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Cancer cells pull off 'Houdini' escape to evade chemotherapy

Scientists have revealed for the first time that cancer cells can reverse a process which irrevocably commits normal cells to die, in a study published in the British Journal of Cancer.

6 Jan 2009

Stem cells from human testes can change into other body tissues

Scientists at the Stanford University School of Medicine and at UC-San Francisco have succeeded in isolating stem cells from human testes.

5 Jan 2009

Obesity may contribute to the development of ovarian cancer

A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight.

5 Jan 2009

Prolonged nevirapine in breast-fed babies prevents HIV infection but leads to drug-resistant HIV

Babies born to HIV-positive mothers and given the antiretroviral drug nevirapine through the first six weeks of life to prevent infection via breast-feeding are at high risk for developing drug-resistant HIV if they get infected anyway, a team of researchers report.

5 Jan 2009

New insight into critical molecular mechanisms involved in aggressive childhood cancer

A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children.

5 Jan 2009

Appropriate use criteria for coronary revascularization

If you're committed to fitness, the decision to climb a couple of flights of stairs rather than take the elevator is clear. But if you develop chest pain on the way up, deciding how to treat the symptoms of clogged arteries in your heart is much more complicated.

5 Jan 2009

Metadherin gene plays dual role in breast cancers with poor prognosis

A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy.

5 Jan 2009

Discovery of new tumor suppressor for lung cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.

5 Jan 2009

Discovery of new syndrome associated with severe congenital neutropenia

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3).

5 Jan 2009

Parkinson's increases risk for orthopaedic conditions

Although Parkinson's disease (PD) is a neurological disorder, according to an article in the January 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons, the disease also increases a person's risk of experiencing complicated orthopaedic conditions.

5 Jan 2009

Molecular imaging enables earlier, individualized treatment of thyroid cancer

In a study to determine the diagnostic value of molecular imaging in nodal staging of patients with thyroid cancer, researchers were able for the first time to accurately distinguish between cancerous cells in regional lymph nodes and normal residual thyroid tissue directly after surgery.

5 Jan 2009

Inherited factors play key role in breast cancer

New research in mice and five independent collections of human breast tumors has enabled National Cancer Institute (NCI) scientists to confirm that genes for factors contributing to susceptibility for breast cancer metastasis can be inherited.

5 Jan 2009

First-degree family history of prostate cancer does not affect some treatment outcomes

In a first of its kind study, a first-degree family history of prostate cancer has no impact on the treatment outcomes of prostate cancer patients treated with brachytherapy (also called seed implants), and patients with this type of family history have clinical and pathologic characteristics similar to men with no family history at all, according to a January 1 study in the International Journal of Radiation Oncology*Biology*Physics , the official journal of the American Society for Radiation Oncology.

5 Jan 2009

Bionovo publishes discoveries in predictable tissue selectivity for selective estrogen receptor modulators platform

Bionovo, Inc. has announced results describing predictable estrogen regulatory elements that can be used to identify estrogenic drugs that are safer.

5 Jan 2009

Study links obesity to elevated risk of ovarian cancer

5 Jan 2009

Why prostate cancer patients fail hormone deprivation therapy

The hormone deprivation therapy that prostate cancer patients often take gives them only a temporary fix, with tumors usually regaining their hold within a couple of years.

1 Jan 2009

Study links MiR-29 molecule to muscle maturation, muscle cancer

Researchers at The Ohio State University Comprehensive Cancer Center have discovered that a molecule implicated in leukemia and lung cancer is also important in muscle repair and in a muscle cancer that strikes mainly children.

1 Jan 2009

Scientists genetically grab PTEN by the tail to curtail cancer

When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.

1 Jan 2009

Candesartan shown to be safe new therapy for genetic heart disease

A new clinical trial suggests that long-term use of candesartan, a drug currently used to treat hypertension, may significantly reduce the symptoms of genetic heart disease.

1 Jan 2009

Researchers engineer pancreatic cell transplants to evade immune response

In a finding that could significantly influence the way type 1 diabetes is treated, researchers at Albert Einstein College of Medicine of Yeshiva University have developed a technique for transplanting insulin-producing pancreatic cells that causes only a minimal immune response in recipients.

1 Jan 2009