Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Researchers assess monkeypox clinical management guidelines worldwide

A new study demonstrated the scarcity of appropriate clinical management guidelines for monkeypox infections across the globe.

20 Jun 2022

The feasibility of sperm cryopreservation for male COVID-19 patients

In an article recently published in Frontiers in Endocrinology, scientists deciphered the possibility of cryopreserving sperm of coronavirus disease 2019 (COVID-19) patients

20 Jun 2022

Research may open door to the design of a better structured rabies vaccine

Rabies virus kills a shocking 59,000 people each year, many of them children. Some victims, especially kids, don't realize they've been exposed until it is too late.

17 Jun 2022

HIV coinfection significantly impacts B cell response to SARS-CoV-2

In recent research posted to the bioRxiv* preprint server, investigators confirmed that human immunodeficiency virus (HIV) co-infection alters B cell reaction in coronavirus disease 2019 (COVID-19).

17 Jun 2022

Type I interferons play crucial role in fending off SARS-CoV-2

Researchers investigated whether individuals with breakthrough infections of COVID-19 pneumonia demonstrated normal antibody responses to vaccinations and whether they harbored type I interferon-neutralizing auto-antibodies.

16 Jun 2022

Current evidence on cannabis use in palliative care

Scientists from Wellington, New Zealand, have conducted a systematic review to understand the effectiveness of medicinal cannabis in palliative care settings.

13 Jun 2022

RNA exosomes play a key role in B cell development, UTSW study suggests

New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system's ability to protect against infection.

13 Jun 2022

Study investigates SARS-CoV-2 escape from nirmatrelvir

Researchers assessed SARS-CoV-2 Alpha, Delta, and Omicron variants’ resistance to nirmatrelvir, a protease inhibitor of SARS-CoV-2.

10 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Monkeypox virus transmission via sexual contact

A new study discusses the transmission of monkeypox through sexual contact.

6 Jun 2022

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Researchers reviewed and analyzed data from SARS-CoV-2 serosurveys supported by the United States Centers for Disease Prevention and Control in the low- and middle-income countries.

6 Jun 2022

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

Common experiences of stigma in people living with Long Covid

The vast majority of individuals, both with and without a long COVID diagnosis, have experienced some form of stigma.

1 Jun 2022

HIV research enables knowledge transfer for improved COVID-19 response

Global virology and immunology networks that were originally developed for HIV vaccine research were rapidly adapted to study COVID-19.

31 May 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

Mapping the Types and Traits of Immune Cells

In this interview, News-Medical speaks to two researchers each discussing their respective studies that have contributed to the Human Cell Atlas; Dr. Chenqu Suo and Dr. Cecilia Domínguez Conde from the Wellcome Sanger Institute.

30 May 2022

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Researchers compared the polymer-nanoparticle hydrogel system and standard routes of delivery of broadly neutralizing antibodies against SARS-CoV-2 in a mouse model.

27 May 2022

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

A recent study posted to the bioRxiv* preprint server illustrated that specific chemokine antibodies aid in recognizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals with a desirable disease course.

26 May 2022

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

Researchers compared the efficacy of sotrovimab and molnupiravir in preventing severe COVID-19 outcomes among non-hospitalized and high-risk COVID-19 patients across England.

25 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Immunodeficiency News and Research

Further Reading

Researchers assess monkeypox clinical management guidelines worldwide

The feasibility of sperm cryopreservation for male COVID-19 patients

Research may open door to the design of a better structured rabies vaccine

HIV coinfection significantly impacts B cell response to SARS-CoV-2

Type I interferons play crucial role in fending off SARS-CoV-2

Current evidence on cannabis use in palliative care

RNA exosomes play a key role in B cell development, UTSW study suggests

Study investigates SARS-CoV-2 escape from nirmatrelvir

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Monkeypox virus transmission via sexual contact

Details of SARS-CoV-2 seroprevalence surveys supported by the US CDC

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

Common experiences of stigma in people living with Long Covid

HIV research enables knowledge transfer for improved COVID-19 response

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Mapping the Types and Traits of Immune Cells

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

The effectiveness of sotrovimab vs. molnupiravir in preventing severe COVID-19 outcomes in non-hospitalized high-risk COVID-19 adult patients

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

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