Reverse Transcriptase News and Research

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Breakthrough Alzheimer's discovery

A new study has found that the neurons in the brain can alter their genetic make-up unlike other cells of the body which remain constant.

22 Nov 2018

New assay may help improve both sarcoma diagnosis and treatment

Sarcomas are rare tumors that are often misdiagnosed. Specific recurrent chromosomal rearrangements, known as translocations, can serve as essential diagnostic markers and are found in about 20 percent of sarcomas.

20 Aug 2018

UCLA researchers have blueprint of telomerase that plays major role in cancer, aging

Cancer, aging-related diseases and other illnesses are closely tied to an important enzyme called "telomerase." UCLA researchers report in the journal Cell the deepest scientific understanding yet of this once-mysterious enzyme, whose catalytic core -- where most of its activity occurs -- can now be seen in near atomic resolution.

7 Jun 2018

HIV patients on single-tablet regimen show better outcomes than those taking multiple pills

HIV patients on a single-tablet daily regimen had better treatment retention and viral suppression than patients taking multiple pills, in a study by a Michael E. DeBakey Veterans Affairs Medical Center researcher and his colleagues.

18 May 2018

New long-acting delivery system has potential to lessen side effects from NRTIs

An HIV diagnosis, while no longer constituting a death sentence, brings with it a lifetime, daily regimen of medication to help continually combat the virus.

27 Mar 2018

IPM begins first clinical trial of vaginal rings to prevent HIV in women

The nonprofit International Partnership for Microbicides announced today the start of the first clinical trial of vaginal rings designed to slowly release the antiretroviral drug dapivirine over three months to prevent HIV in women.

13 Dec 2017

Novel gene expression signature assay could help enhance lymphoma management

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer and the most frequently diagnosed non-Hodgkin lymphoma worldwide (nearly 40% of cases). Recent advancements indicate that both the prognosis and choice of treatment of DLBCL may depend on identifying its molecular subtype.

17 Oct 2017

Plant compound found to be effective against drug-resistant HIV

A plant found throughout Southeast Asia traditionally used to treat arthritis and rheumatism contains a potent anti-HIV compound more powerful than the drug AZT, according to a new paper published in the Journal of Natural Compounds.

15 Jun 2017

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Rotifers are tough, microscopic organisms highly resistant to radiation and repeated cycles of dehydration and rehydration.

6 Jun 2017

Analyzing single-cell RNA data in pre-malignant tumors

RNA sequencing is basically the isolation of RNA from cells and the use of reverse transcriptase to turn the RNA into DNA. You can then use your standard DNA sequencing technologies to quantify the cDNA that you obtained from the reverse transcription reaction.

12 May 2017

New gene-based blood tests can reliably detect previously unidentifiable forms of skin cancer

Genetic testing of tumor and blood fluid samples from people with and without one of the most aggressive forms of skin cancer has shown that two new blood tests can reliably detect previously unidentifiable forms of the disease.

3 Apr 2017

JAX researchers unravel mechanism that enables cancer cells to survive and divide

Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory Professor Roel Verhaak reports in Nature Genetics on a newly discovered telomere maintenance mechanism.

31 Jan 2017

Added benefit of combination drug for HIV-infected patients not proven

The drug combination emtricitabine/tenofovir alafenamide is approved in combination with other antiviral agents for the treatment of adults and adolescents infected with human immunodeficiency virus type 1 (HIV-1).

19 Aug 2016

Researchers find distinct, non-identical differences among retroviruses

In the most comprehensive study of its kind, researchers in the report that most types of retroviruses have distinct, non-identical virus structures.

6 Jul 2016

Penn researchers develop low-cost genetic test for Zika virus

University of Pennsylvania engineers have developed a rapid, low-cost genetic test for the Zika virus.

6 Jul 2016

Utah researchers find way to use power of protease to destroy budding AIDS virus

When new AIDS virus particles bud from an infected cell, an enzyme named protease activates to help the viruses mature and infect more cells. That's why modern AIDS drugs control the disease by inhibiting protease.

10 Jun 2016

CML treatment-free remission criteria outlined

Treatment-free remission may be feasible in many patients with chronic myeloid leukaemia, say researchers who set out clinical and logistical requirements for discontinuing tyrosine kinase inhibitor therapy.

18 May 2016

Research provides new insight into cellular composition of IDH1-mutant gliomas

Winner of the Preuss Research Award, Andrew Venteicher, MD, PhD, presented his research, Cellular Architecture of Human IDH1-mutant Gliomas Revealed Using Single-cell RNA Sequencing, during the 2016 American Association of Neurological Surgeons Annual Scientific Meeting.

5 May 2016

NHS England to provide crucial funding for Janssen's HIV treatment, REZOLSTA

Janssen-Cilag Ltd today announced that NHS England will provide crucial funding for its once-daily, fixed-dose combination of darunavir and the pharmacoenhancer, cobicistat, called REZOLSTA.

31 Mar 2016

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

A study of obesity and related metabolic changes on bladder cancer incidence and deaths, and a plan to use stem cells to grow novel urinary tubes are among 10 research projects awarded funding by the Johns Hopkins Greenberg Bladder Cancer Institute.

7 Mar 2016