Antibiotic News and Research

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Antibiotics are drugs used to treat infections caused by bacteria and other microorganisms.

Study explores analgesic activity of ceftriaxone in humans

A single dose of the antibiotic ceftriaxone given for antimicrobial prophylaxis prior to surgery enhanced patient pain thresholds after the procedure, according to a study published in The Journal of Pain, the peer review publication of the American Pain Society.

26 Jun 2013

BioFire Diagnostics' FilmArray Blood Culture Identification Panel receives FDA clearance

BioFire Diagnostics, Inc., announced today the FDA clearance of its FilmArray Blood Culture Identification Panel. To date, the 27-target panel is the most comprehensive test to be approved by the FDA.

26 Jun 2013

Newly developed palm-sized microarray platform could enable faster, more efficient drug discovery

A new palm-sized microarray that holds 1,200 individual cultures of fungi or bacteria could enable faster, more efficient drug discovery, according to a study published in mBio-, the online open-access journal of the American Society for Microbiology.

25 Jun 2013

Mayo Clinic opens new C. difficile Clinic at Rochester campus

Clostridium difficile (C. difficile) has reached an epidemic state and is the most common infectious cause of diarrhea in hospitals. Health care providers are seeing increased severity and recurrence rates of the infection. In response, Mayo Clinic has opened a C. difficile Clinic at the Rochester campus.

25 Jun 2013

Rebiotix receives FDA Fast Track designation for RBX2660 to treat patients with CDI

Rebiotix Inc. announced today that the U.S. Food and Drug Administration has granted Fast Track designation for the investigation of RBX2660 (microbiota suspension), intended for the treatment of recurrent Clostridium difficile infection.

25 Jun 2013

Linagliptin significantly reduces blood glucose levels in T2D patients with moderate to severe renal impairment

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company today announced results from a new study in which linagliptin demonstrated statistically significant reductions in blood glucose levels (HbA1c) after 12 weeks (the study's primary endpoint) in adults with type 2 diabetes (T2D) with moderate to severe renal impairment, compared with placebo. Most patients had T2D for more than ten years (76 percent) and were on insulin (86 percent).

24 Jun 2013

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs. In addition, standard antibacterial drugs are proving increasingly ineffective in complete eradication, as Chlamydia goes in to persistent mode, leading to asymptomatic chronic infection.

21 Jun 2013

Scientists find way to attack dangerous bacteria that cause eye infections

Much as predators attack their prey in the animal world, there are bacteria that consume and kill other bacteria. Scientists are reporting new progress in putting the predator microbes to work - to attack dangerous bacteria that cause eye infections that lead to blindness and have grown resistant to antibiotics.

21 Jun 2013

Rigorous interventions result in fewer infections, deaths associated with hospital-onset C. difficile

Rhode Island Hospital has reduced the incidence of hospital-associated Clostridium difficile (C. difficile) infections by 70 percent and reduced annual associated mortality in patients with hospital-associated C. difficile by 64 percent through successive implementation of five rigorous interventions , as reported in the July 2013 issue of The Joint Commission Journal on Quality and Patient Safety.

21 Jun 2013

Microfluidic devices can trap and sort bacteria and viruses in food and water

A new process for making a three-dimensional microstructure that can be used in the analysis of cells could prove useful in counterterrorism measures and in water and food safety concerns.

20 Jun 2013

Treating bacteria with silver compounds boosts efficacy of old antibiotics

Slipping bacteria some silver could give old antibiotics new life, scientists at the Wyss Institute for Biologically Inspired Engineering at Harvard University reported June 19 in Science Translational Medicine.

20 Jun 2013

Staph-killing compound may be effective against osteomyelitis

Osteomyelitis - a debilitating bone infection most frequently caused by Staphylococcus aureus ("staph") bacteria - is particularly challenging to treat.

20 Jun 2013

Doctoral research shows role of immune system in development of resistance to antibiotics

Leon Cantas' doctoral research shows that the immune response of the host to a bacterial infection may have a significant effect on the development of bacteria's resistance to antibiotics.

19 Jun 2013

Scientists discover new anti-tuberculosis compound that kills drug-resistant TB bacteria

An international team led by scientists at The Scripps Research Institute (TSRI), the Howard Hughes Medical Institute and Albert Einstein College of Medicine of Yeshiva University has identified a highly promising new anti-tuberculosis compound that attacks the tuberculosis (TB) bacterium in two different ways.

18 Jun 2013

Antibiotic with clinical potential can stimulate own production, say scientists

An antibiotic has been found to stimulate its own production. The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.

18 Jun 2013

TSRI scientists identify highly promising new anti-tuberculosis compound

An international team led by scientists at The Scripps Research Institute, the Howard Hughes Medical Institute and Albert Einstein College of Medicine of Yeshiva University has identified a highly promising new anti-tuberculosis compound that attacks the tuberculosis bacterium in two different ways.

18 Jun 2013

Academies recommend ways to prevent antibiotic resistance, to develop antibiotics more quickly

Joint press release by the Academy of Sciences and Humanities in Hamburg and the German National Academy of Sciences Leopoldina

17 Jun 2013

Educating pediatricians on appropriate antibiotic usage can improve outcomes in children’s infections

As disease-causing microbes continue their worrisome trend of developing resistance to commonly used antibiotics, public health experts have called for more selective use of those medicines. A new study suggests that educating pediatricians in their offices, and auditing their prescription patterns, encourages them to choose more appropriate antibiotics for children with common respiratory infections.

14 Jun 2013

Study: Intervention improves adherence to prescribing guidelines for pediatric bacterial ARTIs

An intervention consisting of clinician education coupled with personalized audit and feedback about antibiotic prescribing improved adherence to prescribing guidelines for common pediatric bacterial acute respiratory tract infections, although the intervention did not affect antibiotic prescribing for viral infections, according to a study in the June 12 issue of JAMA.

14 Jun 2013

Study provides new insight into how pyrazinamide works

Pyrazinamide (PZA)-a frontline tuberculosis drug-kills dormant persister bacteria and plays a critical role in shortening TB therapy. PZA is used for treating both drug susceptible and multi-drug resistant TB but resistance to PZA occurs frequently and can compromise treatment.

14 Jun 2013

Antibiotic News and Research

Further Reading

Study explores analgesic activity of ceftriaxone in humans

BioFire Diagnostics' FilmArray Blood Culture Identification Panel receives FDA clearance

Newly developed palm-sized microarray platform could enable faster, more efficient drug discovery

Mayo Clinic opens new C. difficile Clinic at Rochester campus

Rebiotix receives FDA Fast Track designation for RBX2660 to treat patients with CDI

Linagliptin significantly reduces blood glucose levels in T2D patients with moderate to severe renal impairment

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Scientists find way to attack dangerous bacteria that cause eye infections

Rigorous interventions result in fewer infections, deaths associated with hospital-onset C. difficile

Microfluidic devices can trap and sort bacteria and viruses in food and water

Treating bacteria with silver compounds boosts efficacy of old antibiotics

Staph-killing compound may be effective against osteomyelitis

Doctoral research shows role of immune system in development of resistance to antibiotics

Scientists discover new anti-tuberculosis compound that kills drug-resistant TB bacteria

Antibiotic with clinical potential can stimulate own production, say scientists

TSRI scientists identify highly promising new anti-tuberculosis compound

Academies recommend ways to prevent antibiotic resistance, to develop antibiotics more quickly

Educating pediatricians on appropriate antibiotic usage can improve outcomes in children’s infections

Study: Intervention improves adherence to prescribing guidelines for pediatric bacterial ARTIs

Study provides new insight into how pyrazinamide works

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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