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New PARP inhibitor shows early responses in patients with advanced BRCA-related cancers

An investigational new PARP inhibitor, BMN 673, is showing early responses in patients with heavily pretreated, advanced, BRCA-related cancers of the breast and ovary, according to phase I clinical trial results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

23 Oct 2013

Angiochem presents results of Phase 2 study with ANG1005 in breast cancer patients with brain metastases

Angiochem, a clinical stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier (BBB), announced that the complete analysis results of a Phase 2 clinical study with ANG1005, a novel paclitaxel-peptide drug conjugate, in breast cancer patients with brain metastasis were presented today at the 2013 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference.

23 Oct 2013

Pfizer announces top-line results from phase 3b studies with Lyrica Capsules

Pfizer Inc. (NYSE:PFE) announced top-line results from two phase 3b, placebo-controlled studies with Lyrica® (pregabalin) Capsules CV in patients with fibromyalgia (FM) and painful diabetic peripheral neuropathy (DPN), respectively.

19 Oct 2013

Diaphragm pacing systems improve quality of life for ALS patients

Respiratory failure is one of the major complications associated with amyotrophic lateral sclerosis. The quest for alternative approaches for treating respiratory failure has led to the study, and subsequent FDA approval, of diaphragm pacing for use in ALS patients. However, there are still important unanswered questions about its benefit and impact.

18 Oct 2013

NEJM publishes Celgene’s Abraxane phase III study results

Published today in the New England Journal of Medicine, a phase III clinical trial of Abraxane (paclitaxel formulated as albumin-bound nanoparticles) in combination with gemcitabine in treatment-naive patients with metastatic pancreatic cancer demonstrated a statistically significant improvement in overall survival compared to patients receiving gemcitabine alone [(median of 8.5 vs. 6.7 months) (HR 0.72, P=0.000015)].

17 Oct 2013

Study focuses on vaccine-preventable illnesses in myasthenia gravis patients

A study presented at the annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine is considered a good first step in collecting data on vaccine-preventable illnesses in patients with myasthenia gravis, a neuromuscular disorder causing weakness and rapid fatigue of voluntary muscles.

17 Oct 2013

Non-Hispanic black, Hispanic patients less likely to experience metabolic syndrome remission

The impact of bariatric surgery on risk factors for cardiovascular disease depends on a variety of factors, including the type of surgery, sex of the patient, ethnic background, and pre-surgery body mass index, according to a Kaiser Permanente study published today in Annals of Surgery.

16 Oct 2013

UC researchers receive $2.1M grant from NIH to study molecular mechanisms of muscle fatigue

University of Cincinnati (UC) researchers have been awarded a five-year, $2.1 million grant from the National Institutes of Health (NIH) to study an isoform that plays a critical role in human resistance to fatigue.

16 Oct 2013

Research shows age does not affect symptom recovery after sports-related concussion

Recent scientific findings have raised the fear that young athletes may fare worse after sustaining a sports-related concussion than older athletes.

15 Oct 2013

Results announced for Phase II PRECEDENT trial of vintafolide for treatment of platinum-resistant ovarian cancer

Merck, known as MSD outside the United States and Canada, (NYSE: MRK) and Endocyte, Inc. (NASDAQ: ECYT) today announced the online publication of results from the randomized Phase II PRECEDENT trial for vintafolide (MK-8109/EC145), an investigational folate small molecule drug conjugate (SMDC), in the Journal of Clinical Oncology (JCO), the official journal of the American Society of Clinical Oncology.

15 Oct 2013

Baylor provides AED demonstrations on how to save people who experience sudden cardiac arrest

Exiting an elevator, a man crumples to the floor just outside the elevator. You, an innocent bystander, freeze. Then, you see the glass case on the wall with the heart and lightening decal. Whether or not you reach for that case and open it is a life or death decision for the stranger lying at the elevator doors.

15 Oct 2013

Sleep duration negatively impacts on self-rated health

Individuals who experience long or short sleep durations are more likely to report poor self-rated health than healthy sleepers, Korean study findings suggest.

14 Oct 2013

IV lidocaine infusion provides significant pain relief to fibromyalgia patients

Patients with fibromyalgia resistant to more routine therapies have a new pain relief treatment available, according to a study presented at the ANESTHESIOLOGY 2013 annual meeting.

14 Oct 2013

Pulmonary rehabilitation underused in COPD

Data from an Australian hospital show that chronic obstructive pulmonary disease patients admitted for exacerbations are rarely referred for pulmonary rehabilitation, despite it being strongly recommended by national treatment guidelines.

11 Oct 2013

Crucial role of orthopedic surgeons in diagnosing mTBI among trauma care patients

In the United States, approximately 1.4 million people suffer a traumatic brain injury (TBI) each year. Of those injuries, three out of four are minor TBI (mTBI)-a head injury that causes a temporary change in mental status including confusion, an altered level of consciousness, or perceptual or behavioral impairments.

11 Oct 2013

Adding danoprevir to treatment regimen for hepatitis C patients leads to high rates of remission

The addition of danoprevir to the current treatment regimen for patients with hepatitis C leads to high rates of remission, according to a new article in Gastroenterology, the official journal of the American Gastroenterological Association.

11 Oct 2013

Bluhm Institute enrolls first patient in SALUS trial to evaluate movable, non-metallic heart valve

Northwestern's Bluhm Cardiovascular Institute has enrolled its first participant in SALUS, a clinical trial studying the effectiveness of a prosthetic aortic heart valve that can be placed without open-heart surgery.

10 Oct 2013

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

10 Oct 2013

FMCNA encourages dialysis patients to get vaccinated against flu

With early cases of seasonal flu already being reported in the U.S., Fresenius Medical Care North America (FMCNA), the nation's leading network of dialysis facilities, is strongly encouraging dialysis patients to get flu shots to protect themselves against this common infectious disease.

9 Oct 2013

People with poor reading skills are likely to be less healthy

People with poor reading skills are likely to be less healthy than those who read easily, according to recent research. Literacy skills are important for keeping in good shape.

8 Oct 2013

Fatigue News and Research

New PARP inhibitor shows early responses in patients with advanced BRCA-related cancers

Angiochem presents results of Phase 2 study with ANG1005 in breast cancer patients with brain metastases

Pfizer announces top-line results from phase 3b studies with Lyrica Capsules

Diaphragm pacing systems improve quality of life for ALS patients

NEJM publishes Celgene’s Abraxane phase III study results

Study focuses on vaccine-preventable illnesses in myasthenia gravis patients

Non-Hispanic black, Hispanic patients less likely to experience metabolic syndrome remission

UC researchers receive $2.1M grant from NIH to study molecular mechanisms of muscle fatigue

Research shows age does not affect symptom recovery after sports-related concussion

Results announced for Phase II PRECEDENT trial of vintafolide for treatment of platinum-resistant ovarian cancer

Baylor provides AED demonstrations on how to save people who experience sudden cardiac arrest

Sleep duration negatively impacts on self-rated health

IV lidocaine infusion provides significant pain relief to fibromyalgia patients

Pulmonary rehabilitation underused in COPD

Crucial role of orthopedic surgeons in diagnosing mTBI among trauma care patients

Adding danoprevir to treatment regimen for hepatitis C patients leads to high rates of remission

Bluhm Institute enrolls first patient in SALUS trial to evaluate movable, non-metallic heart valve

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

FMCNA encourages dialysis patients to get vaccinated against flu

People with poor reading skills are likely to be less healthy

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