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Chronic inflammation and poverty join forces to increase mortality risk

Chronic inflammation and poverty join forces to increase mortality risk

A new study led by a University of Florida College of Public Health and Health Professions researcher finds that people with chronic inflammation living in poverty have more than double the risk of dying from heart disease and nearly triple the risk of dying from cancer within the next 15 years.

16 Jan 2024

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

New Omicron variants relearn immunity dodging tricks

New Omicron variants relearn immunity dodging tricks

Recent SARS-CoV-2 variants such as BA.4 and BA.5 developed abilities missing from the first Omicron variants that allowed them to overcome humans' innate immunity, according to research from UCL.

16 Jan 2024

Conscience's open science competition yields hits for new Parkinson's drugs

Conscience's open science competition yields hits for new Parkinson's drugs

As part of its pioneering approach to drug discovery, the Canadian nonprofit Conscience announced today that its first open science competition has resulted in the identification of seven promising molecules, or "hits," that show potential for new, more effective drugs for familial Parkinson's disease.

16 Jan 2024

Study shows slight increase in Guillain-Barre syndrome risk with adenovirus COVID vaccines

Study shows slight increase in Guillain-Barre syndrome risk with adenovirus COVID vaccines

Study investigates the link between COVID-19 vaccines and autoimmune/neurological diseases, focusing on Guillain-Barre syndrome (GBS) risks associated with adenovirus vector vaccines.

16 Jan 2024

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

In the US, approximately 37.9 million people, or 11.4% of the population, lived below the poverty line in 2022.

16 Jan 2024

Jena researchers unravel PAPAS RNA's impact on breast cancer growth and metastasis

Jena researchers unravel PAPAS RNA's impact on breast cancer growth and metastasis

Breast cancer is the most common cancer in women. The development of breast cancer often originates from epithelial cells in the mammary gland – the very cells that specialise in milk production during and after pregnancy.

16 Jan 2024

Breakthrough nano-shield blocks selective allergic reactions

Breakthrough nano-shield blocks selective allergic reactions

Northwestern University researchers have developed the first selective therapy to prevent allergic reactions, which can range in severity from itchy hives and watery eyes to trouble breathing and even death.

16 Jan 2024

Research uncovers cells-of-origin for breast cancer in BRCA2 mutation carriers

Research uncovers cells-of-origin for breast cancer in BRCA2 mutation carriers

Australian scientists have pinpointed likely 'cells-of-origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease.

16 Jan 2024

Urea-powered nanorobots reduce bladder tumors by 90% in mice

Urea-powered nanorobots reduce bladder tumors by 90% in mice

The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumour, attacking it with a radioisotope carried on their surface.

16 Jan 2024

Amsterdam UMC project aims for first effective HIV vaccine with Gates funding

Amsterdam UMC project aims for first effective HIV vaccine with Gates funding

Worldwide, an estimated, 40 million people live with HIV. Two-thirds of this group on the African continent.

16 Jan 2024

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme.

16 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

International research collaboration leads to breakthrough in antibiotic resistance testing using DNA sequencing

International research collaboration leads to breakthrough in antibiotic resistance testing using DNA sequencing

The accuracy of antibiotic resistance determination from Enterococcus faecium genomes for diagnostic purposes.

15 Jan 2024

JN.1 variant's spread not due to enhanced immune escape, study suggests

JN.1 variant's spread not due to enhanced immune escape, study suggests

Study finds the JN.1 variant of SARS-CoV-2 may not have increased immune escape ability compared to its predecessor BA.2.86, suggesting other factors for its rapid spread.

14 Jan 2024

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Researchers develop a novel plasma proteome-based test for early detection of multiple cancers, achieving high accuracy in identifying low-abundance protein biomarkers.

14 Jan 2024

Study explores intratumoral microbiota as a novel frontier in cancer research

Study explores intratumoral microbiota as a novel frontier in cancer research

Researchers review the role of intratumoral microbiota in cancer development, suggesting its potential in predicting and treating various cancers.

14 Jan 2024

Study links stress to metabolic syndrome, highlights inflammation's role

Study links stress to metabolic syndrome, highlights inflammation's role

New research links stress to metabolic syndrome through inflammation, suggesting stress management as a potential strategy for improving biological health outcomes.

13 Jan 2024

RBM5 identified as key regulator of HOXA9 in acute myeloid leukemia

RBM5 identified as key regulator of HOXA9 in acute myeloid leukemia

The protein HOXA9 is overexpressed in most acute myeloid leukemia (AML) cases and is associated with poor patient outcomes.

12 Jan 2024

Defective gene triggers uncontrolled immune attack in young lupus patients

Defective gene triggers uncontrolled immune attack in young lupus patients

A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.

12 Jan 2024

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