to chronic gut pain.

17 Jan 2021

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

There have been significant efforts worldwide to combat COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One prominent strategy has been to develop vaccines against the virus. Numerous vaccine candidates are under development, and a handful have now been approved for use by several countries.

17 Jan 2021

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals.

17 Jan 2021

National consortium to study the effects of emerging SARS-CoV-2 mutations

A new national research project to study the effects of emerging mutations in SARS-CoV-2 will be launched with £2.5 million of funding from UK Research and Innovation.

15 Jan 2021

Immune Response News and Research

Researchers use SARS-CoV-2 to bioengineer universal vaccine platform

Researchers discover important cause of preeclampsia

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization

High factor V levels linked to lymphopenia and weakened immunity in severe COVID-19

Eliminating key gene could revive exhausted immune cells to battle solid tumors

Can metabolic biomarkers help clinicians stratify adverse outcome risk in COVID-19 patients?

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Fecal microbiome and metabolome vary in healthy and food-allergic twins, shows study

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

Prolonged shedding and multiple mutations 154 days after initial SARS-CoV-2 diagnosis reported

Australian scientists develop a new method for rapid synthesis of safe vaccines

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

NK and T cell subsets show distinctive lung-homing receptor profiles in COVID-19 patients

New SARS-CoV-2 variant emerges in the U.S.

Study sheds light on the causes of debilitating gut pain

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

National consortium to study the effects of emerging SARS-CoV-2 mutations

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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