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Researchers show biophysical factors that contribute to the strength of heartbeat

The heart maintains a careful balancing act; too soft and it won't pump blood, but too hard and it will overtax itself and stop entirely. There is an optimal amount of strain that a beating heart can generate and still beat at its usual rate, once per second.

12 Dec 2013

Circulating nucleosomes and colorectal cancer diagnostics: an interview with Dr. Stefan Holdenrieder, University Hospital Bonn

For my MD thesis I modified and evaluated an immunological assay that detected the cell death products “nucleosomes” as a new blood-based cancer biomarker. As cell death processes are enhanced or suppressed during different stages of tumor development, it was assumed that they may enable stage-dependent detection of cancer disease.

12 Dec 2013

Combination therapy safe and active in follicular lymphoma

One drug attacks tumor cells directly, the other treats the immune system by taking the brakes off T cell response.

12 Dec 2013

Mitochondrial enzyme SIRT5 regulates proteins involved in metabolism

The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation.

12 Dec 2013

Study shows that age and sleep deprivation induce cellular stress in pancreas

Sleep, or the lack of it, seems to affect just about every aspect of human physiology. Yet, the molecular pathways through which sleep deprivation wreaks its detrimental effects on the body remain poorly understood.

12 Dec 2013

New reports demonstrate the effectiveness of modified T cells in treating blood-borne cancers

At the 2013 American Society of Hematology meeting in Dec. 2013, James Kochenderfer, M.D., investigator in the Experimental Transplantation and Immunology Branch, NCI, presented findings from two clinical trials evaluating the use of genetically modified immune system T cells as cancer therapy.

12 Dec 2013

New strategy for fighting infection targets patient's cells rather than invading pathogens

As more reports appear of a grim "post-antibiotic era" ushered in by the rise of drug-resistant bacteria, a new strategy for fighting infection is emerging that targets a patient's cells rather than those of the invading pathogens.

12 Dec 2013

IDIBELL researchers explain the regulator mechanisms of mitosis

Researchers at the Cell Cycle Research Group of the Bellvitge Institute of Biomedical Research (IDIBELL) led by Ethel Queralt have reported in the journal PLoS Genetics an article which delve into the regulator mechanisms of mitosis, a key stage of the cell-cycle for the correct transmision of genetic information from parents to sons.

12 Dec 2013

Late-breaking abstracts on treatment of blood cancers and bleeding disorders presented at ASH meeting

A range of studies highlighting late-breaking research advances in the understanding and treatment of blood cancers and bleeding disorders are being presented today during the 55th American Society of Hematology Annual Meeting and Exposition in New Orleans.

12 Dec 2013

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

Researchers from the Laboratory of Cancer Metabolism (LCM) led by George Thomas at the Bellvitge Biomedical Research Institute (IDIBELL), the Catalan Institute of Oncology (ICO) and the Division of Hematology/ Oncology, University of Cincinnati, have shown that loss of either one of two tumor suppressors, ribosomal proteins RPL5 or RPL11, fail to induce cell-cycle arrest, but prevent the proliferation of cells as they have a reduced capacity to synthesize proteins.

12 Dec 2013

Understanding long-term clinical stability in hemophilia patients living with HIV

People with the genetic blood clotting disorder hemophilia who have been infected with HIV for decades have an increased proportion of immune cells in their blood that specifically target HIV. This protective immune response helps chronically infected hemophilia patients survive, even during periods of HIV activity, according to a study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

12 Dec 2013

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

It is well known that type 2 diabetes raises the risk of dementia. The reasons for this are less clear, but one explanation could be insulin resistance in the brain, according to Malin Wennstr-m, a researcher at Lund University's Molecular Memory Research Unit. She has received EUR 700,000 from the Swedish Research Council to investigate her theory.

12 Dec 2013

Researchers refute avalanche theory on cancer

First, the number of chromosomes in a cell changes, then an avalanche of further mutations occur that transform the cell into a cancer cell, according to a well-known - but untested - theory.

12 Dec 2013

Immunocellular Therapeutics reports positive results from ICT-107 Phase II study in glioblastoma patients

ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") announced that ICT-107, its dendritic cell-based vaccine, demonstrated a statistically significant increase in progression-free survival (PFS) in patients with newly diagnosed glioblastoma multiforme (GBM) in its randomized, placebo-controlled phase II trial.

12 Dec 2013

Queen's University to lead €6 million European study to find new treatments for bowel cancer

Queen's University has announced it is to lead a -6 million European study to find new treatments for bowel cancer.

12 Dec 2013

New mechanism explains why anti-tumor activity of specific immune suppressed during tumor growth

The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth. They have also demonstrated that blocking the protein Nrp1 can restore this anti-tumor immune response.

12 Dec 2013

Scientists explore mechanisms of viruses' shells

Viruses are like small vessels containing an active component, the genetic material, that can infect a host cell. The vessel, called capsid or vector, is basically a shell that changes its shape when it penetrates a cell to infect it, and may even break into pieces.

12 Dec 2013

Tumor-infiltrating lymphocytes may be good biomarker of response to trastuzumab in breast cancer

Women with HER2-positive breast cancer who had the highest levels of immune cells in their tumors gained the most benefit from presurgery treatment with chemotherapy and trastuzumab, according to results presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.

12 Dec 2013

Probe mimics pathogen's amino acids, solving mystery behind Chlamydiae cell wall

Biochemical sleuthing by an Indiana University graduate student has ended a nearly 50-year-old search to find a megamolecule in bacterial cell walls commonly used as a target for antibiotics, but whose presence had never been identified in the bacterium responsible for the most commonly reported sexually transmitted disease in the United States.

12 Dec 2013

Elevated BACE1 activity in mild cognitive impairment could be early indicator of AD, says study

The critical enzyme beta-secretase1 (BACE1) is known to be elevated in brains with sporadic Alzheimer disease (AD). Scientists have now found increased levels of BACE1 in brains with mild cognitive impairment (MCI), suggesting that BACE1 activity is important for conversion of mild cognitive impairment to AD and may be an early indicator of AD.

12 Dec 2013

Cell News and Research

Researchers show biophysical factors that contribute to the strength of heartbeat

Circulating nucleosomes and colorectal cancer diagnostics: an interview with Dr. Stefan Holdenrieder, University Hospital Bonn

Combination therapy safe and active in follicular lymphoma

Mitochondrial enzyme SIRT5 regulates proteins involved in metabolism

Study shows that age and sleep deprivation induce cellular stress in pancreas

New reports demonstrate the effectiveness of modified T cells in treating blood-borne cancers

New strategy for fighting infection targets patient's cells rather than invading pathogens

IDIBELL researchers explain the regulator mechanisms of mitosis

Late-breaking abstracts on treatment of blood cancers and bleeding disorders presented at ASH meeting

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

Understanding long-term clinical stability in hemophilia patients living with HIV

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

Researchers refute avalanche theory on cancer

Immunocellular Therapeutics reports positive results from ICT-107 Phase II study in glioblastoma patients

Queen's University to lead €6 million European study to find new treatments for bowel cancer

New mechanism explains why anti-tumor activity of specific immune suppressed during tumor growth

Scientists explore mechanisms of viruses' shells

Tumor-infiltrating lymphocytes may be good biomarker of response to trastuzumab in breast cancer

Probe mimics pathogen's amino acids, solving mystery behind Chlamydiae cell wall

Elevated BACE1 activity in mild cognitive impairment could be early indicator of AD, says study

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