Huntington’s Disease News and Research

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MID1 complex binds with messenger RNA and controls synthesis of defective Huntingtin

Huntington's disease, also known as Huntington's chorea, is a hereditary brain disease causing movement disorders and dementia. In Germany, there are about 8,000 patients affected by Huntington's disease, with several hundred new cases arising every year. The disease usually manifests between the ages of 35 and 50.

27 Feb 2013

Symptoms poor guide to testing for juvenile Huntington disease

The onset or presentation of specific clinical features that are typical of juvenile Huntington’s Disease (JHD) do not help physicians to diagnose the condition without genetic testing.

25 Feb 2013

Targeting CSF1R with selective inhibitors could help Alzheimer's

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.

22 Feb 2013

TP PCR methodology may help streamline genetic testing for Huntington's

A new test may help to streamline genetic testing for Huntington Disease (HD) by generating accurate results, avoiding unnecessary additional testing, and improving turnaround time.

14 Feb 2013

Sangamo BioSciences fourth quarter revenues increase to $8.9 million

Sangamo BioSciences, Inc. today reported fourth quarter and full year 2012 financial results and accomplishments.

7 Feb 2013

Scientists receive honorary doctorate for research on Alzheimer's disease

On Monday 4 February, Dennis J. Selkoe and five other "brain teasers" will receive an honorary doctorate from the KU Leuven. The promoters for this honorary doctorate - VIB-KU Leuven professors Bart De Strooper and Wim Robberecht - will honor Dennis J. Selkoe for his scientific insights, but also for his relentless search for new medicines to treat Alzheimer's Disease and other conditions that cause severe damage in the brain.

4 Feb 2013

Researchers to develop new diagnostic tools and treatments for people with rare diseases

A multi-million Euro initiative is bringing together researchers from across the world to develop new diagnostic tools and new treatments for people with rare diseases and to connect research data in this area on a global scale.

25 Jan 2013

Repression of PTB protein in fibroblasts can convert pluripotent stem cells into functional neurons

Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells - abundantly found in connective tissues - into functional neurons. The findings, which could have far-reaching implications for the development of new treatments for neurodegenerative diseases like Huntington's, Parkinson's and Alzheimer's, will be published online in advance of the January 17 issue of the journal Cell.

11 Jan 2013

Discussing patients’ end-of-life wishes ‘key’ in Huntington’s

Discussing end-of-life issues with patients suffering from Huntington’s disease is a key responsibility for physicians, say Dutch researchers.

9 Jan 2013

Researchers develop new materials to support stem cell growth

Stem cell manufacturing for drug screening and treatments for diseases such as Huntington's and Parkinson's could be boosted by a new method of generating stem cells, a study suggests.

9 Jan 2013

Scientists wrestle to understand why Huntington's can produce variable symptoms

Scientists have wrestled to understand why Huntington's disease, which is caused by a single gene mutation, can produce such variable symptoms. An authoritative review by a group of leading experts summarizes the progress relating cell loss in the striatum and cerebral cortex to symptom profile in Huntington's disease, suggesting a possible direction for developing targeted therapies.

9 Jan 2013

Dementia diagnosis: an interview with Dr Andrew Blackwell, Chief Scientific Officer, Cambridge Cognition

Dementia is a huge public health problem, affecting about 800,000 people in the UK and 36 million people around the world.

8 Jan 2013

New technique can precisely add or delete genes in living cells

Researchers at MIT, the Broad Institute and Rockefeller University have developed a new technique for precisely altering the genomes of living cells by adding or deleting genes.

4 Jan 2013

Kareus announces start of KU-046 Phase I study in Alzheimer's

Kareus Therapeutics SA, the private biotechnology company focused on the development of novel therapeutics for the unmet treatment of age-related and chronic diseases, today announces the start of a Phase I clinical study following the Investigational New Drug (IND) approval from the US Food and Drug Administration for the development of KU-046, a first-in-class disease modifying new chemical entity discovered for the treatment of Alzheimer's disease using Kareus' proprietary bioenergetics and KARLECT platforms.

3 Jan 2013

Zucker Hillside Hospital celebrates opening of new $120 million inpatient pavilion

Zucker Hillside Hospital today celebrated the opening of a new 130,000-square-foot, $120 million inpatient pavilion. Constructed with the generous support of North Shore-LIJ Health System trustees Donald and Barbara Zucker and other donors, the 130,000-square-foot building will consolidate outdated living quarters dispersed across the psychiatric facility's campus, significantly improving the coordination of services and treatment along the continuum of care.

12 Dec 2012

Mass. Eye and Ear opens new outpatient surgical center in Longwood/Mission Hill

Massachusetts Eye and Ear, Longwood, a new outpatient surgical center at 800 Huntington Avenue in the Longwood/Mission Hill area of Boston, opened today to patients.

11 Dec 2012

JPND invites proposals from researchers to understand the underlying causes of neurodegenerative diseases

The EU Joint Programme - Neurodegenerative Disease Research (JPND) is inviting calls for proposals from research teams across Europe to increase understanding of the factors that put people at risk of developing neurodegenerative diseases (ND) such as Alzheimer's and also to evaluate health and social care strategies for people living with these debilitating illnesses.

10 Dec 2012

Dendritic spines respond to and process synaptic inputs both chemically and electrically

It's the least understood organ in the human body: the brain, a massive network of electrically excitable neurons, all communicating with one another via receptors on their tree-like dendrites. Somehow these cells work together to enable great feats of human learning and memory. But how?

6 Dec 2012

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease.

30 Nov 2012

New way to protect neurons that express mutant huntingtin proteins

By using a model, researchers at the University of Montreal have identified and "switched off" a chemical chain that causes neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis and dementia. The findings could one day be of particular therapeutic benefit to Huntington's disease patients. "We've identified a new way to protect neurons that express mutant huntingtin proteins," explained Dr. Alex Parker of the University of Montreal's Department of Pathology and Cell Biology and its affiliated CRCHUM Research Centre.

27 Nov 2012

Huntington’s Disease News and Research

MID1 complex binds with messenger RNA and controls synthesis of defective Huntingtin

Symptoms poor guide to testing for juvenile Huntington disease

Targeting CSF1R with selective inhibitors could help Alzheimer's

TP PCR methodology may help streamline genetic testing for Huntington's

Sangamo BioSciences fourth quarter revenues increase to $8.9 million

Scientists receive honorary doctorate for research on Alzheimer's disease

Researchers to develop new diagnostic tools and treatments for people with rare diseases

Repression of PTB protein in fibroblasts can convert pluripotent stem cells into functional neurons

Discussing patients’ end-of-life wishes ‘key’ in Huntington’s

Researchers develop new materials to support stem cell growth

Scientists wrestle to understand why Huntington's can produce variable symptoms

Dementia diagnosis: an interview with Dr Andrew Blackwell, Chief Scientific Officer, Cambridge Cognition

New technique can precisely add or delete genes in living cells

Kareus announces start of KU-046 Phase I study in Alzheimer's

Zucker Hillside Hospital celebrates opening of new $120 million inpatient pavilion

Mass. Eye and Ear opens new outpatient surgical center in Longwood/Mission Hill

JPND invites proposals from researchers to understand the underlying causes of neurodegenerative diseases

Dendritic spines respond to and process synaptic inputs both chemically and electrically

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

New way to protect neurons that express mutant huntingtin proteins

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