Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Genetic risk factor for West Nile virus infection identified

People who lack a cell surface protein called CCR5 are highly resistant to infection by HIV but may be at increased risk of developing West Nile virus (WNV) illness when exposed to the mosquito-borne virus, report researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

18 Jan 2006

Missing protein C/EBPb may be cause of infertility

The absence of a key protein may lead to infertility. Researchers at the University of Illinois at Urbana-Champaign report that experiments involving mice -- to be detailed in the Proceedings of the National Academy of Sciences -- indicate that the transcription factor protein C/EBPb must be present in the uterus for pregnancy to occur.

18 Jan 2006

Single gene may hold key to schizophrenia

By deleting a single gene in a small portion of the brains of mice, researchers at UT Southwestern Medical Center found that the animals were affected in a way resembling schizophrenia in humans.

18 Jan 2006

Identification of bipolar risk gene

A collaboration, led by scientists at the Garvan Institute of Medical Research and the University of New South Wales (UNSW) in Sydney, has discovered the first risk gene specifically for bipolar disorder, also known as manic-depressive illness. This means that people who have a particular form of this gene are twice as likely to develop the disease.

16 Jan 2006

Systemic spread of avian influenza virus in cats

Researchers at Erasmus Medical Center have demonstrated systemic spread of avian influenza virus in cats infected by respiratory, digestive, and cat-to-cat contact.

16 Jan 2006

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease.

16 Jan 2006

Discovery of protein fragment that helps predict breast cancer outcome

Oregon Health & Science University Cancer Institute researchers have identified a protein fragment in some human breast cancers that may help predict a patient's chances of survival.

16 Jan 2006

DinB DNA polymerase is a key player in DNA repair

A quarter century after they discovered it, researchers have identified the job of one of the most common DNA-damage response proteins. The enzyme has puzzled scientists because it is present in nearly every organism, which suggests that it is crucial to life, and yet, in laboratory experiments, its function has remained a mystery.

11 Jan 2006

Protein finding could lead to new topical treatment for inflammatory diseases

A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University of Illinois at Urbana-Champaign.

11 Jan 2006

Vaccine candidate for hepatitis C

Researchers at the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) have developed a vaccine candidate for hepatitis C, leading to hope in the fight against a disease for which no vaccines are yet available.

11 Jan 2006

Giant protein titin helps build muscles

Imagine grabbing two snakes by the tail so that they can't wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King's College in London have now discovered that something similar happens to a protein that is crucial in the formation of muscle tissue.

11 Jan 2006

Hedgehog protein plays a role in regulating fat and bone

A protein that guides the early development of creatures as diverse as fruit flies and humans also plays a role in regulating fat and bone formation in adult organisms, researchers at UT Southwestern Medical Center have discovered.

10 Jan 2006

Gene that increases risk for Alzheimer's disease

An international team of researchers, led by investigators at Washington University School of Medicine in St. Louis, are zeroing in on a gene that increases risk for Alzheimer's disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans.

10 Jan 2006

Evidence for impaired retroviral defense genes in humans

Researchers Harmit Malik and Michael Emerman and colleagues at the Fred Hutchinson Cancer Research Center have found that a surprisingly large fraction of humans may be impaired in the function of a recently discovered arm of the body's defense against invading retroviruses such as HIV.

10 Jan 2006

Detecting MRSA outbreaks

German researchers have proposed an automated DNA sequence-based early warning system to detect methicillin-resistant Staphylococcus aureus (MRSA) outbreaks in hospitals, which they say could replace traditional slower techniques.

10 Jan 2006

Diet rich in veggies lowers blood pressure

Researchers say that a diet rich in vegetables rather than meat can help to reduce blood pressure, and the more plant protein consumed the better.

10 Jan 2006

Value of prostate tests dubious

According to new research, men screened for prostate cancer using blood tests or digital examinations die of the disease at much the same rate as those who were not checked.

10 Jan 2006

Study finds short-term lifestyle changes improve health even without major weight loss

Obese and overweight individuals suffering metabolic syndrome and Type 2 diabetes showed significant health improvements after only three weeks of diet and moderate exercise even though the participants remained overweight.

10 Jan 2006

Human Genome Sciences announces license agreement with Amgen

Human Genome Sciences has announced a license agreement with Amgen under which Amgen has acquired exclusive worldwide rights to develop and commercialize therapeutic biological products for human use based on a human gene discovered by Human Genome Sciences that may have potential applications in autoimmune diseases, immune deficiencies or suppression, and cancer.

10 Jan 2006

Polyphosphate speeds blood clotting and helps clots last longer

A serendipitous comparison prompted by an old scientific image and involving an ancient but understudied molecule may lead to a new treatment strategy for injuries or illnesses in which blood clotting is paramount to survival.

9 Jan 2006