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Scientists discover new causes for neurodegeneration

Diseases that cause neurons to break-down, such as Alzheimer's, Multiple Sclerosis and Creutzfeldt-Jakob disease (Mad Cow Disease), continue to be elusive to scientists and resistant to treatments.

25 Oct 2007

Diffusion tensor imaging shows structural changes in mild traumatic brain injury

Researchers report that diffusion tensor imaging can identify structural changes in the white matter of the brain that correlates to cognitive deficits even in patients with mild traumatic brain injury.

25 Oct 2007

Valsartan might help prevent Alzheimer's disease

Alzheimer disease (AD), a neurodegenerative disease that is the most common form of dementia, is characterized by the formation in the brain of plaques containing misfolded beta-amyloid protein.

25 Oct 2007

Synthetic form of THC is an effective anti-depressant at low doses

A new neurobiological study has found that a synthetic form of THC, the active ingredient in cannabis, is an effective anti-depressant at low doses.

24 Oct 2007

Potent inhibitor of Kinesin CENP-E demonstrates tumor cell inhibition

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline.

24 Oct 2007

Orexigen presents findings on obesity drug candidates

Orexigen Therapeutics, Inc., a biopharmaceutical company focused on the treatment of central nervous system (CNS) disorders including obesity, has presented the results of a preclinical study that further supports the Company's understanding of an aspect of the mechanism of action of Contrave, one of its two late-stage obesity drug candidates.

24 Oct 2007

Experimental cancer pharmaceuticals under trial

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

24 Oct 2007

Australian researchers stelp closer to discovering the cause of epileptic seizures

Scientists still do not know what causes epileptic seizures, but researchers from Melbourne's Howard Florey Institute are one step closer to solving this puzzle with the help of their newly developed genetically modified epileptic mouse.

22 Oct 2007

The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases

A phenomenon considered healthy for cells, such as the accumulation of long chains of glucose (glycogen), which tissues store for energy purposes, is harmful for neurons.

22 Oct 2007

Brain mechanism may help some cope better in stressful situations

According to researchers in the U.S. a mechanism found in some people's brain could be the key to them staying relaxed in stressful situations.

22 Oct 2007

West Nile virus' spread through nerve cells linked to serious complication

Scientists believe they have found an explanation for a puzzling and serious complication of West Nile virus infection.

19 Oct 2007

Researcher identify specific cell that causes eye cancer, disproving long-held theory

Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development.

19 Oct 2007

Mice offer clues to the roots of human resilience

When faced with adversity, some people succumb to debilitating psychological diseases including posttraumatic stress disorder and depression, while others are able to remain remarkably optimistic.

19 Oct 2007

Ability to cope with stress, depression linked to variations in brain structure and function

Researchers at UT Southwestern Medical Center have found in mice that the ability or inability to cope with stress is linked to specific differences in the way brain cells communicate with each other.

19 Oct 2007

Childhood epilepsy research offers new hope for seizure control

18 Oct 2007

Tolerance to inhalants may be caused by changes in gene expression

Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered.

18 Oct 2007

Accessory protein determines whether pheromones are detected

Pheromones are like the molecules you taste as you chomp on a greasy french fry: big and fatty.

17 Oct 2007

New therapy for chronic spasticity and rigidity

Research led by scientists at the University of California, San Diego (UCSD) School of Medicine has identified a target with potential as an effective new therapy for chronic spasticity and rigidity, a painful condition that often results from spinal cord injury.

17 Oct 2007

Study identifies pathway required for normal reproductive development

Massachusetts General Hospital (MGH) clinical researchers, in collaboration with basic scientists from the University of California, Irvine (UC Irvine) have identified a new molecular pathway required for normal development of the reproductive, olfactory and circadian systems in both humans and mice.

17 Oct 2007