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Microfluidic device mimics tumor microenvironment, helps drug discovery

One of the challenges that cancer researchers face in designing new antitumor agents is that of predicting how drug molecules will behave in the complex microenvironment that surrounds a tumor. In particular, tumors create all sorts of chemical and physical barriers that limit how much drug is able to enter a tumor, let alone reach cells deep within a tumor.

23 Feb 2009

Suppressing cancer with a master control gene

Starting with the tiny fruit fly and then moving into mice and humans, researchers at VIB and K. U. Leuven show that expression of the same gene suppresses cancer in all three organisms. Reciprocally, switching off the gene - called Ato in flies and ATOH1 in mammals - leads to cancer.

23 Feb 2009

Bavarian Nordic updates on breast cancer vaccine studies

Bavarian Nordic today provided updated data from its clinical studies with its breast cancer vaccine, MVA-BN(R)-HER2, in development as therapy of metastatic breast cancer patients whose tumours over-express HER2.

23 Feb 2009

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

Scientists have identified a small family of lab-made proteins that neutralize a broad range of influenza A viruses, including the H5N1 avian virus, the 1918 pandemic influenza virus and seasonal H1N1 flu viruses.

22 Feb 2009

Scientists identify human monoclonal antibodies effective against bird flu

Researchers at the Dana-Farber Cancer Institute (Dana-Farber), Burnham Institute for Medical Research (Burnham) and the Centers for Disease Control and Prevention (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range of influenza A viruses, including avian influenza A (H5N1) virus, previous pandemic influenza viruses, and some seasonal influenza viruses.

22 Feb 2009

Schering-Plough submits response to FDA for SAPHRIS (asenapine) in the acute treatment of schizophrenia and bipolar I disorder

Schering-Plough Corporation has announced that it has responded to the U.S. Food and Drug Administration (FDA) complete response letter for SAPHRIS (asenapine) sublingual tablets, which was received in January 2009.

22 Feb 2009

Laser treatment clinical trial misses primary endpoint

Using a laser to treat cells in the brain did not significantly reduce stroke disability, according to results of the first major clinical trial of laser therapy presented at the American Stroke Association's International Stroke Conference 2009.

22 Feb 2009

Gene therapy shows potential against HIV

A new UCLA AIDS Institute study has found that gene therapy can be developed as a safe and active technique to combat HIV.

22 Feb 2009

Scientists develop mobile sleep lab for home use

Poor sleep can be attributed to many causes, including shift work, stress, snoring or even sleep apnea - a disorder in which the sleeper temporarily stops breathing.

22 Feb 2009

Radioactive bone cement may be a new treatment option for breast cancer

For orthopaedic researcher Joyce Keyak, Ph.D., finding ways to battle breast cancer is a personal as well as a professional mission.

22 Feb 2009

Aching back? cholesterol drug Lovastatin might help

Back pain, a hallmark of degenerative disc disease, sends millions of people to their doctor. In fact, more than 80 percent of patients who undergo spine surgery do so because of disc degeneration.

22 Feb 2009

Stenting not necessary in late treatment of heart attacks

Two years ago, a major study found that many patients who receive delayed treatment for a heart attack do just as well with drugs alone as they do with drugs plus stents to prop open their blocked arteries.

20 Feb 2009

Robotic therapy may reduce stroke physical disability years later

Robot-assisted therapy may help stroke patients attain gains in their physical abilities long after the stroke, according to research presented at the American Stroke Association's International Stroke Conference 2009.

20 Feb 2009

Kidney disease affects response to anticoagulant drug warfarin

Patients with reduced kidney function require lower doses of the anticoagulant drug warfarin, and may need closer monitoring to avoid serious bleeding complications, suggests a study in the April 2009 issue of the Journal of the American Society of Nephrology ( JASN ).

20 Feb 2009

Back from the dead twice

“I died twice,” says a teary-eyed DeWayne Lark, “If I didn't believe in miracles before, I believe in them now.”

20 Feb 2009

FDA approves humanitarian device exemption for deep brain stimulator

The U.S. Food and Drug Administration has approved a humanitarian device exemption for the first implantable device that delivers intermittent electrical therapy deep within the brain to suppress the symptoms associated with severe obsessive-compulsive disorder (OCD).

20 Feb 2009

FDA issues warning on psoriasis drug Raptiva (efalizumab)

The U.S. Food and Drug Administration has issued a public health advisory concerning three confirmed, and one possible report of progressive multifocal leukoencephalopathy (PML), a rare brain infection, in patients using the psoriasis drug Raptiva (efalizumab).

20 Feb 2009

Optimizing dosage of blood-thinning drug warfarin

In a large-scale study and an upcoming clinical trial, scientists supported by the National Institutes of Health address one of the trickiest issues in prescribing medicine - how to quickly optimize each patient's dosage of the common blood-thinning drug warfarin.

20 Feb 2009

Cancer Research UK launches first super cancer centre in Birmingham

Birmingham will become the first link in a unique chain of Cancer Research UK Centres to be launched round the country.

20 Feb 2009

Blood pressure drug losartan may benefit brain tumor patients

A widely used blood pressure medication may be the key to preventing brain function loss common after radiation treatment, according to a newly published study by researchers at Wake Forest University Baptist Medical Center.

20 Feb 2009