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Nanofluidic biopsy detects subtle changes in cancer cells

By taking two standard laboratory techniques - capillary electrophoresis and antibody-based protein detection - and shrinking them to the nanoscale, researchers at the Stanford University School of Medicine have created a new method for detecting miniscule changes in the levels of proteins associated with cancer.

28 Jun 2009

Harnessing nanoparticles to track cancer cell changes

The more dots there are, the more accurate a picture you get when you connect them. Cancer researchers adopting that philosophy have developed a new imaging technology that could give scientists the ability to simultaneously measure as many as 100 or more distinct features in or on a single cell. In a disease such as cancer, that capability would provide a much better picture of what is going on in individual tumor cells.

28 Jun 2009

Early detection of pancreatic cancer closer thanks to multifunctional nanoparticles

Pancreatic cancer has a devastatingly low survival rate (less than 5 percent after 5 years) because it is usually diagnosed at an advanced stage. The initial symptoms, such as pain, jaundice, or weight loss, often do not allow the disease to be caught early enough for surgery and chemotherapy to be effective.

28 Jun 2009

Computer-guided nanoparticle therapy destroys tumors

Gold nanoshells are among the most promising new nanoscale therapeutics being developed to kill tumors, acting as antennas that turn light energy into heat that cooks cancer to death. Now, a multi-institutional research team has shown that polymer-coated gold nanorods one-up their spherical counterparts, with a single dose completely destroying all tumors in a nonhuman animal model of human cancer.

28 Jun 2009

Electrothermally driven micropumps for medicine

In biomedicine and biotechnology the smallest, complex, compound sample quantities must be reliably processed. Microsystems with new mechanisms of action for pumping, filtering and separating will manage this task with great efficiency in the future.

25 Jun 2009

IRIN examines PEPFAR funding of IDU programs

IRIN examines a recent comment piece in the journal Lancet that argues PEPFAR can do more to prevent the spread of HIV among injecting drug users (IDUs) in Africa (IRIN, 6/24).

24 Jun 2009

Scientists block Ebola infection in cell-culture experiments - could lead to first therapy

Researchers at the University of Texas Medical Branch at Galveston have discovered two biochemical pathways that the Ebola virus relies on to infect cells.

23 Jun 2009

New biomarker predicts brain tumor's response to cediranib therapy

A report in Cancer Research, a journal of the American Association for Cancer Research, highlights a new biomarker that may be useful in identifying patients with recurrent glioblastoma, or brain tumors, who would respond better to anti-vascular endothelial growth factor therapy, specifically cediranib.

23 Jun 2009

Diet and exercise to alleviate treatments for prostate cancer

A DVD, developed by academics at the University of Hertfordshire, which illustrates the positive effects of diet and exercise in the treatment of prostate cancer, will be launched tomorrow.

23 Jun 2009

New therapy found to prevent heart failure

A landmark study has successfully demonstrated a 29 percent reduction in heart failure or death in patients with heart disease who received an implanted cardiac resynchronization therapy device with defibrillator (CRT-D) versus patients who received only an implanted cardiac defibrillator (ICD-only).

23 Jun 2009

Jigsaw puzzle therapy for Alzheimer’s sufferers

A Kingston University design student has turned his coursework into a budding business venture, launching a jigsaw puzzle ideal for people living with dementia.

23 Jun 2009

Discovery of potent metastasis inhibitor

Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment.

23 Jun 2009

Music therapy for heart and stroke patients

Blood flow and respiratory rates can synch with music, indicating that music could one day be a therapeutic tool for blood pressure control and rehabilitation, according to a study by Italian researchers published in Circulation: Journal of the American Heart Association.

23 Jun 2009

New perspective on the causes, effects and potential treatment of sexual dysfunction

Couples' treatment for sexual problems and other innovative approaches to improving sexual health for men and women are on the agenda of sexual medicine experts.

23 Jun 2009

Parents struggle with costs of their children's autism care

The total cost for treating a child with autism can reach $5 million, but insurance companies rarely cover autism therapy and few states mandate it. CBS News reports that "an estimated one in every 150 children in America has autism and the number of reported cases is growing" while "parents are increasingly demanding that insurance companies cover the newest treatment."

22 Jun 2009

Big disparities in the treatment of arrhythmias across Europe

The latest statistics regarding the use of pacemakers and implantable cardiac devices in Europe was presented on Sunday 21 June, at EUROPACE 2009, the meeting of the European Heart Rhythm Association (EHRA) which takes place in Berlin, Germany from 21 to 24 June.

22 Jun 2009

PEPFAR and IDUs; economic crisis and health; human-rights and pharmaceutical companies

Although PEPFAR has helped to provide "antiretroviral therapy to 2.1 million people with HIV, almost all of whom live in sub-Saharan Africa, and has spent more than US$18 billion on the continent" it has failed to reach "thousands of injecting drug users in PEPFAR countries in Africa, many of whom have HIV," according to the authors of a recent comment in the journal Lancet.

21 Jun 2009

Targeting tumor behavior may find new anti-cancer agents

Ohio State University cancer researchers have used computational and genomic methods to identify possible anti-cancer agents that may block a particular kind of tumor behavior. The agents target multiple genes associated with that behavior at one time.

18 Jun 2009

Scientists edit genes in human stem cells

Researchers at the Johns Hopkins School of Medicine have successfully edited the genome of human- induced pluripotent stem cells, making possible the future development of patient-specific stem cell therapies. Reporting this week in Cell Stem Cell, the team altered a gene responsible for causing the rare blood disease paroxysmal nocturnal hemoglobinuria, or PNH, establishing for the first time a useful system to learn more about the disease.

18 Jun 2009

Increased risk of stroke and transient ischemic attack in survivors of Hodgkin lymphoma

Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke, according to a new study published June 17 online in the Journal of the National Cancer Institute.

17 Jun 2009