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Study explains why some cancer vaccines are not as effective as hoped

A research report published in the September 2012 issue of the Journal of Leukocyte Biology offers a possible explanation of why some cancer vaccines are not as effective as hoped, while at the same time identifies a new therapeutic strategy for treating autoimmune problems. In the report, scientists suggest that cancer, even in the very early stages, produces a negative immune response from dendritic cells, which prevent lymphocytes from working against the disease.

31 Aug 2012

Glaucoma and cell death: an interview with Dr. Vivek Gupta

Glaucoma is normally caused by increased pressure of aqueous humour fluid in the eye. A defining feature of this disease is destruction of a particular type of cells in the retina called retinal ganglion cells and excavation of the optic disc region.

31 Aug 2012

Weill Cornell Medical College receives three new research grants for translational blood cancer study

Weill Cornell Medical College has been awarded three new research grants from the Leukemia & Lymphoma Society totaling $1.8 million. The funds will support critically-needed translational research for blood cancers, accelerating promising discoveries from the laboratory to the patient's bedside.

31 Aug 2012

Renal artery stent revascularization reduces blood pressure in patients with severe hypertension

Patients with uncontrolled renovascular hypertension saw a significant improvement in their blood pressure with renal artery stent deployment. The multicenter HERCULES trial, evaluating the safety and effectiveness of the RX Herculink Elite Stent, found that patients with higher blood pressure levels at baseline had the most dramatic reduction in blood pressure following intervention.

31 Aug 2012

Researchers discover new immune response mechanism during infection

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a new "first response" mechanism that the immune system uses to respond to infection. The findings challenge the current understanding of immunity and could lead to new strategies for boosting effectiveness of all vaccines. The study, conducted in mice, published online today in the journal Immunity.

31 Aug 2012

Studies examine how PML gene regulates the fatty acid oxidation pathway

Two papers led by scientific teams from the Cancer Genetics Program at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms underlying cellular energy and metabolism and, at the same time, highlight both the challenges and opportunities of genetic approaches to cancer treatment.

31 Aug 2012

Scientists open new front against cause of sleeping sickness

Scientists of the Antwerp Institute of Tropical Medicine (ITG) opened a new front against the cause of sleeping sickness. This parasite is transmitted between humans by tsetse flies. The researchers learned a bacterium living in those flies how to produce antibodies against the parasite. Application in the field is still a long way of, but the technique shows quite some promise.

31 Aug 2012

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

Removing the entire pancreas in patients with cancer or precancerous cysts in part of the organ does not result in unmanageable diabetes — as many physicians previously believed, research at Mayo Clinic in Florida has found.

30 Aug 2012

UAB Center of Research Translation to improve health of patients with gout, hyperuricemia

The University of Alabama at Birmingham is establishing a Center of Research Translation to improve the health of an increasing number of patients with gout and hyperuricemia.

30 Aug 2012

UH pharmacologist examines age-related oxidative, inflammatory stress

Gaining new insight to managing sodium balance and blood pressure, investigators at the University of Houston (UH) College of Pharmacy believe their work may identify future therapeutic targets to control hypertension.

30 Aug 2012

Southampton Traffic Light test could easily diagnose liver fibrosis and cirrhosis

A new 'traffic light' test devised by Dr Nick Sheron and colleagues at University of Southampton and Southampton General Hospital could be used in primary care to diagnose liver fibrosis and cirrhosis in high risk populations more easily than at present.

30 Aug 2012

Fractional flow reserve CT shows potential to non-invasively identify coronary artery disease

A study published in the most recent issue of the Journal of the American Medical Association (JAMA) presented encouraging news regarding physicians' ability to determine blood flow and associated coronary artery disease (CAD) using noninvasive CT scanning technology.

30 Aug 2012

Johns Hopkins team creates synthetic protein that can help locate tumors

Johns Hopkins researchers have created a synthetic protein that, when activated by ultraviolet light, can guide doctors to places within the body where cancer, arthritis and other serious medical disorders can be detected.

30 Aug 2012

Nipro Diagnostics, NextGen enter agreement for TRUEresult blood glucose monitoring system

NextGen Healthcare Information Systems, LLC, a wholly owned subsidiary of Quality Systems, Inc. and a leading provider of healthcare information systems and connectivity solutions, announced today it has entered into an agreement with Nipro Diagnostics, Inc. to integrate its TRUEresult blood glucose monitoring system into the NextGen Ambulatory EHR.

30 Aug 2012

Sicor Biotech receives FDA approval for tbo-filgrastim to treat severe neutropenia

The U.S. Food and Drug Administration today approved Sicor Biotech's tbo-filgrastim to reduce the time certain patients receiving cancer chemotherapy experience severe neutropenia, a decrease in infection-fighting white blood cells called neutrophils.

30 Aug 2012

CNIO team generates transgenic mouse model for aplastic anaemia associated with short telomeres

Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

30 Aug 2012

Tunes and T-shirts for cardiac rehabilitation

Two studies presented at the European Society of Cardiology Congress in Munich, Germany, showed how researchers are developing innovative approaches to help patients get the most out of cardiac rehabilitation.

29 Aug 2012

Childhood coagulation marker levels distinct from adulthood

Levels of key coagulation markers significantly vary with age in children, research reveals, potentially affecting the diagnosis and treatment of pediatric thrombotic and hemorrhagic disease.

29 Aug 2012

Vitamin to the rescue in fight with ‘superbugs’

High doses of vitamin B3 may help fight against so called “superbugs” such as methicillin-resistant Staphylococcus aureus, show study results.

29 Aug 2012

Genetic investigation of tribes may explain why East Asians have lower skin cancer rates

Genetic investigation of a Malaysian tribe may tell scientists why East Asians have light skin but lower skin cancer rates than Europeans, according to a team of international researchers. Understanding the differences could lead to a better way to protect people from skin cancer.

29 Aug 2012

Blood News and Research

Study explains why some cancer vaccines are not as effective as hoped

Glaucoma and cell death: an interview with Dr. Vivek Gupta

Weill Cornell Medical College receives three new research grants for translational blood cancer study

Renal artery stent revascularization reduces blood pressure in patients with severe hypertension

Researchers discover new immune response mechanism during infection

Studies examine how PML gene regulates the fatty acid oxidation pathway

Scientists open new front against cause of sleeping sickness

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

UAB Center of Research Translation to improve health of patients with gout, hyperuricemia

UH pharmacologist examines age-related oxidative, inflammatory stress

Southampton Traffic Light test could easily diagnose liver fibrosis and cirrhosis

Fractional flow reserve CT shows potential to non-invasively identify coronary artery disease

Johns Hopkins team creates synthetic protein that can help locate tumors

Nipro Diagnostics, NextGen enter agreement for TRUEresult blood glucose monitoring system

Sicor Biotech receives FDA approval for tbo-filgrastim to treat severe neutropenia

CNIO team generates transgenic mouse model for aplastic anaemia associated with short telomeres

Tunes and T-shirts for cardiac rehabilitation

Childhood coagulation marker levels distinct from adulthood

Vitamin to the rescue in fight with ‘superbugs’

Genetic investigation of tribes may explain why East Asians have lower skin cancer rates

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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