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Sickle cell disease: A global call to action

Reducing the burden of Sickle Cell Disease (SCD) requires substantial financial and political commitment to improving data-collection, diagnosis, treatment and training - doing so will positively impact the lives of millions of patients and families worldwide - says a new Commission published in The Lancet Haematology journal.

12 Jul 2023

Whole genome sequencing shows promise for early diagnosis of genetic disorders in newborns, infants

A new national study, led by researchers at Tufts Medical Center in Boston, has found whole genome sequencing (WGS) to be nearly twice as effective as a targeted gene sequencing test at identifying abnormalities responsible for genetic disorders in newborns and infants.

11 Jul 2023

Caffeine found to be most effective for treating birth asphyxia

Brain damage caused by oxygen deficiency at birth is one of the main causes of death in newborns worldwide. Using a small animal model, researchers from the University Hospital Bonn (UKB) and DZNE tested treatment with 25 different active agents.

3 Jul 2023

The epidemiology of the Streptococcus agalactiae bacterium (group B Streptococcus [GBS]) in Southeast Asia

Researchers detected the presence of a Streptococcus agalactiae (group B Streptococcus) sequence type (ST) 283.

30 Jun 2023

Prenatal household air pollution linked to reduced birth weight and increased infant pneumonia risk

Air pollution at home during pregnancy affects the baby's weight and increases the risk of pneumonia. This study emphasizes the importance of using clean fuel stoves starting from the early stages of pregnancy.

25 Jun 2023

Blood-brain barrier model may lead to prevention of meningitis in newborns

Investigators in Israel and Italy have developed a model of the blood-brain barrier, studies of which may lead to prevention of meningitis in newborns.

22 Jun 2023

Newborn screening for "bubble-baby" disease boosts survival of children

Screening newborns for severe combined immunodeficiency disease (SCID) significantly increases the survival of children after bone marrow transplantation, a new North American study finds.

21 Jun 2023

Newborn screening facilitates early identification of infants with severe combined immunodeficiency

Introducing widespread screening of newborns for a deadly disease called severe combined immunodeficiency, or SCID, followed by early treatment boosted the five-year survival rate of children with the disorder from 73% before the advent of screening to 87% since, researchers report.

20 Jun 2023

Researchers identify Paenibacillus bacteria as responsible for postinfectious hydrocephalus in Uganda

In 2007, Yale pediatric neurosurgeon Steven Schiff, MD, visited his friend, Benjamin Warf, MD, at the CURE Children's Hospital of Uganda.

20 Jun 2023

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Give credit to your dad's gene for keeping you safe during those long months in your mother's womb.

20 Jun 2023

Female babies with congenital diaphragmatic hernia have about 32% higher mortality risk than males

A Johns Hopkins Children Center study using medical records from an international registry concludes that female babies with congenital diaphragmatic hernia (CDH) are slightly more likely to die within 30 to 60 days of birth than male babies with the same condition.

19 Jun 2023

Is vaginal microbiota transfer intervention for infants delivered by C-section beneficial to their neurodevelopment?

Researchers examined the impact of vaginal microbiota transfer on the neurodevelopment of infants born via cesarean section.

19 Jun 2023

Study offers a new perspective on the reproductive toxicity of phthalates

Prenatal exposure to chemicals called phthalates, which are used in hundreds of products, may lead to hormonal changes in females that could affect their future fertility, suggests a study in mice being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

In a new study, published today (15 June) in Nature Communications, a multi-centre team led by the Wellcome Sanger Institute, the University of Oslo, Imperial College London and UCL, has mapped for the first time the evolutionary timeline and population distribution of Escherichia coli’s protective outer capsule, which is responsible for the bacterium’s virulence.

15 Jun 2023

Study provides a more complete picture of sickle cell disease mortality burden

A new study suggests the number of deaths due to sickle cell disease is 11 times higher than what is indicated from mortality data sources alone. Sickle cell disease is not just underdiagnosed, but it also increases risk of infection and of death from conditions like stroke, heart problems, kidney problems, and pregnancy complications.

13 Jun 2023

Giving birth outside of working hours in England does not carry higher risk of infant mortality

A new study suggests that between 2005 and 2014, for almost all births in England, being born outside of working hours did not carry a significantly higher risk of death to the baby from anoxia (lack of oxygen) or trauma, when compared to births during working hours.

13 Jun 2023

ACMG publishes updated recommendations for CFTR carrier screening

The American College of Medical Genetics and Genomics (ACMG) has released updated recommendations for CFTR carrier screening –Updated recommendations for CFTR carrier screening: A position statement of the American College of Medical Genetics and Genomics.

13 Jun 2023

Study reveals alarming pediatric antibiotic prescribing practices in Madagascar, Senegal, and Cambodia

In a recent article published in the journal PLOS Medicine, researchers performed a prospective, longitudinal study to estimate the proportion of outpatient consultations resulting in inappropriate antibiotic prescriptions in young children in three low- and middle-income countries (LMICs), Madagascar, Senegal, and Cambodia.

13 Jun 2023

VLA1553 vaccine candidate for chikungunya disease produces an immune response in a phase 3 trial

The VLA1553 vaccine candidate for chikungunya disease was generally well tolerated and produced an immune response in 99% (263/266) of participants, according to a phase 3 randomized controlled trial published in The Lancet.

12 Jun 2023

Global study provides high-quality data to improve treatment of newborn babies with sepsis

A global observational study, which involved more than 3,200 newborn babies suffering from sepsis in 19 hospitals in 11 countries, has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness.

8 Jun 2023

Newborn News and Research

Sickle cell disease: A global call to action

Whole genome sequencing shows promise for early diagnosis of genetic disorders in newborns, infants

Caffeine found to be most effective for treating birth asphyxia

The epidemiology of the Streptococcus agalactiae bacterium (group B Streptococcus [GBS]) in Southeast Asia

Prenatal household air pollution linked to reduced birth weight and increased infant pneumonia risk

Blood-brain barrier model may lead to prevention of meningitis in newborns

Newborn screening for "bubble-baby" disease boosts survival of children

Newborn screening facilitates early identification of infants with severe combined immunodeficiency

Researchers identify Paenibacillus bacteria as responsible for postinfectious hydrocephalus in Uganda

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Female babies with congenital diaphragmatic hernia have about 32% higher mortality risk than males

Is vaginal microbiota transfer intervention for infants delivered by C-section beneficial to their neurodevelopment?

Study offers a new perspective on the reproductive toxicity of phthalates

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

Study provides a more complete picture of sickle cell disease mortality burden

Giving birth outside of working hours in England does not carry higher risk of infant mortality

ACMG publishes updated recommendations for CFTR carrier screening

Study reveals alarming pediatric antibiotic prescribing practices in Madagascar, Senegal, and Cambodia

VLA1553 vaccine candidate for chikungunya disease produces an immune response in a phase 3 trial

Global study provides high-quality data to improve treatment of newborn babies with sepsis

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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