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WSU researchers to test novel hypothesis that cardiolipin deficiency leads to disruption of TCA cycle

Barth Syndrome (BTHS) is a rare and serious genetic disorder that primarily affects males and is passed from mother to son; women who are carriers do not show symptoms of the disorder. Fifty percent of children born to a mother who is a carrier will inherit the defective gene, and all daughters born to an affected man will be carriers. BTHS is caused by a mutation in the tafazzin gene that results in decreased production of cardiolipin, an essential lipid for energy metabolism.

8 Aug 2012

About half of adults with type 2 diabetes experience acute and chronic pain

Almost half of adults with type 2 diabetes report acute and chronic pain, and close to one quarter report neuropathy, fatigue, depression, sleep disturbance and physical or emotional disability, according to a study of more than 13,000 adults conducted by researchers at the San Francisco VA Medical Center, the University of California, San Francisco and the Kaiser Permanente Division of Research in Oakland, CA. The researchers also found significant rates of shortness of breath, nausea and constipation.

8 Aug 2012

Statins and diabetes both increase cataract risk

Patients using cholesterol-lowering statin drugs may be at increased risk of developing age-related cataracts, according to a study - "Age-related Cataract Is Associated with Type 2 Diabetes and Statin Use", in the August issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

8 Aug 2012

Neutral-pressure IV connector eliminates catheter-related bloodstream infections in cancer patients

A neutral-pressure IV needleless connector was associated with complete elimination of catheter-related bloodstream infections (CRBSI) in a successful device trial at a large cancer center in the six-month period following implementation of the device.

8 Aug 2012

Tips to avoid and cope with kidney stones

Summer can mean more than just an increase in temperatures, humidity and outdoor physical activity. It can also mean an increased risk of kidney stones, which affect approximately 3.8 million people in the United States and are on the rise.

8 Aug 2012

Variations in RORA gene can lead to post-traumatic stress disorder

Investigators at Boston University School of Medicine (BUSM) and Veterans Affairs (VA) Boston Healthcare System have identified a new gene linked to post-traumatic stress disorder (PTSD).

8 Aug 2012

New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

Chemotherapy kills tumor cells, but it also wreaks havoc on the rest of the body. A team of researchers led by Igor Roninson of the South Carolina College of Pharmacy just reported the discovery of a new class of drugs that reduces the adverse effects of cellular damage from chemotherapy.

8 Aug 2012

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes.

8 Aug 2012

UMass Medical, Serum Institute of India partner on anti-rabies monoclonal antibody pivotal trial

A pivotal clinical trial for an anti-rabies human monoclonal antibody (RMAb) being developed through a collaborative partnership between MassBiologics of the University of Massachusetts Medical School and the Serum Institute of India, Ltd., is starting to enroll patients.

8 Aug 2012

Older men with higher levels of free testosterone more likely to develop prostate cancer

New research finds older men with higher levels of free testosterone have an increased risk of prostate cancer. Australian researchers spent a decade exploring the testosterone-prostate cancer connection by comparing natural testosterone levels of men in their 70s and 80s, those with prostate cancer and without.

8 Aug 2012

RCPA’s new factsheets to breakdown the mystery of pathology

Pathology is a section of the healthcare system that takes place behind the scenes, tucked away in laboratories and, as a result, is an area of medicine that is largely misunderstood. Often pathology can open up a plethora of questions such as: why do I need a pathology test; where can I have a test; how safe is the testing; how is a pathology test fee calculated; and how should I go about genetic testing?

7 Aug 2012

Leptin polymorphism combinations influence BMI in Chinese

The presence of genetic variants in both the leptin gene and the gene for its receptor may predispose Chinese individuals to obesity, report researchers.

7 Aug 2012

Study signals biomarker hope for monitoring COPD

The biomarkers desmosines and C-reactive protein could be used to assess disease severity in chronic obstructive pulmonary disease, show the results of a Swedish study.

7 Aug 2012

Taking the heat out of tonsillectomy

Cooling of the spaces in which the tonsils are lodged during tonsillectomy, reduces post-operative pain and accelerates healing, report researchers.

7 Aug 2012

Creating new non-influenza vaccines: an interview with Julie Phillips, CEO of BioDiem

BioDiem recently signed a collaborative agreement with The Royal Melbourne Institute of Technology (RMIT) for the development of non-influenza vaccines using BioDiem’s proprietary live attenuated influenza virus (LAIV) technology.

7 Aug 2012

Orexigen Therapeutics reports net loss of $16.7 million for second quarter 2012

Orexigen Therapeutics, Inc., a biopharmaceutical company focused on the treatment of obesity, today announced financial results for the second quarter of 2012.

7 Aug 2012

Study suggests race-specific cutoff points for a diabetes diagnostic test

Healthcare providers should take into account differences among racial groups when using hemoglobin A1C levels to diagnose and monitor diabetes, new research from Beth Israel Deaconess Medical Center suggests.

7 Aug 2012

Advances in HIV/AIDS therapy and the International AIDS Conference: an interview with Professor Sharon Lewin

The anti-HIV drugs, also known as anti-retroviral therapy, came about in the mid ‘90’s. These involved using at least 3 different drugs together.

7 Aug 2012

Scientists discover biological marker that may help identify patients’ response to antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.

7 Aug 2012

Clinical trial targets breast cancer cells by injecting trastuzumab directly into the spinal fluid

In two to five percent of women with breast cancer, tumor cells migrate into the spinal fluid invading the tissue surrounding the brain and spinal cord called the meninges. While a rare complication, the condition is challenging because there is no agreed-upon standard of treatment, leaving little hope for patients affected. Northwestern Medicine- researchers are currently examining a novel approach to delivering an FDA approved drug that they hope will advance research for this type of cancer and lead to discoveries that may improve outcomes in the future.

7 Aug 2012

Blood News and Research

WSU researchers to test novel hypothesis that cardiolipin deficiency leads to disruption of TCA cycle

About half of adults with type 2 diabetes experience acute and chronic pain

Statins and diabetes both increase cataract risk

Neutral-pressure IV connector eliminates catheter-related bloodstream infections in cancer patients

Tips to avoid and cope with kidney stones

Variations in RORA gene can lead to post-traumatic stress disorder

New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

UMass Medical, Serum Institute of India partner on anti-rabies monoclonal antibody pivotal trial

Older men with higher levels of free testosterone more likely to develop prostate cancer

RCPA’s new factsheets to breakdown the mystery of pathology

Leptin polymorphism combinations influence BMI in Chinese

Study signals biomarker hope for monitoring COPD

Taking the heat out of tonsillectomy

Creating new non-influenza vaccines: an interview with Julie Phillips, CEO of BioDiem

Orexigen Therapeutics reports net loss of $16.7 million for second quarter 2012

Study suggests race-specific cutoff points for a diabetes diagnostic test

Advances in HIV/AIDS therapy and the International AIDS Conference: an interview with Professor Sharon Lewin

Scientists discover biological marker that may help identify patients’ response to antidepressants

Clinical trial targets breast cancer cells by injecting trastuzumab directly into the spinal fluid

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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