Mouse Model News and Research

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Researchers clarify alphaB-crystallin's role in multiple sclerosis

A protein found primarily in the lens of the eye could be the critical "tipping point" in the spiral of inflammation and damage that occurs in multiple sclerosis, researchers at the Stanford University School of Medicine report.

18 Jun 2007

Isradipine may slow Parkinson's

Gloria E. Meredith, Ph.D., collaborated with D. James Surmeier, Ph.D. and other scientists at Northwestern University to study the drug, Isradipine, and its possible effects on Parkinson's disease.

17 Jun 2007

Deleting gene important in embryo development leads to premature aging in mice

Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice.

8 Jun 2007

New platform for regulating the expression of therapeutic genes

A new platform for regulating the expression of therapeutic genes, which will have major implications for gene and cell therapy, was presented at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.

3 Jun 2007

New strategy for treating rare muscle disease, kidney disorders

Based on clues provided by a study with transgenic mice, a research group at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), has developed a strategy that will be tested as the first treatment for people with hereditary inclusion body myopathy (HIBM), a rare, degenerative muscle disease.

3 Jun 2007

Fat protein cuts blood vessel inflammation, may help heart

A natural substance secreted by fat cells can protect blood vessels from the damaging effects of inflammation, one of the factors that contribute to heart disease.

3 Jun 2007

Human antibodies protect mice from H5N1 avian influenza

An international team of scientists, including researchers from the National Institute of Allergy and Infectious Diseases (NIAID), report using antibodies derived from immune cells from recent human survivors of H5N1 avian influenza to successfully treat H5N1-infected mice as well as protect them from an otherwise lethal dose of the virus.

30 May 2007

Significant breakthrough in the search for an effective malaria vaccine

One person dies of it every 30 seconds, it rivals HIV and tuberculosis as the world's most deadly infection and the vast majority of its victims are under five years old.

28 May 2007

Scientists develop a more human-like mouse model of cancer

A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

28 May 2007

Study challenges conventional wisdom about cancer cells

A team of St. Jude investigators challenged conventional wisdom about the eye cancer retinoblastoma by using a mouse model that allowed them to study the tumors as they develop and grow.

27 May 2007

Significant breakthrough in the search for an effective malaria vaccine

One person dies of it every 30 seconds, it rivals HIV and tuberculosis as the world's most deadly infection and the vast majority of its victims are under five years old.

24 May 2007

Groundbreaking research on type 1 congenital myotonic dystrophy

Each year, the parents of an estimated one in 20,000 newborns are shocked to learn their child has type 1 congenital myotonic dystrophy (CDM1), a progressive and crippling genetic disorder.

24 May 2007

Novel preclinical gene therapy approach for treating Niemann-Pick disease

Genzyme Corp. has announced the publication of a new study in The Proceedings of the National Academy of Sciences describing a novel preclinical gene therapy approach for treating Niemann-Pick disease.

24 May 2007

Brca2 gene prevents medulloblastoma

Investigators at St. Jude Children's Research Hospital have gained some of the first major insights into how certain genes known to prevent cancer also guide the normal development of the nervous system before birth and during infancy by repairing DNA damage.

22 May 2007

Mammals have the power to regenerate

Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos.

18 May 2007

Antibody-based therapies effective at controlling malaria

Passive immunization through the development of fully human antibodies specific to Plasmodium falciparum may be effective at controlling the disease, report researchers led by Dr. Richard S.

18 May 2007

AMDL receives Israeli patent for animal model for the evaluation of vaccines

AMDL, Inc. has announced that it has received an important Israeli patent for an animal model for the evaluation of vaccines, which is a part of its unique Combination Immune Therapy (CIT) technology.

18 May 2007

Oncolytic viruses deliver a knockout punch to cancers

New scientific evidence is helping to build a compelling case for oncolytic viruses as a first-line and adjunctive treatment for many cancers.

11 May 2007

Molecule that destroys bone also protects it

An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.

7 May 2007

Reducing levels of the protein tau can prevent seizures and neurological deficits related to Alzheimer's disease

The findings, reported in the journal Science, demonstrate that when tau is removed from mice genetically engineered to simulate Alzheimer's disease, their memory function is retained and they live a normal lifespan. Reducing tau levels also made mice more resistant to epileptic seizures.

4 May 2007