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Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?

20 Jul 2018

Novel tool predicts genes that cause disease due to production of truncated proteins

Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers, including researchers from Baylor College of Medicine, that has developed a new analytical tool to effectively and efficiently predict such candidate genes.

20 Jul 2018

Researchers identify enzyme as potential new drug target for blood disorders

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease.

20 Jul 2018

Understanding triple-negative breast cancer to develop better treatments

Breast cancer affects 1 in 8 women in her lifetime. Among the various types, triple-negative breast cancer is the rarest and most aggressive – affecting about 15 percent of breast cancer patients. It is also the least studied.

19 Jul 2018

New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions

A new machine learning framework, dubbed ExPecto, can predict the effects of genetic mutations in the so-called "dark matter" regions of the human genome.

17 Jul 2018

Researchers map family trees of cancer cells to understand how AML responds to new drug

For the first time, a team of international researchers have mapped the family trees of cancer cells in acute myeloid leukemia to understand how this blood cancer responds to a new drug, enasidenib.

17 Jul 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

Researchers seek to understand role of APOE mutation in Alzheimer's disease

If you had your genome sequenced and the report says you have the APOEε4 mutation, it does not mean you are definitely going to get Alzheimer's disease.

16 Jul 2018

Study: Negative selection plays major role in cancer evolution

Natural selection shapes genomes to evolve and to adapt but, are the rules of natural selection also applying to cancer genome evolution?

13 Jul 2018

New study identifies inherited genetic variants that raise risk of clonal hematopoiesis

A new study led by researchers at Harvard Medical School and the Harvard T.H. Chan School of Public Health has identified some of the first known inherited genetic variants that significantly raise a person's likelihood of developing clonal hematopoiesis, an age-related white blood cell condition linked with higher risk of certain blood cancers and cardiovascular disease.

12 Jul 2018

Research reveals new gears in the circadian clock

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation.

12 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Researchers develop 3D map of gene interactions that play key role in heart disease

Researchers have developed a 3D map of the gene interactions that play a key role in cardiovascular disease, a study in eLife reports.

11 Jul 2018

Scientists discover new way to predict healthy individuals at risk of developing AML

An international team of leukemia scientists has discovered how to predict healthy individuals at risk of developing acute myeloid leukemia, an aggressive and often deadly blood cancer.

10 Jul 2018

New biosensor chip detects single nucleotide polymorphism in real time with high sensitivity

A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism and send the results in real time to a smartphone, computer, or other electronic device.

10 Jul 2018

Mice study shows promise for treating genetic conditions during fetal development

Researchers at Carnegie Mellon University and Yale University have for the first time used a gene editing technique to successfully cure a genetic condition in a mouse model.

10 Jul 2018

New theory on Huntington's disease shows promise to open new avenues of drug development

McMaster University researchers have developed a new theory on Huntington's disease which is being welcomed for showing promise to open new avenues of drug development for the condition.

10 Jul 2018

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor, a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme.

10 Jul 2018

Researchers discover critical link in mapping recurrent mutations of melanoma

A critical link in mapping recurrent mutations of melanoma -- the most serious form of skin cancer in humans -- has been discovered by researchers at Washington State University School of Molecular Biosciences, in collaboration with researchers at Georgia State University.

6 Jul 2018

Bacteria adapted to the human body may become more susceptible to antibiotics

A new study published today in Nature Communications, led by scientists at the University of Liverpool in collaboration with the University of Salford, finds evidence that as bacteria adapt to the human body, they can sometimes become more susceptible to antibiotics and therefore easier to kill.

6 Jul 2018

Mutation News and Research

Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

Novel tool predicts genes that cause disease due to production of truncated proteins

Researchers identify enzyme as potential new drug target for blood disorders

Understanding triple-negative breast cancer to develop better treatments

New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions

Researchers map family trees of cancer cells to understand how AML responds to new drug

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Researchers seek to understand role of APOE mutation in Alzheimer's disease

Study: Negative selection plays major role in cancer evolution

New study identifies inherited genetic variants that raise risk of clonal hematopoiesis

Research reveals new gears in the circadian clock

Researchers elucidate role of mutations in deadly brain cancer

Researchers develop 3D map of gene interactions that play key role in heart disease

Scientists discover new way to predict healthy individuals at risk of developing AML

New biosensor chip detects single nucleotide polymorphism in real time with high sensitivity

Mice study shows promise for treating genetic conditions during fetal development

New theory on Huntington's disease shows promise to open new avenues of drug development

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

Researchers discover critical link in mapping recurrent mutations of melanoma

Bacteria adapted to the human body may become more susceptible to antibiotics

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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