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Percutaneous mitral valve repair

The scope of percutaneous cardiac therapy has expanded from percutaneous coronary and peripheral intervention to percutaneous valve intervention, first used in the mid eighties.

1 Sep 2008

Primary prevention of coronary heart disease: challenges and achievements

The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. Guidelines on this important topic have been developed and updated at regular intervals over the last 13 years, most recently in 2007.

1 Sep 2008

Fluvastatin XL use is associated with improved cardiac outcome after major vascular surgery

The DECREASE III Study which took place in the Netherlands between June 2004 and April 2008, showed that patients treated with Fluvastatin showed an improved cardiac outcome after surgery.

1 Sep 2008

Best use of drug-eluting stents: When should they be avoided?

Compared with bare metal stents, drug-eluting stents substantially reduce the risk of angiographic and clinical recurrence but do not affect mortality or the short term or long term risk of myocardial infarction.

31 Aug 2008

TIME-CHF Trial: Elderly HF patients do not benefit from intensive medical therapy

Intensified, BNP-guided therapy was no more effective than a standard, symptom-guided approach in elderly heart failure patients in reducing the number of deaths and all-cause hospitalisations. However, the response to this intervention differed significantly between patients aged 60-74 years and those aged ¡Ý75 years. This indicates the need for specific data in this large subset of very old heart failure patients who have been largely excluded from large treatment trials.

31 Aug 2008

The BEAUTIFUL study: Ivabradine and the reduction of cardiovascular events

The results of the much awaited BEAUTIFUL (morBidity-mortality EvAlUaTion of the If inhibitor ivabradine in patients with CAD and left ventricULar dysfunction) trial have shown that coronary artery disease (CAD) patients with left ventricular dysfunction (LVD) and a heart rate more than 70 bpm have a significantly higher risk of cardiovascular death and other cardiovascular events and in these patients (heart rate above 70 bpm) treatment with ivabradine further reduces the risk of the most important coronary events such as fatal and non-fatal myocardial infarction and coronary revascularisation by one third, even when these patients are already receiving optimal therapy.

31 Aug 2008

Sex differences found in response to common antidepressant

Women with depression may be much more likely than men to get relief from a commonly used, inexpensive antidepressant drug, a new national study finds. But many members of both sexes may find that it helps ease their depression symptoms.

31 Aug 2008

Cardiac ultrasound imaging goes handheld

Non-invasive imaging has revolutionized the diagnosis of the most common cardiac diseases such as valve problems and coronary heart disease. In addition, imaging techniques are developing rapidly and we anticipate that non-invasive imaging will gain further importance in the treatment of cardiac patients.

31 Aug 2008

New molecular imaging techniques aim at detection of earliest steps of disease development

An emerging discipline of noninvasive cardiac imaging, molecular imaging, has evolved constantly in the last few years and is increasingly being translated from the preclinical to the clinical level.

31 Aug 2008

Highly active antiretroviral therapy might increase risk of asthma in young children

Highly active antiretroviral therapy might increase the risk of asthma among children because of the therapy's effect on the immune system and CD4+ T cell levels, according to a study recently published in the Journal of Allergy and Clinical Immunology, Reuters reports.

29 Aug 2008

Algeta reports positive phase II data on pain palliation with Alpharadin

Algeta ASA today announced that the primary objective of its BC1-03 Phase II pain palliation study was met. The study showed that even single doses of Alpharadin in patients with painful bone metastases could produce increasing clinical benefit with increasing dose.

28 Aug 2008

Discovery of genes that may predispose to anxiety disorders

Finnish scientists have identified genes that may predispose to anxiety disorders. Research conducted under the supervision of Academy Research Fellow Iiris Hovatta have focused on genes that influence human behaviour, and some of the studied genes show a statistical association with specific anxiety disorders. The work is carried out as part of the Academy of Finland Research Programme on Neuroscience (NEURO).

27 Aug 2008

Gleevec receives FDA priority review for gastrointestinal stromal tumors after surgery

Novartis has announced that Gleevec (imatinib mesylate) tablets, (known as Glivec (imatinib) outside the US, Canada and Israel), has been granted priority review status by the US Food and Drug Administration (FDA) as the first therapy to be reviewed for use after surgery in kit-positive gastrointestinal stromal tumors (GIST).

27 Aug 2008

VioQuest Pharmaceuticals issued new U.S. patent for Lenocta

VioQuest Pharmaceuticals today announced that the United States Patent and Trademark Office has issued the first patent for the company's investigational product candidate Lenocta (sodium stibogluconate). U.S. Patent No. 7,416,723 entitled "Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases," encompasses novel compositions including Lenocta for the treatment of cancer and a broad range of other diseases.

26 Aug 2008

Role of vitamin D in kidney disease examined

Vitamin D is the key to preventing rickets and osteoporosis, but Rockefeller University scientists suspect it may also play a role in heading off atherosclerosis in people with chronic kidney disease.

26 Aug 2008

Indian physicians concerned about malaria drug resistance, recommend combination therapy

India has reported an increase in drug-resistant malaria cases this year, leading physicians to express concern and recommend that the disease be treated with a combination of drugs, India's Daily News and Analysis reports.

26 Aug 2008

HIV/AIDS groups express concern about potential for new antiretroviral advertising to 'scare off' patients

The Wall Street Journal on Monday examined a new trend for drugmakers marketing HIV/AIDS treatments to release ads that "tak[e] aim at rival HIV drugs, hinting at side effects and other drawbacks."

26 Aug 2008

Normalizing tumor vessels to improve chemotherapy drug delivery

Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Hospital Boston.

25 Aug 2008

Could a substance from the jasmine flower hold the key to an effective new therapy to treat cancer?

Prof. Eliezer Flescher of The Sackler Faculty of Medicine, Tel Aviv University thinks so. He and his colleagues have developed an anti-cancer drug based on a decade of research into the commercial applications of the compound Jasmonate, a synthetic compound derived from the flower itself.

25 Aug 2008

Breastfeeding, other factors may affect risk of breast cancer type

Factors such as age at menopause as well as a woman's breastfeeding practices can influence her risk of developing certain types of breast cancer. That was the conclusion of a new study published in the October 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer.

25 Aug 2008

Therapy News and Research

Percutaneous mitral valve repair

Primary prevention of coronary heart disease: challenges and achievements

Fluvastatin XL use is associated with improved cardiac outcome after major vascular surgery

Best use of drug-eluting stents: When should they be avoided?

TIME-CHF Trial: Elderly HF patients do not benefit from intensive medical therapy

The BEAUTIFUL study: Ivabradine and the reduction of cardiovascular events

Sex differences found in response to common antidepressant

Cardiac ultrasound imaging goes handheld

New molecular imaging techniques aim at detection of earliest steps of disease development

Highly active antiretroviral therapy might increase risk of asthma in young children

Algeta reports positive phase II data on pain palliation with Alpharadin

Discovery of genes that may predispose to anxiety disorders

Gleevec receives FDA priority review for gastrointestinal stromal tumors after surgery

VioQuest Pharmaceuticals issued new U.S. patent for Lenocta

Role of vitamin D in kidney disease examined

Indian physicians concerned about malaria drug resistance, recommend combination therapy

HIV/AIDS groups express concern about potential for new antiretroviral advertising to 'scare off' patients

Normalizing tumor vessels to improve chemotherapy drug delivery

Could a substance from the jasmine flower hold the key to an effective new therapy to treat cancer?

Breastfeeding, other factors may affect risk of breast cancer type

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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