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Study identifies large number of undiagnosed patients likely infected with hepatitis C in Sweden

Using a large transfusion database, with data going back to the 1960s, researchers at Karolinska Institutet have been able to identify 44 donors and 1,180 transfused patients likely to be infected with hepatitis C, who are still alive and who remain undiagnosed.

24 Jul 2020

Study estimates the past and present burden of viral hepatitis through blood transfusions

What is the incidence of viral hepatitis caused by blood transfusions before and after Sweden introduced screening of blood in the early 1990s? In an article published in Eurosurveillance ahead of World Hepatitis Day on 28 July, the authors also try to estimate how many people of those who were infected with hepatitis B and C through blood transfusion still live with undiagnosed hepatitis.

23 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

Gene in fat cells plays a key role in regulating insulin sensitivity

Deleting a key gene in mice in just their fat made tissues throughout these animals insulin resistant, in addition to other effects, a new study by UT Southwestern researchers shows.

23 Jul 2020

Non-invasive algorithm predicts complications in patients following recovery from hepatitis C

The chronic viral inflammation of the liver that occurs in hepatitis C results in the formation of inflexible scar tissue in the form of fibrosis/cirrhosis of the liver. This impedes the flow of blood through the organ, with resulting hypertension in the portal vein.

23 Jul 2020

Buckwheat-based diet improves SIRT1 protein that helps enhance longevity

A healthy low-calorie diet that contains plant products can help us improve the level of sirtuin 1 (SIRT1) protein production that is known to increase life expectancy.

22 Jul 2020

Scientific evidence shows GLDH is a safe biomarker for drug-induced liver injury

Critical Path Institute (C-Path) announced today that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) from the U.S. Food and Drug Administration (FDA) issued a positive response to the Qualification Plan (QP) for glutamate dehydrogenase (GLDH) as a safety biomarker for drug-induced liver injury (DILI), developed by C-Path's Predictive Safety Testing Consortium (PSTC) and Duchenne Regulatory Science Consortium (D-RSC).

22 Jul 2020

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Now, a new study published on the preprint server bioRxiv in July 2020 presents an engineered transgenic mouse that reproduces the functional and clinical characteristics of severe human SARS-CoV-2 infection.

21 Jul 2020

Stanford researchers develop a portable device for rapidly detecting blood ammonia levels

Seated around the dinner table, faculty affiliated with Stanford ChEM-H - one of Stanford University's interdisciplinary institutes - spoke one-by-one, pitching ideas for collaborative research.

21 Jul 2020

Early detection of cancer four years before conventional diagnosis using non-invasive blood test

An international team of researchers has developed a non-invasive blood test that can detect whether an individual has one of five common types of cancers, four years before the condition can be diagnosed with current methods. The test detects stomach, esophageal, colorectal, lung and liver cancer.

21 Jul 2020

Cyanobacterial blooms in Florida waters release multiple toxins detrimental to human health

In 2018, cyanobacteria from nutrient-rich waters in Lake Okeechobee were released down the Caloosahatchee river at the same time that red tides were gathering along the Florida west coast, potentially exposing coastal residents to a mixture of toxins.

20 Jul 2020

Experimental therapy slows zika replication and prevents microcephaly in mice

An international group of researchers have discovered that inhibiting AHR (aryl hydrocarbon receptor), a protein with roles in regulating immunity, stem cell maintenance and cellular differentiation, enables the immune system to combat replication of zika virus in the organism far more effectively.

20 Jul 2020

Current choline intake levels are too low for most Americans, say health and nutrition experts

On Wednesday, July 15, 2020, the Dietary Guidelines Advisory Committee (DGAC or Committee) - a group comprised of 20 nationally recognized health and nutrition experts - published the Scientific Report of the 2020 Dietary Guidelines Advisory Committee: Advisory Report to the Secretary of Agriculture and the Secretary of Health and Human Services.

20 Jul 2020

Pesticide use can speed the transmission of schistosomiasis

Widespread use of pesticides and other agrochemicals can speed the transmission of the debilitating disease schistosomiasis, while also upsetting the ecological balances in aquatic environments that prevent infections, finds a new study led by researchers at the University of California, Berkeley.

17 Jul 2020

Common antioxidant enzyme catalase as COVID-19 treatment

A new paper by researchers from the USA and China and published on the preprint server bioRxiv in July 2020 discusses a new drug based on the catalase enzyme, which could play a vital part in reducing the inflammation associated with progressive and severe COVID-19 disease.

17 Jul 2020

Study could accelerate drug development to reduce age-related diseases

Genes linked to ageing that could help explain why some people age at different rates to others have been identified by scientists.

16 Jul 2020

Study identifies factors associated with death in critically ill COVID-19 patients

More than 3 million people in the United States have been infected with COVID-19 and more than 130,000 have died. More people have died of COVID-19 in the U.S. than in any other country, but few studies offer national data on the factors that may contribute to outcomes for critically ill patients.

15 Jul 2020

Human lungs rejected for transplant can be recovered using cross-circulation with pigs

A new experiment by researchers at the Columbia Engineering and Vanderbilt University may have the solution to this long-standing problem. The team revived and repaired the damaged lungs by cross-circulation support of the whole lungs outside the body using the circulatory system with that of a living pig.

14 Jul 2020

One in three young adults at a higher risk of severe COVID-19 due to smoking, vaping

Now, a new study shows that about one in three young adults may be at risk of severe COVID-19 due to smoking and vaping habits.

14 Jul 2020

Dual inhibitor therapy may be safer for CLL patients, Moffitt study shows

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. One in four new leukemia cases are CLL.

14 Jul 2020

Liver News and Research

Study identifies large number of undiagnosed patients likely infected with hepatitis C in Sweden

Study estimates the past and present burden of viral hepatitis through blood transfusions

Epigenomic modifications play key role in the development of lung tumors

Gene in fat cells plays a key role in regulating insulin sensitivity

Non-invasive algorithm predicts complications in patients following recovery from hepatitis C

Buckwheat-based diet improves SIRT1 protein that helps enhance longevity

Scientific evidence shows GLDH is a safe biomarker for drug-induced liver injury

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Stanford researchers develop a portable device for rapidly detecting blood ammonia levels

Early detection of cancer four years before conventional diagnosis using non-invasive blood test

Cyanobacterial blooms in Florida waters release multiple toxins detrimental to human health

Experimental therapy slows zika replication and prevents microcephaly in mice

Current choline intake levels are too low for most Americans, say health and nutrition experts

Pesticide use can speed the transmission of schistosomiasis

Common antioxidant enzyme catalase as COVID-19 treatment

Study could accelerate drug development to reduce age-related diseases

Study identifies factors associated with death in critically ill COVID-19 patients

Human lungs rejected for transplant can be recovered using cross-circulation with pigs

One in three young adults at a higher risk of severe COVID-19 due to smoking, vaping

Dual inhibitor therapy may be safer for CLL patients, Moffitt study shows

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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