Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Researchers develop method for purifying cardiac muscle cells using molecular beacons

Pure cardiac muscle cells, ready to transplant into a patient affected by heart disease. That's a goal for many cardiology researchers working with stem cells. Having a pure population of cardiac muscle cells is essential for avoiding tumor formation after transplantation, but has been technically challenging.

6 Sep 2013

Study: Death risk is greatest for those who developed hypertrophic cardiomyopathy in childhood

A long-term study of children with a complex heart condition called hypertrophic cardiomyopathy (HCM) found that the risk of death or need for immediate listing for heart transplantation was greatest for those who developed this disease as infants with congestive heart failure and for children who also had selective inborn errors of metabolism, a group of rare genetic disorders in which one or more of the body's key metabolic processes are disrupted.

5 Sep 2013

Biomarker strategy in suspected ACS patients has potential to change clinical practice

An emergency department strategy that uses two biomarkers to triage patients with suspected acute coronary syndrome (ACS) can increase the rate of early, safe hospital discharge, according to results of the Biomarkers in Cardiology 8 (BIC-8) trial.

5 Sep 2013

Anti-thrombotic therapy interruption has no influence on perioperative complications in cardiac patients

A shortened pre-surgical interruption of anti-thrombotic therapy, compared to the more traditional one-week interruption, has no influence on perioperative complications in cardiac patients, according to the results of the PRAGUE 14 trial.

5 Sep 2013

Multiple risk factors eliminate impact of AF on stroke risk, but more research is needed

Dr Benn Christiansen said: "We know that atrial fibrillation increases the risk of ischemic stroke. And in patients with atrial fibrillation or previous ischemic stroke, the risk of stroke increases with the number of risk factors.

5 Sep 2013

FIBRO-TARGETS project aims to identify mechanisms involved in MIF, define therapeutic approaches

Unravelling the mechanisms of cardiac fibrosis will lead to the discovery of therapeutic target candidates for various cardiac diseases. FIBRO-TARGETS brings together eleven European expert teams from six different countries both from public research institutes and European biotechs.

5 Sep 2013

Research findings raise hope for new heart therapies

Many people who survive a heart attack find themselves back in the hospital with a failing heart just years later. And the outcome often is unfavorable, owing to limited treatment options. But scientists at Temple University School of Medicine's Cardiovascular Research Center recently found hope in an unlikely source - stem cells in cortical, or compact, bone.

5 Sep 2013

Southampton researchers investigates influence of mechanical forces on cellular, molecular processes

University of Southampton researchers are at the forefront of research into mechanobiology, an emerging field of science combining biology and engineering, which investigates the influence of mechanical forces on cellular and molecular processes.

5 Sep 2013

US scientists identify risk factors for pediatric hypertrophic cardiomyopathy

US scientists have identified key risk factors that predict which children with hypertrophic cardiomyopathy, the most common cause of sudden death in young people, are at greatest risk of death or need for heart transplant—information that could help physicians figure out who will benefit most from transplant surgery.

4 Sep 2013

Researchers find way to resynchronize cardiac motion following heart attack

Mayo Clinic researchers have found a way to resynchronize cardiac motion following a heart attack using stem cells. Scientists implanted engineered stem cells, also known as induced pluripotent stem (iPS) cells, into damaged regions of mouse hearts following a heart attack.

4 Sep 2013

Researchers develop first animal model simulating eye complications linked with Graves' disease

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves' disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

3 Sep 2013

Omecamtiv mecarbil fails to achieve primary endpoint in phase II ATOMIC-AHF study

Omecamtiv mecarbil, a cardiac myosin-activator, did not achieve its primary efficacy endpoint in reducing dyspnoea (shortness of breath) in patients with acute heart failure, according to the results of the phase II ATOMIC-AHF (Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure) study.

