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What are the present challenges and future considerations in developing vaccines against mucosal respiratory viruses?

In a recent review, the former director of the National Institute of Allergy and Infectious Diseases and former chief medical advisor to the president of the United States (U.S.), Dr. Fauci, and his team review the roadblocks to developing effective vaccines against viruses that infect the human respiratory mucosa and discuss strategies for next-generation vaccine development against mucosal respiratory viruses

13 Jan 2023

Study on the ecology of viruses in urban rodents with special emphasis on SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers investigated whether commensal rodent pests such as rats and mice, sourced from sewers and urban settings, are exposed to and are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They also investigated viruses present in commensal rodents.

12 Jan 2023

Bivalent boosters tested against all SARS-CoV-2 Omicron lineages

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the impact of the bivalent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine on the antibody-mediated neutralization of the SARS-CoV-2 Omicron lineages.

11 Jan 2023

COVID-19 outcomes in Rituximab treated patients

A new report throws light on SARS-CoV-2 breakthrough infections in patients with certain joint diseases or musculoskeletal conditions who are on rituximab and compares the severity of COVID-19 outcomes in these patients whilst identifying potential risk factors for severe outcomes.

11 Jan 2023

MIS-C more common and severe than previously thought

In a recent study published in the JAMA Network Open journal, researchers compared the characteristics of multisystem inflammatory syndrome in children (MIS-C) and coronavirus disease 2019 (COVID-19).

10 Jan 2023

Circulating microparticle proteins predict placenta accreta spectrum before delivery

A recent study published in the journal Scientific Reports reported that circulating microparticle (CMP) proteins predict pregnancies complicated by placenta accreta spectrum (PAS).

9 Jan 2023

Study suggests air pollution is an important independent risk factor for asthma exacerbations in children living in urban areas

A new study reported that moderate levels of outdoor air pollutants, ozone, and fine particulate matter correlated to non-viral asthma attacks in children and adolescents who live in low-income urban areas.

9 Jan 2023

Researchers analyze targets of human T cell recognition against all coronaviruses

Researchers analyzed T cell reactivity against alpha and beta common cold coronaviruses (CoVs) [(CCC)] to inform the development of pan-CoV vaccine concepts.

9 Jan 2023

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

In a recent study posted to bioRxiv*, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

8 Jan 2023

Does the duration between SARS-CoV-2 infection and vaccination affect immunity?

In a recent study posted to the medRxiv* preprint server, researchers at Oregon Health & Science University assessed the impact of the duration between coronavirus disease 2019 (COVID-19) infection and vaccination on immunity against infection.

8 Jan 2023

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

A recent study published in the journal Circulation examines the immunological picture in this scenario, looking for clues to the etiology of this rare and potentially serious complication.

5 Jan 2023

Current research on gut microbial modulation with culinary herbs and spices

An article published in Food Chemistry elaborated on the health benefits of culinary herbs and spices.

5 Jan 2023

Seroprevalence study demonstrates vaccination could boost impaired humoral immunity against Omicron BQ.1.1 subvariant

Researchers conducted a multicenter, cross-sectional seroprevalence study in emergency departments of five hospitals in North Rhine-Westphalia, Germany, between August and September 2022. They assessed point seroprevalence and neutralization activity against Wu01, BA.4/5, and BQ.1.1.

5 Jan 2023

High burden of multi-food allergies among children and adults in the U.S.

A new study in the journal Annals of Allergy, Asthma & Immunology aimed to characterize the characteristics, prevalence, determinants, distribution, and psychosocial burden of multi-FA among adults and children in the US.

3 Jan 2023

Longitudinal seroprevalence study among pregnant people indicates waning of immunity from natural SARS-CoV-2 infections

Researchers evaluated the seroprevalence and durability of antibodies against SARS-CoV-2 nucleocapsid protein among pregnant individuals and investigated transplacental antibody transfer.

3 Jan 2023

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

Researchers evaluated the efficacy of small molecule drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro.

29 Dec 2022

Exploring plasma and nasal antibody responses to SARS-CoV-2 infection and vaccination

Researchers evaluated plasma and nasal antibody titers responses induced by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccinations among United Kingdom (UK) residents.

23 Dec 2022

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Researchers evaluated plasma samples from individuals vaccinated with a fourth booster dose of mono- or bivalent mRNA SARS-CoV-2 vaccine to evaluate the recognition and neutralization capacity against the ancestral (D614G) strain and the Omicron BQ.1.1 subvariant.

23 Dec 2022

Using the gut microbiome to understand and treat respiratory diseases

Researchers review the role of the gut microbiome in certain respiratory diseases.

22 Dec 2022

What are the long-term outcomes of critical COVID-19 patients?

Researchers assessed the long-term outcomes of critically ill coronavirus disease 2019 (COVID-19) patients.

21 Dec 2022

Immunoglobulin News and Research

What are the present challenges and future considerations in developing vaccines against mucosal respiratory viruses?

Study on the ecology of viruses in urban rodents with special emphasis on SARS-CoV-2

Bivalent boosters tested against all SARS-CoV-2 Omicron lineages

COVID-19 outcomes in Rituximab treated patients

MIS-C more common and severe than previously thought

Circulating microparticle proteins predict placenta accreta spectrum before delivery

Study suggests air pollution is an important independent risk factor for asthma exacerbations in children living in urban areas

Researchers analyze targets of human T cell recognition against all coronaviruses

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

Does the duration between SARS-CoV-2 infection and vaccination affect immunity?

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

Current research on gut microbial modulation with culinary herbs and spices

Seroprevalence study demonstrates vaccination could boost impaired humoral immunity against Omicron BQ.1.1 subvariant

High burden of multi-food allergies among children and adults in the U.S.

Longitudinal seroprevalence study among pregnant people indicates waning of immunity from natural SARS-CoV-2 infections

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

Exploring plasma and nasal antibody responses to SARS-CoV-2 infection and vaccination

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Using the gut microbiome to understand and treat respiratory diseases

What are the long-term outcomes of critical COVID-19 patients?

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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