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Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

Magnitude and durability of SARS-CoV-2 S-binding antibody titers in the pre-variant era among healthcare workers in NYC

Researchers analyzed sera samples of 400 participants of the PARIS study to evaluate the risk of SARS-CoV-2 infection and seroreversion for an average of 84 days.

4 Apr 2022

Study investigates targeted phenotyping of host proteins aiding drug repurposing in COVID-19

Researchers conducted selective phenotyping of coronavirus disease 2019 -relevant host proteins to facilitate target identification for drug repurposing.

4 Apr 2022

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

A recent study presented the rapid spike in COVID-19 seroprevalence during the emergence of the Omicron variant in Finland.

4 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

In a recent study published in the journal Science, researchers observed differential effector functions of antibodies elicited by Pfizer’s BNT162b2 and Moderna’s messenger ribonucleic acid (mRNA)-1273 coronavirus disease 2019 (COVID-19) vaccines.

4 Apr 2022

Customized digital alert improves guideline-directed medical therapy for heart failure

Physicians prescribed significantly more guideline-directed medications for heart failure if they received a customized digital alert via an electronic health record (EHR) system when inputting medical orders shortly after seeing a patient, according to a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Patiromer lowers hyperkalemia risk in heart failure patients taking RAASi therapy

Patients taking renin-angiotensin-aldosterone system inhibitor (RAASi) medications for heart failure had significantly lower blood potassium levels when taking patiromer—a drug that helps to prevent the body from absorbing too much potassium—compared with a placebo, in a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

The effect of COVID-19 on the lung function of young adults

Researchers evaluate whether SARS-CoV-2 infection has a negative impact on lung function in young adults who experienced mild to moderate COVID-19.

3 Apr 2022

TLR7 and MARK1 genomic variants impact COVID-19 prognosis

Researchers conduct a massive exome-wide genome study to explore the connections between gene variants/deleterious mutations and COVID-19 outcomes.

3 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Researchers developed a novel high-throughput method to obtain monoclonal antibodies from COVID-19 individuals infected with SARS-CoV-2 ancestral strain Wuhan-Hu-1 and the Beta or Gamma variants.

1 Apr 2022

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

The work investigated why the children experienced milder COVID-19 illness even after a strong immune response.

1 Apr 2022

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Researchers examined the role of sialic acid-binding immunoglobulin-type lectins-1, a myeloid cell-specific receptor, in facilitating SARS-CoV-2 infection of ACE2-deficient macrophages and its effect on pro-inflammatory cytokine expression.

1 Apr 2022

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

A team of international scientists has recently isolated and characterized pan-coronavirus neutralizing antibodies from individuals with pre-existing immunity against SARS-CoV-2.

1 Apr 2022

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

Zinc's immune-boosting properties are well-established, but scientists haven't known exactly how it works.

1 Apr 2022

No evidence of SARS-CoV-2 in the U.K.'s wild deer population

A new study accepted for publication in the journal Transboundary and Emerging Diseases assesses the potential exposure of U.K. deer to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since studies have shown the spill-over of SARS-CoV-2 infections to the Northern American white-tailed deer. If there is a spill-over, wild deer species can act as reservoirs of SARS-CoV-2 with the possibility of the emergence of new variants.

31 Mar 2022

Receptor News and Research

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

Magnitude and durability of SARS-CoV-2 S-binding antibody titers in the pre-variant era among healthcare workers in NYC

Study investigates targeted phenotyping of host proteins aiding drug repurposing in COVID-19

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

Customized digital alert improves guideline-directed medical therapy for heart failure

Patiromer lowers hyperkalemia risk in heart failure patients taking RAASi therapy

The effect of COVID-19 on the lung function of young adults

TLR7 and MARK1 genomic variants impact COVID-19 prognosis

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

No evidence of SARS-CoV-2 in the U.K.'s wild deer population

Therapeutic antibodies against filoviruses including Ebola and Marburg

The mucosal antibody response to SARS-CoV-2

The evolution of the SARS-CoV-2 spike protein

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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