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Cylene's Pol I inhibitor activates p53 and selectively destroys cancer cells

Cylene Pharmaceuticals today announced that research collaborators at the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne, Australia have established, for the first time, that RNA Polymerase I (Pol I) activity is essential for cancer cell survival and that its inhibition selectively activates p53 to kill tumors. Published today in Cancer Cell, the findings show that Cylene's Pol I inhibitor, CX-5461, selectively destroys cancer by activating p53 in malignant but not in normal cells.

11 Jul 2012

TLR1 plays a critical role in protecting the body from food-borne illnesses

A naturally occurring protein called TLR1 plays a critical role in protecting the body from illnesses caused by eating undercooked pork or drinking contaminated water, according to new research from the University of Southern California (USC).

11 Jul 2012

New method uses acoustic angiography to identify cancer in minutes

From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel "bendiness" can indicate the presence and progression of cancer.

11 Jul 2012

Colon cancer cells use clever trick to migrate: Study

How does a tumor cell set up a signaling pathway in order to metastasize? Scientists at Technische Universit-t M-nchen's (TUM) Klinikum rechts der Isar and Helmholtz Zentrum M-nchen have made a significant discovery in this area by studying colon cancer.

11 Jul 2012

Viewpoints: Obama's 'ideological gymnastics;' Health law's promise of mental health parity; Perry's 'platitudes' on care in Texas

Mitt Romney is under fire for flip-flopping when he declared that the individual mandate is a tax, after a campaign adviser said it was not. In a front-page story, the New York Times wrote that Romney's statement "prompted renewed criticism that he was willing to adjust his views for political expediency." Bill Burton of the pro-Obama super PAC Priorities USA opined on what he called "Romney's ideological gymnastics."

11 Jul 2012

Eosinophil count predicts mortality risk following heart procedure

Study findings suggest that eosinophil count predicts mortality risk in patients undergoing percutaneous coronary intervention.

10 Jul 2012

BP variability link to stroke risk reinforced

Analysis of data from the Women’s Health Initiative supports the contention that variability in a person’s blood pressure affects their risk for stroke.

10 Jul 2012

Lessons learned from transfusion refusal

Jehovah’s Witness patients who refuse blood transfusions during cardiac surgery are not at risk for surgical complications or long-term mortality compared with non-Witnesses who receive transfusions, report US researchers.

10 Jul 2012

Sleep loss mirrors stress affects on immune system

Acute sleep loss affects the immune system in a similar way to stress, researchers report.

10 Jul 2012

Two-drug combo increases diabetes patients’ goal achievement

Post-hoc analysis of randomized trial results shows that treating individuals with Type 2 diabetes with a combination of phentermine and topiramate increases their achievement of goals recommended for the management of their condition.

10 Jul 2012

Altered immune function in relatives of schizophrenia patients

Schizophrenia patients and their unaffected first-degree relatives exhibit immune system alterations compared with mentally healthy individuals, researchers report.

10 Jul 2012

BP variability link to stroke risk reinforced

Analysis of data from the Women’s Health Initiative supports the contention that variability in a person’s blood pressure affects their risk for stroke.

10 Jul 2012

One-quarter of ITP patients achieve 5-year treatment-free response

Approximately 25% of patients with immune thrombocytopenia purpura who receive treatment with rituximab maintain a treatment-free response lasting for at least 5 years, study findings suggest.

10 Jul 2012

Ozone concerns aired over effect on cardiac biomarkers

Exposure to ozone for as little as 2 hours could induce physiologic changes associated with cardiovascular disease, say US researchers.

10 Jul 2012

TNF-α levels linked to lithium response in BD patients

Patients with bipolar disorder who have a poor response to lithium treatment have significantly higher serum levels of tumor necrosis factor-α than those with a good response, researchers report.

10 Jul 2012

Relaxin key to improved stroke rehabilitation outcomes

Treatment with the reproductive hormone relaxin during physical rehabilitative therapy appears to improve long-term outcomes in stroke patients over rehabilitative therapy alone, say researchers.

10 Jul 2012

Shear forces cause vessel identity crisis

Lymphatic vessels exposed to fast-flowing blood take on characteristics associated with blood vessels, report researchers.

10 Jul 2012

Jehovah’s Witnesses’ beliefs do not necessarily put them at risk

Jehovah’s Witnesses do not have a significantly increased risk for complications or long-term mortality after cardiac surgery, researchers say.

10 Jul 2012

Scientists identify novel strategy to target Taspase1 enzyme

Scientists at the University Medical Center of Johannes Gutenberg University Mainz in Germany identified a novel strategy to target the oncologically relevant protein-cleaving enzyme Taspase1.

10 Jul 2012

Abbott announces CE Marking for ARCHITECT HbA1c assay

More than 346 million people worldwide are living with diabetes, and the World Diabetes Foundation estimates that number will increase by nearly 27 percent by 2030. In order to help physicians appropriately monitor treatment efficacy for these patients, Abbott announced today CE Marking (Conformite Europeenne) for the Abbott ARCHITECT HbA1c (IA) Assay.

10 Jul 2012