3 Sep 2013

Study assesses relationship between BMI and CV events in hypertensive patients with diabetes

Low BMI is a risk factor for CVD in hypertensive patients with diabetes, according to research presented at the ESC Congress today by Dr Takanori Nagahiro from Japan. The findings provide evidence for an obesity paradox in hypertensive patients with glucose intolerance.

3 Sep 2013

Pacemakers implanted for slow heart rhythm restore life expectancy to normal levels

Pacemakers implanted for slow heart rhythm restore life expectancy to normal levels, reveals research presented at ESC Congress 2013 today by Dr Erik O. Udo from the Netherlands. The findings provide a new reference point for the prognosis of modern pacemaker patients.

2 Sep 2013

Despite living with highest risk factors for heart disease, people in high income countries suffer less

Despite living with the highest risk factors for heart disease, people in high income countries suffer less from serious cardiovascular disease, says an international study by the global PURE (Prospective Urban Rural Epidemiology ) collaboration and led by McMaster University researchers.

2 Sep 2013

University Of Virginia Gets $14.4M Grant To Fight Hypertrophic Cardiomyopathy

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28 Aug 2013

Respicardia reports successful implant of remede System for CSA patients

Respicardia, a developer of implantable therapies to improve respiratory and cardiovascular health, announced the successful implant of the first commercially-available remede system for patients with Central Sleep Apnea.

28 Aug 2013

Companion diagnostics: an interview with Trevor Hawkins, SVP, Strategy, Innovation and Business Development for Siemens Healthcare Diagnostics

Companion diagnostics is critical in helping to pave the way for personalized medicine, in which the treatment is adapted and precisely tailored to the patient.

From Siemens Healthineers 27 Aug 2013

FDA grants Priority Review designation to sNDA for Nexavar tablets

Bayer HealthCare and Onyx Pharmaceuticals today announced that the U.S. Food and Drug Administration has granted Priority Review designation to the supplemental New Drug Application for the oral multi-kinase inhibitor Nexavar (sorafenib) tablets under evaluation for the treatment of locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer.

27 Aug 2013

Challenges of studying health and mortality risks of obesity

Researchers from the Perelman School of Medicine point out that the body mass index, based on the weight and height, is not an accurate measure of body fat content and does not account for critical factors that contribute to health or mortality, such as fat distribution, proportion of muscle to fat, and the sex and racial differences in body composition.

23 Aug 2013

Heart Failure News and Research

Further Reading

Researchers develop method for purifying cardiac muscle cells using molecular beacons

Study: Death risk is greatest for those who developed hypertrophic cardiomyopathy in childhood

Biomarker strategy in suspected ACS patients has potential to change clinical practice

Anti-thrombotic therapy interruption has no influence on perioperative complications in cardiac patients

Multiple risk factors eliminate impact of AF on stroke risk, but more research is needed

FIBRO-TARGETS project aims to identify mechanisms involved in MIF, define therapeutic approaches

Research findings raise hope for new heart therapies

Southampton researchers investigates influence of mechanical forces on cellular, molecular processes

US scientists identify risk factors for pediatric hypertrophic cardiomyopathy

Researchers find way to resynchronize cardiac motion following heart attack

Researchers develop first animal model simulating eye complications linked with Graves' disease

Omecamtiv mecarbil fails to achieve primary endpoint in phase II ATOMIC-AHF study

Study assesses relationship between BMI and CV events in hypertensive patients with diabetes

Pacemakers implanted for slow heart rhythm restore life expectancy to normal levels

Despite living with highest risk factors for heart disease, people in high income countries suffer less

University Of Virginia Gets $14.4M Grant To Fight Hypertrophic Cardiomyopathy

Respicardia reports successful implant of remede System for CSA patients

Companion diagnostics: an interview with Trevor Hawkins, SVP, Strategy, Innovation and Business Development for Siemens Healthcare Diagnostics

FDA grants Priority Review designation to sNDA for Nexavar tablets

Challenges of studying health and mortality risks of obesity

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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